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The case-control study of about 15,000 people with and without cancer that GRAIL used to build and validate the Galleri blood test.
CCGA (NCT02889978) is an observational study sponsored by GRAIL, Inc. It collected blood from people newly diagnosed with cancer and from people without cancer so that GRAIL could compare sequencing approaches, train the targeted methylation classifier that became Galleri, and test its accuracy in three substudies (Liu 2020 for the second, Klein 2021 for the third, independent validation set).
The registry record, read on 29 October 2026, gives its status as unknown (the sponsor last updated it on 13 September 2023), with 15,254 participants enrolled, a start on 4 August 2016 and primary completion expected in March 2024.
Whether a cancer is found depends mostly on how much tumour DNA it sheds into the blood, which is why small early cancers are often missed by every approach.
Methylation-based screening is real but weakest exactly where pancreatic cancer needs it, at stage I, which is why high-risk surveillance rather than population screening carries the field here.
Methylation patterns can flag many cancers and point to the organ, but the cancers most worth catching early were the ones least often found.
Shares Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA, GRAIL, Galleri, Multi-cancer early detection (MCED).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
Shares GRAIL, Galleri, Multi-cancer early detection (MCED), Liquid biopsy (ctDNA).
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