Relapsed and refractory acute lymphoblastic leukaemia in children · Countries and centres


Memorial Sloan Kettering Cancer Center New York · cancer center	United States	NCI comprehensive	0	5,259	96,089	Comprehensive genomic profiling CAR-T cell therapy Digital pathology & AI	#1
Charité Universitätsmedizin Berlin Berlin · university	Germany	none recorded	1	1,550	17,927	Proton therapy Proton therapy machines: cyclotrons, synchrotrons and single-room systems CyberKnife robotic radiosurgery Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)	#12
Stanford Health Care / Stanford Cancer Institute Stanford · university	United States	NCI comprehensive	0	3,114	49,877	CAR-T cell therapy SBRT / SABR (stereotactic radiotherapy)CyberKnife robotic radiosurgery Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS)+1	#30
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences Tianjin · hospital	China	none recorded	0	4,888	64,972	CAR-T cell therapy	-
Abramson Cancer Center, University of Pennsylvania Philadelphia · cancer center	United States	NCI comprehensive	0	3,093	52,239	CAR-T cell therapy In vivo CAR-T PARP PET Personalised neoantigen (mRNA) vaccines +2	-
Tongji Hospital, Huazhong University of Science and Technology Wuhan · hospital	China	none recorded	0	2,609	30,462	HPV & HBV vaccination Patient-derived organoids Immune checkpoint inhibitors CAR-T cell therapy	-
Fred Hutchinson Cancer Center Seattle · cancer center	United States	NCI comprehensive	0	2,101	28,721	CAR-T cell therapy Proton therapy Proton therapy machines: cyclotrons, synchrotrons and single-room systems	-
University College London Hospitals / UCL Cancer Institute London · hospital	United Kingdom	none recorded	0	1,946	24,827	Proton therapy CAR-T cell therapy Liquid biopsy (ctDNA)Whole-exome & whole-genome sequencing +5	-
Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine Houston, TX · cancer center	United States	NCI comprehensive	0	1,557	18,149	CAR-T cell therapy Allogeneic (off-the-shelf) cell therapy Whole-exome & whole-genome sequencing Endocrine therapy (SERMs, AIs, SERDs)	-
Peking University Cancer Hospital Beijing · cancer center	China	none recorded	0	1,521	17,126	CAR-T cell therapy Immune checkpoint inhibitors Antibody-drug conjugate (ADC)	-
Hospital Clínic de Barcelona / IDIBAPS Barcelona · hospital	Spain	none recorded	0	1,520	21,766	CAR-T cell therapy RNA sequencing & expression profiling Whole-exome & whole-genome sequencing Small-molecule kinase inhibitors	-
Department of Biotechnology, Government of India New Delhi · government	India	none recorded	0	1,354	10,641	CAR-T cell therapy HPV & HBV vaccination Point-of-care and decentralised cell manufacturing	-
Comprehensive Cancer Center Vienna, Medical University of Vienna / AKH Vienna · cancer center	Austria	none recorded	0	1,277	17,836	CDK4/6 inhibitors Carbon-ion therapy Proton therapy CAR-T cell therapy +1	-
Chinese PLA General Hospital Beijing · hospital	China	none recorded	0	1,263	11,390	CAR-T cell therapy CRISPR functional genomics Robotic & minimally invasive surgery PET/CT	-
City of Hope Duarte, CA · cancer center	United States	NCI comprehensive	0	1,220	16,232	CAR-T cell therapy Biology-guided radiotherapy (RefleXion X1, SCINTIX)	-