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Mitazalimab is a CD40 agonist antibody from Alligator Bioscience AB, in registered phase 2 trials for pancreatic ductal adenocarcinoma.
Mitazalimab is listed on ClinicalTrials.gov as an intervention in 1 registered phase 2 trial sponsored by Alligator Bioscience AB, in pancreatic ductal adenocarcinoma. It is a human CD40 agonistic IgG1 antibody, given with modified FOLFIRINOX in the OPTIMIZE-1 study (NCT04888312, Lancet Oncology 2024). OnCo records the agent from the registry alone; approvals, results and the sponsor's own description will follow as they are published.
A human IgG1 antibody that switches on CD40, the receptor on dendritic cells and macrophages that licenses them to prime T cells (OPTIMIZE-1, Lancet Oncology 2024). Despite the code ADC-1013 it is not an antibody-drug conjugate and carries no payload. Connects to CD40.
1.Mitazalimab binds CD40.
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Query for this drug: (TITLE:"Mitazalimab" OR ABSTRACT:"Mitazalimab" OR TITLE:"ADC-1013" OR ABSTRACT:"ADC-1013" OR TITLE:"JNJ-64457107" OR ABSTRACT:"JNJ-64457107") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Mitazalimab, not a curated reading list.
Shares CD40, Tumour-associated macrophages (TAMs) and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
Shares Pancreatic ductal adenocarcinoma and the tags pipeline, registry-only.
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