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Datar Cancer Genetics' study of 30,060 people reported clumps of tumour-associated cells in the blood of about nine in ten people with cancer and about four in a hundred people without symptoms.
Gaya and colleagues harvested circulating ensembles of tumour-associated cells (C-ETACs) from 30,060 people: 9,416 with known cancer, 6,725 symptomatic with suspected cancer and 13,919 asymptomatic. C-ETACs were found in 91.8% of people with known cancer and in 92.6% of the 6,025 symptomatic people diagnosed with cancer; in a subset of 3,509, immunocytochemistry profiles matched histopathology in 93.1%. C-ETACs were undetectable in 95% of 700 symptomatic people with benign conditions and in 96.3% of the 13,919 asymptomatic individuals.
If about 3.7% of people without symptoms test positive, most positives in a screening population would not be cancer; the paper does not report how many asymptomatic positives were later diagnosed.
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