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Large drugs such as antibody-drug conjugates must cross vessel walls and travel through dense tissue. A chip with flowing channels and human tissue can measure how far they get.
Microphysiological systems with perfusable endothelial channels, stromal fibroblasts and tumour spheroids reproduce interstitial pressure, matrix density and convective transport, the variables that determine ADC, radioligand and nanoparticle penetration. Standard flat cultures and mouse models cannot measure human tissue penetration directly, and penetration is a leading cause of clinical underperformance for large modalities.
Shares Estimation of clinical trial success rates and related parameters, Payload (ADC), Lab models that fail to predict what happens in patients, Patient-derived organoids.
Shares Estimation of clinical trial success rates and related parameters, Lab models that fail to predict what happens in patients, Patient-derived organoids.
Shares Estimation of clinical trial success rates and related parameters, Lab models that fail to predict what happens in patients, Patient-derived organoids.
Shares Estimation of clinical trial success rates and related parameters, Lab models that fail to predict what happens in patients, Patient-derived organoids.
Shares Bystander effect (ADC), Payload (ADC), Antibody-drug conjugate (ADC).
Shares Estimation of clinical trial success rates and related parameters, Lab models that fail to predict what happens in patients, Patient-derived organoids.
Shares Estimation of clinical trial success rates and related parameters, Lab models that fail to predict what happens in patients, Patient-derived organoids.
Shares Estimation of clinical trial success rates and related parameters, Lab models that fail to predict what happens in patients, Patient-derived organoids.
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