{ "version": "https://jsonfeed.org/version/1.1", "title": "OnCo Edge", "home_page_url": "https://onco.cc/edge/", "feed_url": "https://onco.cc/edge/feed.json", "description": "The freshest signals in cancer: new papers, trial results, approvals and law, ranked newest first with a modest weight for approvals, phase 3 results and the leading journals.", "language": "en-GB", "authors": [ { "name": "OnCo", "url": "https://onco.cc/" } ], "items": [ { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-talazoparib-enzalutamide-metastatic-androgen-pathway-modulation-naive-or-sensitive#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-talazoparib-enzalutamide-metastatic-androgen-pathway-modulation-naive-or-sensitive", "title": "FDA approves talazoparib with enzalutamide for metastatic androgen pathway modulation-naïve or -sensitive prostate cancer with HRR gene mutations", "content_text": "On October 26, 2026, the Food and Drug Administration (FDA) approved talazoparib (Talzenna, Pfizer Inc.) in combination with enzalutamide for the treatment of adults with metastatic androgen pathway modulation-naïve or -sensitive (mAPMN/S) prostate cancer with homologous recombination repair (HRR) gene mutations, as detected by an FDA-authorized test.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-10-26", "precision": "day", "venue": "FDA", "records": [ { "id": "enzalutamide", "kind": "drug", "name": "Enzalutamide", "url": "https://onco.cc/drugs/enzalutamide/" }, { "id": "talazoparib", "kind": "drug", "name": "Talazoparib", "url": "https://onco.cc/drugs/talazoparib/" }, { "id": "prostate", "kind": "cancer", "name": "Prostate cancer", "url": "https://onco.cc/cancers/prostate/" } ] } }, { "id": 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"records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/nezglyal#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/nezglyal", "title": "Proposed new product: Nezglyal", "content_text": "EMA register: Nezglyal (leriglitazone) Authorised, 2026-09-21.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/procysbi#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/procysbi", "title": "Proposed new product: Procysbi", "content_text": "EMA register: Procysbi (mercaptamine) Authorised, 2013-09-05.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [] } }, { "id": 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"precision": "day", "venue": "EMA", "records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/waskyra#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/waskyra", "title": "Proposed new product: Waskyra", "content_text": "EMA register: Waskyra (etuvetidigene autotemcel) Authorised, 2026-01-09.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/xromi#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/xromi", "title": "Proposed new product: Xromi", "content_text": "EMA register: Xromi (hydroxycarbamide) Authorised, 2019-07-01.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/yartemlea#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/yartemlea", "title": "Proposed new product: Yartemlea", "content_text": "EMA register: Yartemlea (Narsoplimab) Opinion.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/zefylti-0#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/zefylti-0", "title": "Proposed new product: Zefylti", "content_text": "EMA register: Zefylti (filgrastim) Application withdrawn.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [] } }, { "id": "https://www.ema.europa.eu/en/medicines/human/EPAR/rasonque#onco-edge-proposal", "url": "https://www.ema.europa.eu/en/medicines/human/EPAR/rasonque", "title": "Proposed regional approval row: Daraxonrasib", "content_text": "EMA register: Rasonque (Daraxonrasib) Opinion.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "EMA", "records": [ { "id": "daraxonrasib", "kind": "drug", "name": "Daraxonrasib", "url": "https://onco.cc/drugs/daraxonrasib/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT06295432#onco-edge-proposal", "url": "https://clinicaltrials.gov/study/NCT06295432", "title": "Proposed trial status change: A Phase II Clinical Trial of DZD9008 in Combination With AZD4205 in Standard Treatment Failed NSCLC Patients With EGFR Mutations", "content_text": "ClinicalTrials.gov overall status is COMPLETED; recorded recruiting.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct06295432", "kind": "trial", "name": "A Phase II Clinical Trial of DZD9008 in Combination With AZD4205 in Standard Treatment Failed NSCLC Patients With EGFR Mutations", "url": "https://onco.cc/trials/nct06295432/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT07428044#onco-edge-proposal", "url": "https://clinicaltrials.gov/study/NCT07428044", "title": "Proposed trial status change: A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer", "content_text": "ClinicalTrials.gov overall status is WITHDRAWN; recorded recruiting.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct07428044", "kind": "trial", "name": "A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer", "url": "https://onco.cc/trials/nct07428044/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT05879822#onco-edge-proposal", "url": "https://clinicaltrials.gov/study/NCT05879822", "title": "Proposed trial status change: A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive", "content_text": "ClinicalTrials.gov overall status is TERMINATED; recorded active.", "date_published": "2026-10-31T00:00:00Z", "tags": [ "proposal" ], "_onco": { "kind": "proposal", "date": "2026-10-31", "precision": "day", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct05879822", "kind": "trial", "name": "A Study to Evaluate INCB099280 in Participants With Select Solid Tumors Who Are Immune Checkpoint Inhibitor Naive", "url": "https://onco.cc/trials/nct05879822/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.1278#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.1278", "title": "Adjuvant chemotherapy with cisplatin and gemcitabine compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1/AIO-HEP-0112 trial).", "content_text": "Published in Ann Oncol on 24 October 2026; found by the roadmap watch for ACTICCA-1.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.1278", "records": [ { "id": "acticca-1", "kind": "trial", "name": "ACTICCA-1", "url": "https://onco.cc/trials/acticca-1/" }, { "id": "gallbladder-cancer-roadmap", "kind": "roadmap", "name": "Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials", "url": "https://onco.cc/roadmaps/gallbladder-cancer-roadmap/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.1282#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.1282", "title": "Atirmociclib and fulvestrant for patients with HR+/HER2- advanced/metastatic breast cancer who progressed on a prior cyclin-dependent kinase 4/6 inhibitor: primary analysis of the randomized FourLight-1 trial.", "content_text": "Published in Ann Oncol on 24 October 2026; found by the roadmap watch for FOURLIGHT-1.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.1282", "records": [ { "id": "fourlight-1", "kind": "trial", "name": "FOURLIGHT-1", "url": "https://onco.cc/trials/fourlight-1/" }, { "id": "hormonal-therapy-roadmap", "kind": "roadmap", "name": "Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test", "url": "https://onco.cc/roadmaps/hormonal-therapy-roadmap/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.09.009#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.09.009", "title": "Final results of nivolumab plus ipilimumab versus nivolumab or chemotherapy in microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer from CheckMate 8HW.", "content_text": "Published in Ann Oncol on 24 October 2026; found by the roadmap watch for CheckMate 8HW.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.09.009", "records": [ { "id": "checkmate-8hw", "kind": "trial", "name": "CheckMate 8HW", "url": "https://onco.cc/trials/checkmate-8hw/" }, { "id": "colorectal-roadmap", "kind": "roadmap", "name": "Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation", "url": "https://onco.cc/roadmaps/colorectal-roadmap/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.1283#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.1283", "title": "Overall survival from the phase III postMONARCH trial of abemaciclib plus fulvestrant versus placebo plus fulvestrant for HR+, HER2- advanced breast cancer following progression on a prior CDK4/6 inhibitor plus endocrine therapy.", "content_text": "Published in Ann Oncol on 24 October 2026; found by the roadmap watch for postMONARCH.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.1283", "records": [ { "id": "postmonarch", "kind": "trial", "name": "postMONARCH", "url": "https://onco.cc/trials/postmonarch/" }, { "id": "hormonal-therapy-roadmap", "kind": "roadmap", "name": "Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test", "url": "https://onco.cc/roadmaps/hormonal-therapy-roadmap/" } ] } }, { "id": "https://onco.cc/newsletter/2026-10-30/#onco-edge-issue", "url": "https://onco.cc/newsletter/2026-10-30/", "title": "OnCo weekly, 2026-10-30", "content_text": "1105 changelog entries, 5 corrections.", "date_published": "2026-10-30T00:00:00Z", "tags": [ "issue" ], "_onco": { "kind": "issue", "date": "2026-10-30", "precision": "day", "venue": "OnCo weekly issue", "records": [] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.1290#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.1290", "title": "Active surveillance versus standard surgery after neoadjuvant chemoradiotherapy for oesophageal cancer: long-term results of a cluster-randomised controlled trial (SANO).", "content_text": "Published in Ann Oncol on 23 October 2026; found by the roadmap watch for SANO.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.1290", "records": [ { "id": "sano", "kind": "trial", "name": "SANO", "url": "https://onco.cc/trials/sano/" }, { "id": "surgery-roadmap", "kind": "roadmap", "name": "Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work", "url": "https://onco.cc/roadmaps/surgery-roadmap/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.097#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.097", "title": "Capivasertib plus abiraterone in PTEN-deficient de novo metastatic hormone-sensitive prostate cancer: updated survival analysis from CAPItello-281.", "content_text": "Published in Ann Oncol on 23 October 2026; found by the roadmap watch for CAPItello-281.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.097", "records": [ { "id": "capitello-281", "kind": "trial", "name": "CAPItello-281", "url": "https://onco.cc/trials/capitello-281/" }, { "id": "hormonal-therapy-roadmap", "kind": "roadmap", "name": "Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test", "url": "https://onco.cc/roadmaps/hormonal-therapy-roadmap/" }, { "id": "prostate-roadmap", "kind": "roadmap", "name": "Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch", "url": "https://onco.cc/roadmaps/prostate-roadmap/" } ] } }, { "id": "https://doi.org/10.1038/s41591-026-04734-7#onco-edge-paper", "url": "https://doi.org/10.1038/s41591-026-04734-7", "title": "Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic cancer: the randomized phase 2 AMPLIFY-7P trial.", "content_text": "Published in Nat Med on 23 October 2026; found by the roadmap watch for AMPLIFY-7P.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "venue": "Nat Med", "doi": "10.1038/s41591-026-04734-7", "records": [ { "id": "amplify-7p", "kind": "trial", "name": "AMPLIFY-7P", "url": "https://onco.cc/trials/amplify-7p/" }, { "id": "pancreatic-roadmap", "kind": "roadmap", "name": "Pancreatic cancer roadmap: from Whipple's operation to gemcitabine, FOLFIRINOX, adjuvant chemotherapy, PARP inhibition, KRAS inhibition, vaccines and the surveillance question", "url": "https://onco.cc/roadmaps/pancreatic-roadmap/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.1288#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.1288", "title": "Overall survival with adjuvant ribociclib plus nonsteroidal aromatase inhibitor in patients with high-risk HR+/HER2- early breast cancer: Six-year follow-up of the NATALEE trial.", "content_text": "Published in Ann Oncol on 23 October 2026; found by the roadmap watch for NATALEE.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.1288", "records": [ { "id": "natalee", "kind": "trial", "name": "NATALEE", "url": "https://onco.cc/trials/natalee/" }, { "id": "hormonal-therapy-roadmap", "kind": "roadmap", "name": "Hormonal therapy roadmap: removing the ovaries → tamoxifen → oral degraders switched by a blood test", "url": "https://onco.cc/roadmaps/hormonal-therapy-roadmap/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-traditional-approval-pembrolizumab-or-pembrolizumab-and-berahyaluronidase-alfa-pmph#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-traditional-approval-pembrolizumab-or-pembrolizumab-and-berahyaluronidase-alfa-pmph", "title": "FDA grants traditional approval for pembrolizumab or pembrolizumab and berahyaluronidase alfa-pmph for unresectable or metastatic TMB-H solid tumors with updated indication", "content_text": "On October 16, 2026, the Food and Drug Administration granted traditional approval to pembrolizumab (Keytruda, Merck) or pembrolizumab and berahyaluronidase alfa-pmph (Keytruda Qlex, Merck) for adult and pediatric patients with unresectable or metastatic tumor mutational burden-high (TMB-H) [≥13 mutations/megabase (mut/Mb)] solid tumors, as determined by an FDA-authorized test, that have progressed following prior treatment and who have no satisfactory alternative treatment options.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-10-16", "precision": "day", "venue": "FDA", "records": [ { "id": "pembrolizumab", "kind": "drug", "name": "Pembrolizumab", "url": "https://onco.cc/drugs/pembrolizumab/" } ] } }, { "id": "https://onco.cc/newsletter/2026-10-29/#onco-edge-issue", "url": "https://onco.cc/newsletter/2026-10-29/", "title": "OnCo weekly, 2026-10-29", "content_text": "1100 changelog entries, 5 corrections.", "date_published": "2026-10-29T00:00:00Z", "tags": [ "issue" ], "_onco": { "kind": "issue", "date": "2026-10-29", "precision": "day", "venue": "OnCo weekly issue", "records": [] } }, { "id": "https://doi.org/10.1515/cclm-2026-0822#onco-edge-paper", "url": "https://doi.org/10.1515/cclm-2026-0822", "title": "Deep phenotyping of blood cell data reveals novel clinical biomarkers.", "content_text": "Published on 28 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.", "date_published": "2026-10-28T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-28", "precision": "day", "doi": "10.1515/cclm-2026-0822", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.1016/s0140-6736(26)01602-8#onco-edge-paper", "url": "https://doi.org/10.1016/s0140-6736(26)01602-8", "title": "Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial.", "content_text": "Published in Lancet on 21 October 2026; found by the roadmap watch for NICHE-2.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "venue": "Lancet", "doi": "10.1016/s0140-6736(26)01602-8", "records": [ { "id": "niche-2", "kind": "trial", "name": "NICHE-2", "url": "https://onco.cc/trials/niche-2/" }, { "id": "colorectal-roadmap", "kind": "roadmap", "name": "Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation", "url": "https://onco.cc/roadmaps/colorectal-roadmap/" }, { "id": "surgery-roadmap", "kind": "roadmap", "name": "Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work", "url": "https://onco.cc/roadmaps/surgery-roadmap/" }, { "id": "trial-modernisation-roadmap", "kind": "roadmap", "name": "Trial modernisation roadmap: the randomised trial → platforms and adaptive designs → decentralised, pragmatic and always-on", "url": "https://onco.cc/roadmaps/trial-modernisation-roadmap/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-expanded-indication-nogapendekin-alfa-inbakicept-pmln-bcg-unresponsive-non-muscle#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-expanded-indication-nogapendekin-alfa-inbakicept-pmln-bcg-unresponsive-non-muscle", "title": "FDA approves an expanded indication for nogapendekin alfa inbakicept-pmln for BCG-unresponsive non-muscle invasive bladder cancer", "content_text": "On October 14, 2026, the Food and Drug Administration (FDA) approved nogapendekin alfa inbakicept-pmln (Anktiva, Altor BioScience, LLC, an indirect wholly-owned subsidiary of ImmunityBio, Inc.) with Bacillus Calmette-Guérin (BCG) for adults with BCG-unresponsive non-muscle invasive bladder cancer (NMIBC).", "date_published": "2026-10-14T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-10-14", "precision": "day", "venue": "FDA", "records": [ { "id": "nogapendekin-alfa", "kind": "drug", "name": "Nogapendekin alfa inbakicept", "url": "https://onco.cc/drugs/nogapendekin-alfa/" }, { "id": "urothelial", "kind": "cancer", "name": "Bladder & urothelial cancer", "url": "https://onco.cc/cancers/urothelial/" }, { "id": "non-muscle-invasive-bladder-cancer", "kind": "cancer", "name": "Non-muscle-invasive bladder cancer", "url": "https://onco.cc/cancers/non-muscle-invasive-bladder-cancer/" } ] } }, { "id": "https://onco.cc/newsletter/2026-10-27/#onco-edge-issue", "url": "https://onco.cc/newsletter/2026-10-27/", "title": "OnCo weekly, 2026-10-27", "content_text": "1068 changelog entries, 3 corrections.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "issue" ], "_onco": { "kind": "issue", "date": "2026-10-27", "precision": "day", "venue": "OnCo weekly issue", "records": [] } }, { "id": "https://doi.org/10.1038/s44386-026-00092-z#onco-edge-paper", "url": "https://doi.org/10.1038/s44386-026-00092-z", "title": "Activity-based proteomics discovery of deubiquitinating enzyme inhibitors with immunomodulatory activity.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1038/s44386-026-00092-z", "records": [ { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" } ] } }, { "id": "https://doi.org/10.1084/jem.20261199#onco-edge-paper", "url": "https://doi.org/10.1084/jem.20261199", "title": "Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched MET, State and CIITA.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1084/jem.20261199", "records": [ { "id": "met", "kind": "target", "name": "MET", "url": "https://onco.cc/targets/met/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "ciita", "kind": "target", "name": "CIITA", "url": "https://onco.cc/targets/ciita/" }, { "id": "cd4", "kind": "target", "name": "CD4", "url": "https://onco.cc/targets/cd4/" } ] } }, { "id": "https://doi.org/10.1186/s40164-026-00831-y#onco-edge-paper", "url": "https://doi.org/10.1186/s40164-026-00831-y", "title": "Comparative characterization of OncoPro™ and Wnt-based media reveals distinct phenotypic and pharmacologic states in patient-derived tumor organoids.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched Whole-exome & whole-genome sequencing, RNA sequencing & expression profiling and Single-cell & spatial profiling.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1186/s40164-026-00831-y", "records": [ { "id": "wes-wgs", "kind": "technology", "name": "Whole-exome & whole-genome sequencing", "url": "https://onco.cc/technologies/wes-wgs/" }, { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "lgr5-gene", "kind": "target", "name": "LGR5", "url": "https://onco.cc/targets/lgr5-gene/" } ] } }, { "id": "https://doi.org/10.1038/s44386-026-00081-2#onco-edge-paper", "url": "https://doi.org/10.1038/s44386-026-00081-2", "title": "Design of Tissue-Selective PROTACs Through Recruiting E3 Ligase Scaffolding Protein MAGEA11.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched PROTACs & molecular glues, Proteasome and Cereblon.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1038/s44386-026-00081-2", "records": [ { "id": "protac-degrader", "kind": "technology", "name": "PROTACs & molecular glues", "url": "https://onco.cc/technologies/protac-degrader/" }, { "id": "proteasome", "kind": "target", "name": "Proteasome", "url": "https://onco.cc/targets/proteasome/" }, { "id": "cereblon", "kind": "target", "name": "Cereblon", "url": "https://onco.cc/targets/cereblon/" }, { "id": "brd4", "kind": "target", "name": "BRD4", "url": "https://onco.cc/targets/brd4/" }, { "id": "vhl", "kind": "target", "name": "VHL", "url": "https://onco.cc/targets/vhl/" }, { "id": "max", "kind": "target", "name": "MAX", "url": "https://onco.cc/targets/max/" } ] } }, { "id": "https://doi.org/10.1016/j.celrep.2026.118209#onco-edge-paper", "url": "https://doi.org/10.1016/j.celrep.2026.118209", "title": "E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cycles.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched ATR, ATM and CIP2A.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1016/j.celrep.2026.118209", "records": [ { "id": "atr", "kind": "target", "name": "ATR", "url": "https://onco.cc/targets/atr/" }, { "id": "atm", "kind": "target", "name": "ATM", "url": "https://onco.cc/targets/atm/" }, { "id": "cip2a", "kind": "target", "name": "CIP2A", "url": "https://onco.cc/targets/cip2a/" }, { "id": "sirt1", "kind": "target", "name": "SIRT1", "url": "https://onco.cc/targets/sirt1/" } ] } }, { "id": "https://doi.org/10.58347/tml.2026.1766e#onco-edge-paper", "url": "https://doi.org/10.58347/tml.2026.1766e", "title": "Iberdomide (Zenbexus) for multiple myeloma.", "content_text": "Published in Med Lett Drugs Ther on 26 October 2026; matched the OnCo record for Iberdomide.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "venue": "Med Lett Drugs Ther", "doi": "10.58347/tml.2026.1766e", "records": [ { "id": "iberdomide", "kind": "drug", "name": "Iberdomide", "url": "https://onco.cc/drugs/iberdomide/" } ] } }, { "id": "https://doi.org/10.7554/elife.108646#onco-edge-paper", "url": "https://doi.org/10.7554/elife.108646", "title": "Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, Spatial transcriptomics and BTG2.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.7554/elife.108646", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "spatial-transcriptomics", "kind": "technology", "name": "Spatial transcriptomics", "url": "https://onco.cc/technologies/spatial-transcriptomics/" }, { "id": "btg2", "kind": "target", "name": "BTG2", "url": "https://onco.cc/targets/btg2/" } ] } }, { "id": "https://doi.org/10.1371/journal.pone.0359273#onco-edge-paper", "url": "https://doi.org/10.1371/journal.pone.0359273", "title": "Navigating HPV vaccination challenges in low-resource settings: Practical strategies for estimating the size of out-of-school girls.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched HPV & HBV vaccination.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1371/journal.pone.0359273", "records": [ { "id": "hpv-vaccine", "kind": "technology", "name": "HPV & HBV vaccination", "url": "https://onco.cc/technologies/hpv-vaccine/" } ] } }, { "id": "https://onco.cc/newsletter/2026-10-26/#onco-edge-issue", "url": "https://onco.cc/newsletter/2026-10-26/", "title": "OnCo weekly, 2026-10-26", "content_text": "1065 changelog entries, 3 corrections.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "issue" ], "_onco": { "kind": "issue", "date": "2026-10-26", "precision": "day", "venue": "OnCo weekly issue", "records": [] } }, { "id": "https://doi.org/10.1016/j.celrep.2026.118201#onco-edge-paper", "url": "https://doi.org/10.1016/j.celrep.2026.118201", "title": "RAStoERK: A reference interaction atlas for insights into signaling and disease.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched Atlas and ARAF.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1016/j.celrep.2026.118201", "records": [ { "id": "atlas-aignostics", "kind": "technology", "name": "Atlas", "url": "https://onco.cc/technologies/atlas-aignostics/" }, { "id": "araf", "kind": "target", "name": "ARAF", "url": "https://onco.cc/targets/araf/" } ] } }, { "id": "https://doi.org/10.1091/mbc.e26-01-0053#onco-edge-paper", "url": "https://doi.org/10.1091/mbc.e26-01-0053", "title": "Reversibility of nuclear and 3D genomic changes in non-cancerous fibroblasts after constricted migration.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched State.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1091/mbc.e26-01-0053", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.7554/elife.109956#onco-edge-paper", "url": "https://doi.org/10.7554/elife.109956", "title": "SARS-CoV-2 main protease inhibition through dimerization promotion by peptidomimetic inhibitors and disruption by ebselen.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched State.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.7554/elife.109956", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.1016/j.molcel.2026.10.005#onco-edge-paper", "url": "https://doi.org/10.1016/j.molcel.2026.10.005", "title": "The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched CRISPR functional genomics, ATR and BRCA1 / BRCA2.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1016/j.molcel.2026.10.005", "records": [ { "id": "crispr-screens", "kind": "technology", "name": "CRISPR functional genomics", "url": "https://onco.cc/technologies/crispr-screens/" }, { "id": "atr", "kind": "target", "name": "ATR", "url": "https://onco.cc/targets/atr/" }, { "id": "brca", "kind": "target", "name": "BRCA1 / BRCA2", "url": "https://onco.cc/targets/brca/" }, { "id": "ercc4", "kind": "target", "name": "ERCC4", "url": "https://onco.cc/targets/ercc4/" }, { "id": "exo1", "kind": "target", "name": "EXO1", "url": "https://onco.cc/targets/exo1/" } ] } }, { "id": "https://doi.org/10.7554/elife.110038#onco-edge-paper", "url": "https://doi.org/10.7554/elife.110038", "title": "The transcription factor BCL11A restores differentiation potential to aged oligodendrocyte progenitor cells.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched BCL11A.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.7554/elife.110038", "records": [ { "id": "bcl11a", "kind": "target", "name": "BCL11A", "url": "https://onco.cc/targets/bcl11a/" } ] } }, { "id": "https://doi.org/10.1093/gbe/evag271#onco-edge-paper", "url": "https://doi.org/10.1093/gbe/evag271", "title": "The yEvo Mutation Browser: Enhancing student understanding of experimental evolution and genomics through interactive data visualization.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched Whole-exome & whole-genome sequencing.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1093/gbe/evag271", "records": [ { "id": "wes-wgs", "kind": "technology", "name": "Whole-exome & whole-genome sequencing", "url": "https://onco.cc/technologies/wes-wgs/" } ] } }, { "id": "https://doi.org/10.1093/narcan/zcag031#onco-edge-paper", "url": "https://doi.org/10.1093/narcan/zcag031", "title": "xNNPCD identifies regulators of programmed cell death by integrating perturbation transcriptomes with cancer dependency profiles.", "content_text": "Published on 26 October 2026 after first appearing as a preprint; matched Decitabine, SLC6A2 and HSPA5.", "date_published": "2026-10-26T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-26", "precision": "day", "doi": "10.1093/narcan/zcag031", "records": [ { "id": "decitabine", "kind": "drug", "name": "Decitabine", "url": "https://onco.cc/drugs/decitabine/" }, { "id": "slc6a2", "kind": "target", "name": "SLC6A2", "url": "https://onco.cc/targets/slc6a2/" }, { "id": "hspa5", "kind": "target", "name": "HSPA5", "url": "https://onco.cc/targets/hspa5/" } ] } }, { "id": "https://doi.org/10.1007/s12104-026-10282-5#onco-edge-paper", "url": "https://doi.org/10.1007/s12104-026-10282-5", "title": "Chemical shift assignments of the dimerization domain of NF-KappaB c-Rel subunit.", "content_text": "Published on 25 October 2026 after first appearing as a preprint; matched REL, RELA and CD40.", "date_published": "2026-10-25T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-25", "precision": "day", "doi": "10.1007/s12104-026-10282-5", "records": [ { "id": "rel", "kind": "target", "name": "REL", "url": "https://onco.cc/targets/rel/" }, { "id": "rela", "kind": "target", "name": "RELA", "url": "https://onco.cc/targets/rela/" }, { "id": "cd40", "kind": "target", "name": "CD40", "url": "https://onco.cc/targets/cd40/" } ] } }, { "id": "https://doi.org/10.1002/mc.70176#onco-edge-paper", "url": "https://doi.org/10.1002/mc.70176", "title": "Fusion Detection in Microsecretory Adenocarcinoma and Mucoepidermoid Carcinoma Using Chromogenic RNA In Situ Hybridization: A Promising Alternative to DNA-Based Fluorescence In-Situ Hybridization.", "content_text": "Published on 25 October 2026 after first appearing as a preprint; matched MEF2C, MAML2 and CRTC1.", "date_published": "2026-10-25T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-25", "precision": "day", "doi": "10.1002/mc.70176", "records": [ { "id": "mef2c", "kind": "target", "name": "MEF2C", "url": "https://onco.cc/targets/mef2c/" }, { "id": "maml2", "kind": "target", "name": "MAML2", "url": "https://onco.cc/targets/maml2/" }, { "id": "crtc1", "kind": "target", "name": "CRTC1", "url": "https://onco.cc/targets/crtc1/" }, { "id": "ss18", "kind": "target", "name": "SS18", "url": "https://onco.cc/targets/ss18/" } ] } }, { "id": "https://doi.org/10.1186/s43556-026-00643-w#onco-edge-paper", "url": "https://doi.org/10.1186/s43556-026-00643-w", "title": "EZH2 coordinates inflammatory and pain-associated pathways across joint compartments in osteoarthritis.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics, Epigenetic drugs and EZH2.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1186/s43556-026-00643-w", "records": [ { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" }, { "id": "epigenetic-drugs", "kind": "technology", "name": "Epigenetic drugs", "url": "https://onco.cc/technologies/epigenetic-drugs/" }, { "id": "ezh2", "kind": "target", "name": "EZH2", "url": "https://onco.cc/targets/ezh2/" }, { "id": "kheiron-mia", "kind": "drug", "name": "Mia", "url": "https://onco.cc/drugs/kheiron-mia/" }, { "id": "pax6", "kind": "target", "name": "PAX6", "url": "https://onco.cc/targets/pax6/" } ] } }, { "id": "https://doi.org/10.1007/s12308-026-00744-z#onco-edge-paper", "url": "https://doi.org/10.1007/s12308-026-00744-z", "title": "HHV8-associated multicentric Castleman disease with Kaposi sarcoma in an immunocompetent patient: a case report and review of the literature.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched KMT2A (MLL) rearrangement, Rituximab and Doxorubicin.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1007/s12308-026-00744-z", "records": [ { "id": "kmt2a", "kind": "target", "name": "KMT2A (MLL) rearrangement", "url": "https://onco.cc/targets/kmt2a/" }, { "id": "rituximab", "kind": "drug", "name": "Rituximab", "url": "https://onco.cc/drugs/rituximab/" }, { "id": "doxorubicin", "kind": "drug", "name": "Doxorubicin", "url": "https://onco.cc/drugs/doxorubicin/" }, { "id": "eml4", "kind": "target", "name": "EML4", "url": "https://onco.cc/targets/eml4/" }, { "id": "atrx", "kind": "target", "name": "ATRX", "url": "https://onco.cc/targets/atrx/" }, { "id": "klf4", "kind": "target", "name": "KLF4", "url": "https://onco.cc/targets/klf4/" } ] } }, { "id": "https://doi.org/10.1007/s00423-026-04340-8#onco-edge-paper", "url": "https://doi.org/10.1007/s00423-026-04340-8", "title": "High prevalence of TROP2 expression identifies EBV-positive gastric cancer as a candidate for TROP2-directed antibody-drug conjugates.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched Histopathology & immunohistochemistry, Antibody-drug conjugate and Immune checkpoint inhibitors.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1007/s00423-026-04340-8", "records": [ { "id": "histopathology-ihc", "kind": "technology", "name": "Histopathology & immunohistochemistry", "url": "https://onco.cc/technologies/histopathology-ihc/" }, { "id": "adc", "kind": "technology", "name": "Antibody-drug conjugate", "url": "https://onco.cc/technologies/adc/" }, { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" }, { "id": "trop2", "kind": "target", "name": "TROP2", "url": "https://onco.cc/targets/trop2/" } ] } }, { "id": "https://doi.org/10.1093/cvr/cvag246#onco-edge-paper", "url": "https://doi.org/10.1093/cvr/cvag246", "title": "Human T cells from resistant hypertension patients promote hypertension via tnf in humanized mice.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched CLTC and CD4.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1093/cvr/cvag246", "records": [ { "id": "cltc", "kind": "target", "name": "CLTC", "url": "https://onco.cc/targets/cltc/" }, { "id": "cd4", "kind": "target", "name": "CD4", "url": "https://onco.cc/targets/cd4/" } ] } }, { "id": "https://doi.org/10.1007/s12017-026-08952-7#onco-edge-paper", "url": "https://doi.org/10.1007/s12017-026-08952-7", "title": "Interferon Regulatory Factor 8 Drives Autoimmune Neuroinflammation in Experimental Autoimmune Encephalomyelitis.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched IRF8.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1007/s12017-026-08952-7", "records": [ { "id": "irf8", "kind": "target", "name": "IRF8", "url": "https://onco.cc/targets/irf8/" } ] } }, { "id": "https://doi.org/10.1007/s10198-026-01969-6#onco-edge-paper", "url": "https://doi.org/10.1007/s10198-026-01969-6", "title": "Modelling the potential contributions of polygenic risk stratification to cost-effective screening for prostate cancer.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched KLK3.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1007/s10198-026-01969-6", "records": [ { "id": "klk3", "kind": "target", "name": "KLK3", "url": "https://onco.cc/targets/klk3/" } ] } }, { "id": "https://doi.org/10.1186/s42155-026-00792-7#onco-edge-paper", "url": "https://doi.org/10.1186/s42155-026-00792-7", "title": "Post-embolization dynamic changes in Obsidio Conformable Embolic: volume and radiodensity analysis.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched CT.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1186/s42155-026-00792-7", "records": [ { "id": "ct", "kind": "technology", "name": "CT", "url": "https://onco.cc/technologies/ct/" } ] } }, { "id": "https://doi.org/10.1007/s11064-026-04905-5#onco-edge-paper", "url": "https://doi.org/10.1007/s11064-026-04905-5", "title": "SLC16A13 Promotes Malignant Progression in Glioma via Metabolic Reprogramming and Disruption of Monocarboxylate Homeostasis.", "content_text": "Published on 24 October 2026 after first appearing as a preprint; matched Pertuzumab, Atlas and Ki-67.", "date_published": "2026-10-24T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-24", "precision": "day", "doi": "10.1007/s11064-026-04905-5", "records": [ { "id": "pertuzumab", "kind": "drug", "name": "Pertuzumab", "url": "https://onco.cc/drugs/pertuzumab/" }, { "id": "atlas-aignostics", "kind": "technology", "name": "Atlas", "url": "https://onco.cc/technologies/atlas-aignostics/" }, { "id": "mki67", "kind": "target", "name": "Ki-67", "url": "https://onco.cc/targets/mki67/" }, { "id": "tert", "kind": "target", "name": "TERT", "url": "https://onco.cc/targets/tert/" } ] } }, { "id": "https://doi.org/10.1186/s13052-026-02299-2#onco-edge-paper", "url": "https://doi.org/10.1186/s13052-026-02299-2", "title": "Can mesenchymal stem cell and retinoic acid therapies more effectively reduce lung damage due to bronchopulmonary dysplasia?", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched Mesenchymal stromal cells for tissue damage.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1186/s13052-026-02299-2", "records": [ { "id": "rejuv-frontier-mesenchymal-stromal-cells", "kind": "technology", "name": "Mesenchymal stromal cells for tissue damage", "url": "https://onco.cc/technologies/rejuv-frontier-mesenchymal-stromal-cells/" } ] } }, { "id": "https://doi.org/10.1016/j.cell.2026.09.045#onco-edge-paper", "url": "https://doi.org/10.1016/j.cell.2026.09.045", "title": "Cell-state-specific metabolic networks govern ferroptosis versus apoptosis in small cell lung cancer.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched State and ASCL1.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1016/j.cell.2026.09.045", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "ascl1", "kind": "target", "name": "ASCL1", "url": "https://onco.cc/targets/ascl1/" } ] } }, { "id": "https://doi.org/10.1038/s44318-026-00931-9#onco-edge-paper", "url": "https://doi.org/10.1038/s44318-026-00931-9", "title": "Differential roles for the spindle assembly checkpoint in error surveillance and mitotic timing.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched Synthetic lethality approaches, APC and MXI1.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1038/s44318-026-00931-9", "records": [ { "id": "synthetic-lethality-approaches", "kind": "technology", "name": "Synthetic lethality approaches", "url": "https://onco.cc/technologies/synthetic-lethality-approaches/" }, { "id": "apc", "kind": "target", "name": "APC", "url": "https://onco.cc/targets/apc/" }, { "id": "mxi1", "kind": "target", "name": "MXI1", "url": "https://onco.cc/targets/mxi1/" } ] } }, { "id": "https://doi.org/10.1093/nar/gkag1031#onco-edge-paper", "url": "https://doi.org/10.1093/nar/gkag1031", "title": "FITdb, an integrated Functional Immunogenomics and Transcriptomics database.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1093/nar/gkag1031", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.1093/bioinformatics/btag790#onco-edge-paper", "url": "https://doi.org/10.1093/bioinformatics/btag790", "title": "LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1093/bioinformatics/btag790", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" } ] } }, { "id": "https://doi.org/10.1083/jcb.202604150#onco-edge-paper", "url": "https://doi.org/10.1083/jcb.202604150", "title": "Midzone bundles of the mammalian anaphase spindle are mechanically coupled both locally and globally.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched PRC1.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1083/jcb.202604150", "records": [ { "id": "prc1", "kind": "target", "name": "PRC1", "url": "https://onco.cc/targets/prc1/" } ] } }, { "id": "https://doi.org/10.1016/j.molcel.2026.09.040#onco-edge-paper", "url": "https://doi.org/10.1016/j.molcel.2026.09.040", "title": "PARP1 directly disassembles nucleosomes to regulate DNA repair.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched PARP.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1016/j.molcel.2026.09.040", "records": [ { "id": "parp", "kind": "target", "name": "PARP", "url": "https://onco.cc/targets/parp/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aee5241#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aee5241", "title": "RAF isoform selectivity of MEK inhibitors and rational design of a covalent ARAF-MEK inhibitor.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched CRAF, Trametinib and ARAF.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1126/sciadv.aee5241", "records": [ { "id": "raf1", "kind": "target", "name": "CRAF", "url": "https://onco.cc/targets/raf1/" }, { "id": "trametinib", "kind": "drug", "name": "Trametinib", "url": "https://onco.cc/drugs/trametinib/" }, { "id": "araf", "kind": "target", "name": "ARAF", "url": "https://onco.cc/targets/araf/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aeg5791#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aeg5791", "title": "Retroviral insertions contributed to the divergence of human and chimpanzee brains.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched DNA methylation profiling.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1126/sciadv.aeg5791", "records": [ { "id": "methylation-profiling", "kind": "technology", "name": "DNA methylation profiling", "url": "https://onco.cc/technologies/methylation-profiling/" } ] } }, { "id": "https://doi.org/10.1038/s41375-026-03176-x#onco-edge-paper", "url": "https://doi.org/10.1038/s41375-026-03176-x", "title": "Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched Venetoclax and MECOM.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1038/s41375-026-03176-x", "records": [ { "id": "venetoclax", "kind": "drug", "name": "Venetoclax", "url": "https://onco.cc/drugs/venetoclax/" }, { "id": "mecom", "kind": "target", "name": "MECOM", "url": "https://onco.cc/targets/mecom/" } ] } }, { "id": "https://doi.org/10.1007/s11701-026-04088-9#onco-edge-paper", "url": "https://doi.org/10.1007/s11701-026-04088-9", "title": "Short-term outcomes of mini-thoracotomy, multiportal video-assisted thoracic surgery, and multiportal robot-assisted thoracic surgery for complex segmentectomy.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched Azacitidine and Decitabine + cedazuridine.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1007/s11701-026-04088-9", "records": [ { "id": "azacitidine", "kind": "drug", "name": "Azacitidine", "url": "https://onco.cc/drugs/azacitidine/" }, { "id": "decitabine-cedazuridine", "kind": "drug", "name": "Decitabine + cedazuridine", "url": "https://onco.cc/drugs/decitabine-cedazuridine/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aeg5840#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aeg5840", "title": "Structural basis for start codon selection by eIF5-mimic proteins.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched MYC.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1126/sciadv.aeg5840", "records": [ { "id": "myc-gene", "kind": "target", "name": "MYC", "url": "https://onco.cc/targets/myc-gene/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aee5701#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aee5701", "title": "TET2-driven activation of AGO2 links epigenetic remodeling to myeloid commitment and leukemia.", "content_text": "Published on 23 October 2026 after first appearing as a preprint; matched DNA methylation profiling and TET2.", "date_published": "2026-10-23T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-23", "precision": "day", "doi": "10.1126/sciadv.aee5701", "records": [ { "id": "methylation-profiling", "kind": "technology", "name": "DNA methylation profiling", "url": "https://onco.cc/technologies/methylation-profiling/" }, { "id": "tet2", "kind": "target", "name": "TET2", "url": "https://onco.cc/targets/tet2/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.102#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.102", "title": "Efficacy and safety of camrelizumab plus docetaxel and carboplatin as neoadjuvant therapy for stage II-III triple-negative breast cancer: the HELEN-Trio 011 randomized clinical trial.", "content_text": "Published in Ann Oncol on 16 October 2026; matched the OnCo record for Camrelizumab.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.102", "records": [ { "id": "camrelizumab", "kind": "drug", "name": "Camrelizumab", "url": "https://onco.cc/drugs/camrelizumab/" } ] } }, { "id": "https://doi.org/10.1182/blood.2026033409#onco-edge-paper", "url": "https://doi.org/10.1182/blood.2026033409", "title": "Genomic and clinical landscape of RAS mutations in acute myeloid leukemia.", "content_text": "Published in Blood on 16 October 2026; matched the OnCo record for CBL.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Blood", "doi": "10.1182/blood.2026033409", "records": [ { "id": "cbl", "kind": "target", "name": "CBL", "url": "https://onco.cc/targets/cbl/" }, { "id": "gna13", "kind": "target", "name": "GNA13", "url": "https://onco.cc/targets/gna13/" } ] } }, { "id": "https://doi.org/10.1007/s00520-026-11377-4#onco-edge-paper", "url": "https://doi.org/10.1007/s00520-026-11377-4", "title": "Evaluating disparities in counseling and resources for chemotherapy-induced hair loss: qualitative analysis of a survey-based approach.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched Scalp cooling.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1007/s00520-026-11377-4", "records": [ { "id": "scalp-cooling", "kind": "technology", "name": "Scalp cooling", "url": "https://onco.cc/technologies/scalp-cooling/" } ] } }, { "id": "https://doi.org/10.1007/s11033-026-12991-5#onco-edge-paper", "url": "https://doi.org/10.1007/s11033-026-12991-5", "title": "Hypoxia-induced GP73 promotes the Warburg effect in hepatocellular carcinoma via HIF-1α.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched Transarterial chemoembolisation, Oligonucleotide therapeutics and HIF-1α.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1007/s11033-026-12991-5", "records": [ { "id": "tace", "kind": "technology", "name": "Transarterial chemoembolisation", "url": "https://onco.cc/technologies/tace/" }, { "id": "antisense-sirna", "kind": "technology", "name": "Oligonucleotide therapeutics", "url": "https://onco.cc/technologies/antisense-sirna/" }, { "id": "hif1a", "kind": "target", "name": "HIF-1α", "url": "https://onco.cc/targets/hif1a/" } ] } }, { "id": "https://doi.org/10.1016/j.cell.2026.09.058#onco-edge-paper", "url": "https://doi.org/10.1016/j.cell.2026.09.058", "title": "MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched State and Metformin as an anti-ageing drug after cancer.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1016/j.cell.2026.09.058", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "rejuv-frontier-metformin-ageing", "kind": "technology", "name": "Metformin as an anti-ageing drug after cancer", "url": "https://onco.cc/technologies/rejuv-frontier-metformin-ageing/" } ] } }, { "id": "https://doi.org/10.1128/jvi.00886-26#onco-edge-paper", "url": "https://doi.org/10.1128/jvi.00886-26", "title": "No-known-vector flaviviruses exhibit diverse replication and virulence phenotypes in mice.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched Interferon alpha receptor and IFNGR1.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1128/jvi.00886-26", "records": [ { "id": "ifnar1", "kind": "target", "name": "Interferon alpha receptor", "url": "https://onco.cc/targets/ifnar1/" }, { "id": "ifngr1", "kind": "target", "name": "IFNGR1", "url": "https://onco.cc/targets/ifngr1/" } ] } }, { "id": "https://onco.cc/newsletter/2026-10-22/#onco-edge-issue", "url": "https://onco.cc/newsletter/2026-10-22/", "title": "OnCo weekly, 2026-10-22", "content_text": "1043 changelog entries, 1 upcoming date, 1 correction.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "issue" ], "_onco": { "kind": "issue", "date": "2026-10-22", "precision": "day", "venue": "OnCo weekly issue", "records": [] } }, { "id": "https://doi.org/10.1038/s41592-026-03262-z#onco-edge-paper", "url": "https://doi.org/10.1038/s41592-026-03262-z", "title": "OpenDVP: an experimental and computational framework for community-empowered deep visual proteomics.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, Proteomics & phosphoproteomics and Nicheformer.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1038/s41592-026-03262-z", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" }, { "id": "nicheformer", "kind": "technology", "name": "Nicheformer", "url": "https://onco.cc/technologies/nicheformer/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.1016/j.jid.2026.08.033#onco-edge-paper", "url": "https://doi.org/10.1016/j.jid.2026.08.033", "title": "Pathogenic Keratinocyte States and Fibroblast Niches Define the Tissue Microenvironment in Severe Hidradenitis Suppurativa.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and Spatial transcriptomics.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1016/j.jid.2026.08.033", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "spatial-transcriptomics", "kind": "technology", "name": "Spatial transcriptomics", "url": "https://onco.cc/technologies/spatial-transcriptomics/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.1111/bpa.70161#onco-edge-paper", "url": "https://doi.org/10.1111/bpa.70161", "title": "Protective role of Galectin-3 in prion disease through regulation of microglial PrP<sup>Sc</sup> uptake.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched NR4A3.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1111/bpa.70161", "records": [ { "id": "nr4a3", "kind": "target", "name": "NR4A3", "url": "https://onco.cc/targets/nr4a3/" } ] } }, { "id": "https://doi.org/10.1007/s00429-026-03213-6#onco-edge-paper", "url": "https://doi.org/10.1007/s00429-026-03213-6", "title": "Quantifying dexterity and grip strength associations between age, cognitive function (MoCA), and cerebellar gray matter volume in healthy adults across the adult lifespan.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched Atlas.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1007/s00429-026-03213-6", "records": [ { "id": "atlas-aignostics", "kind": "technology", "name": "Atlas", "url": "https://onco.cc/technologies/atlas-aignostics/" } ] } }, { "id": "https://doi.org/10.1007/s00418-026-02547-w#onco-edge-paper", "url": "https://doi.org/10.1007/s00418-026-02547-w", "title": "Toll-like receptor expression across histological states of epidermodysplasia verruciformis.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched LATS1.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1007/s00418-026-02547-w", "records": [ { "id": "lats1", "kind": "target", "name": "LATS1", "url": "https://onco.cc/targets/lats1/" } ] } }, { "id": "https://doi.org/10.1038/s41467-026-78394-z#onco-edge-paper", "url": "https://doi.org/10.1038/s41467-026-78394-z", "title": "XIST drives X-chromosome inactivation and safeguards female extraembryonic cells in humans.", "content_text": "Published on 22 October 2026 after first appearing as a preprint; matched DNA methylation profiling and State.", "date_published": "2026-10-22T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-22", "precision": "day", "doi": "10.1038/s41467-026-78394-z", "records": [ { "id": "methylation-profiling", "kind": "technology", "name": "DNA methylation profiling", "url": "https://onco.cc/technologies/methylation-profiling/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.1001/jamaoncol.2026.4298#onco-edge-paper", "url": "https://doi.org/10.1001/jamaoncol.2026.4298", "title": "Additional Analyses to Address Model Used to Adjust for Crossover in the ClarIDHy Trial.", "content_text": "Published in JAMA Oncol on 15 October 2026; found by the roadmap watch for ClarIDHy.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "JAMA Oncol", "doi": "10.1001/jamaoncol.2026.4298", "records": [ { "id": "claridhy", "kind": "trial", "name": "ClarIDHy", "url": "https://onco.cc/trials/claridhy/" }, { "id": "epigenetics-roadmap", "kind": "roadmap", "name": "Epigenetic therapy roadmap: loosening silenced genes → mutation-specific enzymes → editing the epigenome", "url": "https://onco.cc/roadmaps/epigenetics-roadmap/" } ] } }, { "id": "https://doi.org/10.1158/2159-8290.cd-26-0187#onco-edge-paper", "url": "https://doi.org/10.1158/2159-8290.cd-26-0187", "title": "Cabergoline Suppresses Postpartum Breast Cancer by Enhancing Mammary Gland Involution in Brca1-Mutant Mice and Is Associated with Reduced Risk in Younger Women.", "content_text": "Published in Cancer Discov on 15 October 2026; matched the OnCo record for Cabergoline.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cancer Discov", "doi": "10.1158/2159-8290.cd-26-0187", "records": [ { "id": "cabergoline", "kind": "drug", "name": "Cabergoline", "url": "https://onco.cc/drugs/cabergoline/" } ] } }, { "id": "https://doi.org/10.1126/science.aem9151#onco-edge-paper", "url": "https://doi.org/10.1126/science.aem9151", "title": "Erratum for the Research Article \"Enabling sustainable supply of the essential cancer medicines etoposide and teniposide in yeast\".", "content_text": "Published in Science on 15 October 2026; matched the OnCo record for Teniposide.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Science", "doi": "10.1126/science.aem9151", "records": [ { "id": "teniposide", "kind": "drug", "name": "Teniposide", "url": "https://onco.cc/drugs/teniposide/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.09.015#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.09.015", "title": "Gastric and oesophageal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.", "content_text": "Published in Ann Oncol on 15 October 2026; matched the OnCo record for Oesophageal cancer.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.09.015", "records": [ { "id": "esophageal", "kind": "cancer", "name": "Oesophageal cancer", "url": "https://onco.cc/cancers/esophageal/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-atezolizumab-combination-chemotherapy-stage-iii-mismatch-repair-deficient-colon-cancer#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-atezolizumab-combination-chemotherapy-stage-iii-mismatch-repair-deficient-colon-cancer", "title": "FDA approves atezolizumab in combination with chemotherapy for Stage III mismatch repair deficient colon cancer", "content_text": "On October 8, 2026, the Food and Drug Administration approved atezolizumab (Tecentriq, Genentech, Inc.) in combination with a fluoropyrimidine and oxaliplatin for the adjuvant treatment of adult and pediatric patients two years of age and older with Stage III mismatch repair deficient (dMMR) colon cancer.", "date_published": "2026-10-08T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-10-08", "precision": "day", "venue": "FDA", "records": [ { "id": "atezolizumab", "kind": "drug", "name": "Atezolizumab", "url": "https://onco.cc/drugs/atezolizumab/" }, { "id": "oxaliplatin", "kind": "drug", "name": "Oxaliplatin", "url": "https://onco.cc/drugs/oxaliplatin/" }, { "id": "colon-cancer", "kind": "cancer", "name": "Colon cancer", "url": "https://onco.cc/cancers/colon-cancer/" } ] } }, { "id": "https://doi.org/10.1016/j.ijrobp.2026.10.019#onco-edge-paper", "url": "https://doi.org/10.1016/j.ijrobp.2026.10.019", "title": "Acute activation of autophagy enables growth plate regeneration following radiation-induced injury.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched Cxbladder, PSMC4 and RPS6.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1016/j.ijrobp.2026.10.019", "records": [ { "id": "cxbladder", "kind": "drug", "name": "Cxbladder", "url": "https://onco.cc/drugs/cxbladder/" }, { "id": "psmc4", "kind": "target", "name": "PSMC4", "url": "https://onco.cc/targets/psmc4/" }, { "id": "rps6", "kind": "target", "name": "RPS6", "url": "https://onco.cc/targets/rps6/" }, { "id": "sox9", "kind": "target", "name": "SOX9", "url": "https://onco.cc/targets/sox9/" }, { "id": "sqstm1", "kind": "target", "name": "SQSTM1", "url": "https://onco.cc/targets/sqstm1/" } ] } }, { "id": "https://doi.org/10.1186/s12879-026-14689-2#onco-edge-paper", "url": "https://doi.org/10.1186/s12879-026-14689-2", "title": "Antimicrobial resistance and documented empirical antibiotic prescribing among cancer patients with culture-confirmed infections at a tertiary referral hospital in Rwanda, 2019-2024.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched EDNRA.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1186/s12879-026-14689-2", "records": [ { "id": "ednra", "kind": "target", "name": "EDNRA", "url": "https://onco.cc/targets/ednra/" } ] } }, { "id": "https://doi.org/10.1523/jneurosci.0240-26.2026#onco-edge-paper", "url": "https://doi.org/10.1523/jneurosci.0240-26.2026", "title": "ASCL1 and OLIG2 Expression Dynamics Control Glial Cell Fate and Regional Diversity in the Dorsal Forebrain.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched State, ASCL1 and OLIG2.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1523/jneurosci.0240-26.2026", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "ascl1", "kind": "target", "name": "ASCL1", "url": "https://onco.cc/targets/ascl1/" }, { "id": "olig2", "kind": "target", "name": "OLIG2", "url": "https://onco.cc/targets/olig2/" } ] } }, { "id": "https://doi.org/10.1186/s13020-026-01449-2#onco-edge-paper", "url": "https://doi.org/10.1186/s13020-026-01449-2", "title": "Astragali Radix-Curcumae Rhizoma synergistically potentiates 5-fluorouracil antitumor efficacy in colorectal cancer by disrupting DNA repair-cell cycle coordination.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, AKT and BRCA1 / BRCA2.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1186/s13020-026-01449-2", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "akt", "kind": "target", "name": "AKT", "url": "https://onco.cc/targets/akt/" }, { "id": "brca", "kind": "target", "name": "BRCA1 / BRCA2", "url": "https://onco.cc/targets/brca/" }, { "id": "fluorouracil", "kind": "drug", "name": "Fluorouracil", "url": "https://onco.cc/drugs/fluorouracil/" }, { "id": "mmr", "kind": "target", "name": "Mismatch repair proteins", "url": "https://onco.cc/targets/mmr/" }, { "id": "msh2", "kind": "target", "name": "MSH2", "url": "https://onco.cc/targets/msh2/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aej4603#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aej4603", "title": "BCG vaccination mitigates tau pathology and restores cognitive function in PS19 mice.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched MRI, RNA sequencing & expression profiling and State.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1126/sciadv.aej4603", "records": [ { "id": "mri", "kind": "technology", "name": "MRI", "url": "https://onco.cc/technologies/mri/" }, { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "cd80", "kind": "target", "name": "CD80", "url": "https://onco.cc/targets/cd80/" } ] } }, { "id": "https://doi.org/10.1073/pnas.2612742123#onco-edge-paper", "url": "https://doi.org/10.1073/pnas.2612742123", "title": "CD28 costimulation is organized by signaling condensates and counteracted by PD-1.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched PD-1, SRC family kinases and CD28.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1073/pnas.2612742123", "records": [ { "id": "pd1", "kind": "target", "name": "PD-1", "url": "https://onco.cc/targets/pd1/" }, { "id": "src", "kind": "target", "name": "SRC family kinases", "url": "https://onco.cc/targets/src/" }, { "id": "cd28", "kind": "target", "name": "CD28", "url": "https://onco.cc/targets/cd28/" }, { "id": "lck", "kind": "target", "name": "LCK", "url": "https://onco.cc/targets/lck/" }, { "id": "grb2", "kind": "target", "name": "GRB2", "url": "https://onco.cc/targets/grb2/" } ] } }, { "id": "https://doi.org/10.1093/nargab/lqag128#onco-edge-paper", "url": "https://doi.org/10.1093/nargab/lqag128", "title": "Cell DiffErential Expression by Pooling (CellDEEP) highlights issues in differential gene expression in scRNA-seq.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and Single-cell & spatial profiling.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1093/nargab/lqag128", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.3390/cells15201914#onco-edge-paper", "url": "https://doi.org/10.3390/cells15201914", "title": "Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics and HLA-A.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.3390/cells15201914", "records": [ { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" }, { "id": "hla-a", "kind": "target", "name": "HLA-A", "url": "https://onco.cc/targets/hla-a/" } ] } }, { "id": "https://doi.org/10.1038/s41587-026-03348-1#onco-edge-paper", "url": "https://doi.org/10.1038/s41587-026-03348-1", "title": "Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, State and ARID1A.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1038/s41587-026-03348-1", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "arid1a", "kind": "target", "name": "ARID1A", "url": "https://onco.cc/targets/arid1a/" }, { "id": "stat3", "kind": "target", "name": "STAT3", "url": "https://onco.cc/targets/stat3/" }, { "id": "ctcf", "kind": "target", "name": "CTCF", "url": "https://onco.cc/targets/ctcf/" }, { "id": "bcl6", "kind": "target", "name": "BCL6", "url": "https://onco.cc/targets/bcl6/" } ] } }, { "id": "https://doi.org/10.1038/s41467-026-78596-5#onco-edge-paper", "url": "https://doi.org/10.1038/s41467-026-78596-5", "title": "High-content morphological profiling by Cell Painting in 3D spheroids.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, PARP inhibitors and Olaparib.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1038/s41467-026-78596-5", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "parp-inhibitor", "kind": "technology", "name": "PARP inhibitors", "url": "https://onco.cc/technologies/parp-inhibitor/" }, { "id": "olaparib", "kind": "drug", "name": "Olaparib", "url": "https://onco.cc/drugs/olaparib/" }, { "id": "fluorouracil", "kind": "drug", "name": "Fluorouracil", "url": "https://onco.cc/drugs/fluorouracil/" } ] } }, { "id": "https://doi.org/10.1038/s41467-026-78430-y#onco-edge-paper", "url": "https://doi.org/10.1038/s41467-026-78430-y", "title": "HRDPath: an explainable multi-model deep learning architecture for predicting homologous recombination deficiency from histopathology images.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched HRD & BRCA testing and BRCA1 / BRCA2.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1038/s41467-026-78430-y", "records": [ { "id": "hrd-testing", "kind": "technology", "name": "HRD & BRCA testing", "url": "https://onco.cc/technologies/hrd-testing/" }, { "id": "brca", "kind": "target", "name": "BRCA1 / BRCA2", "url": "https://onco.cc/targets/brca/" } ] } }, { "id": "https://doi.org/10.1093/protein/gzag030#onco-edge-paper", "url": "https://doi.org/10.1093/protein/gzag030", "title": "Improved Calreticulin Nanobody by Framework Engineering.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched HER2 and CALR.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1093/protein/gzag030", "records": [ { "id": "her2", "kind": "target", "name": "HER2", "url": "https://onco.cc/targets/her2/" }, { "id": "calr", "kind": "target", "name": "CALR", "url": "https://onco.cc/targets/calr/" } ] } }, { "id": "https://doi.org/10.3390/ijms27209340#onco-edge-paper", "url": "https://doi.org/10.3390/ijms27209340", "title": "Interferon-Induced Protein 6 (IFI6): Biological Functions, Molecular Mechanisms and Pathological Roles in Human Diseases.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched EGFR, AKT and BCL-2.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.3390/ijms27209340", "records": [ { "id": "egfr", "kind": "target", "name": "EGFR", "url": "https://onco.cc/targets/egfr/" }, { "id": "akt", "kind": "target", "name": "AKT", "url": "https://onco.cc/targets/akt/" }, { "id": "bcl2", "kind": "target", "name": "BCL-2", "url": "https://onco.cc/targets/bcl2/" }, { "id": "tretinoin-atra", "kind": "drug", "name": "Tretinoin", "url": "https://onco.cc/drugs/tretinoin-atra/" }, { "id": "bim", "kind": "target", "name": "BIM", "url": "https://onco.cc/targets/bim/" }, { "id": "egf", "kind": "target", "name": "EGF", "url": "https://onco.cc/targets/egf/" } ] } }, { "id": "https://onco.cc/newsletter/2026-10-21/#onco-edge-issue", "url": "https://onco.cc/newsletter/2026-10-21/", "title": "OnCo weekly, 2026-10-21", "content_text": "1030 changelog entries, 1 upcoming date, 1 correction.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "issue" ], "_onco": { "kind": "issue", "date": "2026-10-21", "precision": "day", "venue": "OnCo weekly issue", "records": [] } }, { "id": "https://doi.org/10.1002/acn3.70559#onco-edge-paper", "url": "https://doi.org/10.1002/acn3.70559", "title": "PCGF1 Promotes the Tumorigenesis of Malignancies Through Upregulating CCDC34 in Glioma.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and SET.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1002/acn3.70559", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "set", "kind": "target", "name": "SET", "url": "https://onco.cc/targets/set/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aed2741#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aed2741", "title": "Single-cell-level digital twins for preterm birth prevention strategies.", "content_text": "Published on 21 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling, Atlas and mTOR.", "date_published": "2026-10-21T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-21", "precision": "day", "doi": "10.1126/sciadv.aed2741", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "atlas-aignostics", "kind": "technology", "name": "Atlas", "url": "https://onco.cc/technologies/atlas-aignostics/" }, { "id": "mtor", "kind": "target", "name": "mTOR", "url": "https://onco.cc/targets/mtor/" }, { "id": "cd4", "kind": "target", "name": "CD4", "url": "https://onco.cc/targets/cd4/" }, { "id": "aspirin", "kind": "drug", "name": "Aspirin", "url": "https://onco.cc/drugs/aspirin/" } ] } }, { "id": "https://doi.org/10.1038/s41586-026-11150-x#onco-edge-paper", "url": "https://doi.org/10.1038/s41586-026-11150-x", "title": "Divergent genomic evolution in astrocytomas and oligodendrogliomas.", "content_text": "Published in Nature on 14 October 2026; matched the OnCo record for CDKN2B.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "Nature", "doi": "10.1038/s41586-026-11150-x", "records": [ { "id": "cdkn2b", "kind": "target", "name": "CDKN2B", "url": "https://onco.cc/targets/cdkn2b/" } ] } }, { "id": "https://doi.org/10.1200/jco-25-02730#onco-edge-paper", "url": "https://doi.org/10.1200/jco-25-02730", "title": "Dose-Escalated Focal Salvage High-Dose-Rate Brachytherapy and Genomic Classifier Risk Stratification in Radiorecurrent Prostate Cancer: The F-SHARP Phase I/II Clinical Trial.", "content_text": "Published in J Clin Oncol on 14 October 2026; matched the OnCo record for High-dose-rate brachytherapy.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "J Clin Oncol", "doi": "10.1200/jco-25-02730", "records": [ { "id": "hdr-brachytherapy", "kind": "technology", "name": "High-dose-rate brachytherapy", "url": "https://onco.cc/technologies/hdr-brachytherapy/" } ] } }, { "id": "https://doi.org/10.1038/s41586-026-11112-3#onco-edge-paper", "url": "https://doi.org/10.1038/s41586-026-11112-3", "title": "Elp1 is required for myeloid differentiation and brain repopulation.", "content_text": "Published in Nature on 14 October 2026; matched the OnCo record for ELP1.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "Nature", "doi": "10.1038/s41586-026-11112-3", "records": [ { "id": "elp1", "kind": "target", "name": "ELP1", "url": "https://onco.cc/targets/elp1/" } ] } }, { "id": "https://doi.org/10.1016/j.annonc.2026.10.101#onco-edge-paper", "url": "https://doi.org/10.1016/j.annonc.2026.10.101", "title": "Emerging Therapeutic targets and Early-phase drug Development in Gynecological Malignancies.", "content_text": "Published in Ann Oncol on 14 October 2026; matched the OnCo record for WEE1.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "Ann Oncol", "doi": "10.1016/j.annonc.2026.10.101", "records": [ { "id": "wee1", "kind": "target", "name": "WEE1", "url": "https://onco.cc/targets/wee1/" }, { "id": "wrn", "kind": "target", "name": "WRN helicase", "url": "https://onco.cc/targets/wrn/" } ] } }, { "id": "https://doi.org/10.1038/s41591-026-04717-8#onco-edge-paper", "url": "https://doi.org/10.1038/s41591-026-04717-8", "title": "Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial.", "content_text": "Published in Nat Med on 14 October 2026; matched the OnCo record for NeoVax.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "Nat Med", "doi": "10.1038/s41591-026-04717-8", "records": [ { "id": "neovax", "kind": "drug", "name": "NeoVax", "url": "https://onco.cc/drugs/neovax/" }, { "id": "platinum-sensitive-ovarian-cancer", "kind": "cancer", "name": "Platinum-sensitive ovarian cancer", "url": "https://onco.cc/cancers/platinum-sensitive-ovarian-cancer/" } ] } }, { "id": "https://doi.org/10.1200/jco-25-03013#onco-edge-paper", "url": "https://doi.org/10.1200/jco-25-03013", "title": "Selpercatinib in Pediatric and Adolescent Patients With <i>RET</i>-Altered Solid Tumors: Safety and Efficacy Results From the Phase I/II LIBRETTO-121 Study.", "content_text": "Published in J Clin Oncol on 14 October 2026; matched the OnCo record for Selpercatinib.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "J Clin Oncol", "doi": "10.1200/jco-25-03013", "records": [ { "id": "selpercatinib", "kind": "drug", "name": "Selpercatinib", "url": "https://onco.cc/drugs/selpercatinib/" } ] } }, { "id": "https://doi.org/10.1038/s41591-026-04671-5#onco-edge-paper", "url": "https://doi.org/10.1038/s41591-026-04671-5", "title": "Talazoparib plus enzalutamide in high-volume metastatic hormone-naive prostate cancer: a randomized phase 2 trial.", "content_text": "Published in Nat Med on 14 October 2026; matched the OnCo record for Talazoparib.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "Nat Med", "doi": "10.1038/s41591-026-04671-5", "records": [ { "id": "talazoparib", "kind": "drug", "name": "Talazoparib", "url": "https://onco.cc/drugs/talazoparib/" } ] } }, { "id": "https://doi.org/10.1200/jco-26-02462#onco-edge-paper", "url": "https://doi.org/10.1200/jco-26-02462", "title": "Treatment of Advanced Biliary Tract Cancer: ASCO Living Guideline, Version 2026.1.0.", "content_text": "Published in J Clin Oncol on 14 October 2026; matched the OnCo record for NRG1.", "date_published": "2026-10-14T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-14", "precision": "day", "venue": "J Clin Oncol", "doi": "10.1200/jco-26-02462", "records": [ { "id": "nrg1", "kind": "target", "name": "NRG1", "url": "https://onco.cc/targets/nrg1/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tucatinib-trastuzumab-and-pertuzumab-maintenance-treatment-her2-positive-breast-cancer#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tucatinib-trastuzumab-and-pertuzumab-maintenance-treatment-her2-positive-breast-cancer", "title": "FDA approves tucatinib with trastuzumab and pertuzumab for the maintenance treatment of HER2-positive breast cancer", "content_text": "On October 7, 2026, the Food and Drug Administration approved tucatinib (Tukysa, Seagen Inc., a subsidiary of Pfizer) in combination with trastuzumab and pertuzumab for the maintenance treatment of adults with unresectable locally advanced or metastatic HER2-positive breast cancer following induction treatment.", "date_published": "2026-10-07T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-10-07", "precision": "day", "venue": "FDA", "records": [ { "id": "trastuzumab", "kind": "drug", "name": "Trastuzumab", "url": "https://onco.cc/drugs/trastuzumab/" }, { "id": "pertuzumab", "kind": "drug", "name": "Pertuzumab", "url": "https://onco.cc/drugs/pertuzumab/" }, { "id": "tucatinib", "kind": "drug", "name": "Tucatinib", "url": "https://onco.cc/drugs/tucatinib/" }, { "id": "breast-her2-positive", "kind": "cancer", "name": "HER2-positive breast cancer", "url": "https://onco.cc/cancers/breast-her2-positive/" }, { "id": "breast-cancer", "kind": "cancer", "name": "Breast cancer", "url": "https://onco.cc/cancers/breast-cancer/" } ] } }, { "id": "https://doi.org/10.20944/preprints202610.2607.v1#onco-edge-preprint", "url": "https://doi.org/10.20944/preprints202610.2607.v1", "title": "Value of Air-Flush Recovery (ATR) of Needle-Tract Residual Tissue for Establishing Pancreatic Cancer Organoids via EUS-FNA", "content_text": "Posted on Preprints.org on 27 October 2026; not peer reviewed; matched Ultrasound, Patient-derived organoids and ATR.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Preprints.org", "doi": "10.20944/preprints202610.2607.v1", "records": [ { "id": "ultrasound", "kind": "technology", "name": "Ultrasound", "url": "https://onco.cc/technologies/ultrasound/" }, { "id": "organoids", "kind": "technology", "name": "Patient-derived organoids", "url": "https://onco.cc/technologies/organoids/" }, { "id": "atr", "kind": "target", "name": "ATR", "url": "https://onco.cc/targets/atr/" }, { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11486198/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11486198/v1", "title": "A preregistered test that outcome-permuted data also pass: mathematical coupling in a pan-cancer analysis of proliferation adjustment in prognostic gene expression studies", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched MET and SET.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11486198/v1", "records": [ { "id": "met", "kind": "target", "name": "MET", "url": "https://onco.cc/targets/met/" }, { "id": "set", "kind": "target", "name": "SET", "url": "https://onco.cc/targets/set/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-10591507/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-10591507/v1", "title": "A Single-Arm Phase II Clinical Study of SBRT Combined with Tislelizumab and GM-CSF for Advanced Non-Small Cell Lung Cancer Progressing After Immunotherapy", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Tislelizumab, Nintedanib and SBRT / SABR.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-10591507/v1", "records": [ { "id": "tislelizumab", "kind": "drug", "name": "Tislelizumab", "url": "https://onco.cc/drugs/tislelizumab/" }, { "id": "nintedanib", "kind": "drug", "name": "Nintedanib", "url": "https://onco.cc/drugs/nintedanib/" }, { "id": "sbrt", "kind": "technology", "name": "SBRT / SABR", "url": "https://onco.cc/technologies/sbrt/" }, { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11073113/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11073113/v1", "title": "Abnormal Uterine Bleeding in Female Kidney Transplant Recipients: A Cross-Sectional Study Using the FIGO PALM- COEIN Classification", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Prednisone and mTOR.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11073113/v1", "records": [ { "id": "prednisone", "kind": "drug", "name": "Prednisone", "url": "https://onco.cc/drugs/prednisone/" }, { "id": "mtor", "kind": "target", "name": "mTOR", "url": "https://onco.cc/targets/mtor/" } ] } }, { "id": "https://doi.org/10.20944/preprints202610.2642.v1#onco-edge-preprint", "url": "https://doi.org/10.20944/preprints202610.2642.v1", "title": "Advances and Translational Challenges in mRNA–Lipid Nanoparticle Vaccines Against Helicobacter pylori: From Rational Antigen Design to Mucosal Immunity", "content_text": "Posted on Preprints.org on 27 October 2026; not peer reviewed; matched Azacitidine, Decitabine + cedazuridine and Tretinoin.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Preprints.org", "doi": "10.20944/preprints202610.2642.v1", "records": [ { "id": "azacitidine", "kind": "drug", "name": "Azacitidine", "url": "https://onco.cc/drugs/azacitidine/" }, { "id": "decitabine-cedazuridine", "kind": "drug", "name": "Decitabine + cedazuridine", "url": "https://onco.cc/drugs/decitabine-cedazuridine/" }, { "id": "tretinoin-atra", "kind": "drug", "name": "Tretinoin", "url": "https://onco.cc/drugs/tretinoin-atra/" }, { "id": "cd4", "kind": "target", "name": "CD4", "url": "https://onco.cc/targets/cd4/" }, { "id": "cd8", "kind": "target", "name": "CD8", "url": "https://onco.cc/targets/cd8/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.23.761404#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.23.761404", "title": "Amino Acid Remodeling Precedes Malignant Transformation in Oral Epithelial Cells", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched Azacitidine, Decitabine + cedazuridine and Proteomics & phosphoproteomics.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.23.761404", "records": [ { "id": "azacitidine", "kind": "drug", "name": "Azacitidine", "url": "https://onco.cc/drugs/azacitidine/" }, { "id": "decitabine-cedazuridine", "kind": "drug", "name": "Decitabine + cedazuridine", "url": "https://onco.cc/drugs/decitabine-cedazuridine/" }, { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" }, { "id": "chemoprevention", "kind": "technology", "name": "Chemoprevention & risk-reducing surgery", "url": "https://onco.cc/technologies/chemoprevention/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11353197/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11353197/v1", "title": "An Upgraded Arsenic Trioxide–Based Salvage Regimen for Relapsed or Refractory Neuroblastoma: Improved Disease Control and Genomic Alterations", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched ALK, Arsenic trioxide and MYCN.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11353197/v1", "records": [ { "id": "alk", "kind": "target", "name": "ALK", "url": "https://onco.cc/targets/alk/" }, { "id": "arsenic-trioxide", "kind": "drug", "name": "Arsenic trioxide", "url": "https://onco.cc/drugs/arsenic-trioxide/" }, { "id": "mycn", "kind": "target", "name": "MYCN", "url": "https://onco.cc/targets/mycn/" }, { "id": "quantitative-imaging-biomarkers", "kind": "technology", "name": "Quantitative imaging biomarkers", "url": "https://onco.cc/technologies/quantitative-imaging-biomarkers/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.24.761494#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.24.761494", "title": "Anti-Nucleolin Aptamer iSN04 Inhibits Alveolar Rhabdomyosarcoma Cell Growth by Inducing Myogenic Differentiation", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched Vincristine, ID3 and CASZ1.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.24.761494", "records": [ { "id": "vincristine", "kind": "drug", "name": "Vincristine", "url": "https://onco.cc/drugs/vincristine/" }, { "id": "id3", "kind": "target", "name": "ID3", "url": "https://onco.cc/targets/id3/" }, { "id": "casz1", "kind": "target", "name": "CASZ1", "url": "https://onco.cc/targets/casz1/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11071154/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11071154/v1", "title": "Application of a Multimodal Prehabilitaion and Rehabilitaion Program for Patients Undergoing Liver Cancer Resection", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Azacitidine, Decitabine + cedazuridine and MET.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11071154/v1", "records": [ { "id": "azacitidine", "kind": "drug", "name": "Azacitidine", "url": "https://onco.cc/drugs/azacitidine/" }, { "id": "decitabine-cedazuridine", "kind": "drug", "name": "Decitabine + cedazuridine", "url": "https://onco.cc/drugs/decitabine-cedazuridine/" }, { "id": "met", "kind": "target", "name": "MET", "url": "https://onco.cc/targets/met/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11350385/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11350385/v1", "title": "Assessment of the Clinical Role of Serum Levels of IL-1, VEGF, and MMP-2 in the Detection of Radiation Pneumonitis and Prediction of Its Occurrence in Breast Cancer Females Treated with Radiotherapy", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched MMP2.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11350385/v1", "records": [ { "id": "mmp2", "kind": "target", "name": "MMP2", "url": "https://onco.cc/targets/mmp2/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.22.760895#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.22.760895", "title": "Astatine-211 injury induces an immunostimulatory melanoma-cell state and promotes systemic antitumor immunity", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Targeted alpha therapy and Etoposide.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.22.760895", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "targeted-alpha-therapy", "kind": "technology", "name": "Targeted alpha therapy", "url": "https://onco.cc/technologies/targeted-alpha-therapy/" }, { "id": "etoposide", "kind": "drug", "name": "Etoposide", "url": "https://onco.cc/drugs/etoposide/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.22.760906#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.22.760906", "title": "CATFISHR: integration of transcriptome and inferred CNV profiles for comprehensive malignant cell identification", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and MRD / molecular residual disease testing.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.22.760906", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "mrd-testing", "kind": "technology", "name": "MRD / molecular residual disease testing", "url": "https://onco.cc/technologies/mrd-testing/" }, { "id": "spatial-transcriptomics", "kind": "technology", "name": "Spatial transcriptomics", "url": "https://onco.cc/technologies/spatial-transcriptomics/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.23.761323#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.23.761323", "title": "CBX3 Deletion Overcomes Ferroptosis Resistance in Colorectal Cancer by Targeting IFNγ/SLC7A11/SLC3A2 Axis", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched COX-2 and STAT1.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.23.761323", "records": [ { "id": "cox2", "kind": "target", "name": "COX-2", "url": "https://onco.cc/targets/cox2/" }, { "id": "stat1", "kind": "target", "name": "STAT1", "url": "https://onco.cc/targets/stat1/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.23.761417#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.23.761417", "title": "Cell-type resolved prenylomics in mouse liver enabled by a low-input proteomics workflow", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched Pertuzumab and Proteomics & phosphoproteomics.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.23.761417", "records": [ { "id": "pertuzumab", "kind": "drug", "name": "Pertuzumab", "url": "https://onco.cc/drugs/pertuzumab/" }, { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.24.761574#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.24.761574", "title": "Computational Design and Evaluation of De Novo Protein Minibinders Targeting Specific Sites of STAT3", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched STAT3.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.24.761574", "records": [ { "id": "stat3", "kind": "target", "name": "STAT3", "url": "https://onco.cc/targets/stat3/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11076733/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11076733/v1", "title": "Cranial Nerve Outcomes After Primary or Adjuvant Gamma Knife Stereotactic Radiosurgery for Cavernous Sinus Meningiomas", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched NT5C2, Stereotactic radiosurgery and Gamma Knife.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11076733/v1", "records": [ { "id": "nt5c2", "kind": "target", "name": "NT5C2", "url": "https://onco.cc/targets/nt5c2/" }, { "id": "radiosurgery-srs", "kind": "technology", "name": "Stereotactic radiosurgery", "url": "https://onco.cc/technologies/radiosurgery-srs/" }, { "id": "gamma-knife", "kind": "technology", "name": "Gamma Knife", "url": "https://onco.cc/technologies/gamma-knife/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11339202/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11339202/v1", "title": "CRISPR/Cas9-mediated knockout of AKAP12 gene increases susceptibility to doxorubicin in MCF-7/ADR breast cancer cell line", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Doxorubicin.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11339202/v1", "records": [ { "id": "doxorubicin", "kind": "drug", "name": "Doxorubicin", "url": "https://onco.cc/drugs/doxorubicin/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11307418/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11307418/v1", "title": "Development and Temporal Validation of an Interpretable Machine‑Learning Model for Risk‑Stratified Endoscopy Triage in Population‑Based Esophageal Squamous Cell Carcinoma Screening", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Azacitidine, Decitabine + cedazuridine and Cxbladder.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11307418/v1", "records": [ { "id": "azacitidine", "kind": "drug", "name": "Azacitidine", "url": "https://onco.cc/drugs/azacitidine/" }, { "id": "decitabine-cedazuridine", "kind": "drug", "name": "Decitabine + cedazuridine", "url": "https://onco.cc/drugs/decitabine-cedazuridine/" }, { "id": "cxbladder", "kind": "drug", "name": "Cxbladder", "url": "https://onco.cc/drugs/cxbladder/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-10951092/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-10951092/v1", "title": "Diagnostic Challenges in Atypical Spindle Cell Melanoma Simulating Malignant Peripheral Nerve Sheath Tumor", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched BRAF, NRAS and NF1.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-10951092/v1", "records": [ { "id": "braf", "kind": "target", "name": "BRAF", "url": "https://onco.cc/targets/braf/" }, { "id": "nras", "kind": "target", "name": "NRAS", "url": "https://onco.cc/targets/nras/" }, { "id": "nf1", "kind": "target", "name": "NF1", "url": "https://onco.cc/targets/nf1/" }, { "id": "sox10", "kind": "target", "name": "SOX10", "url": "https://onco.cc/targets/sox10/" }, { "id": "cd34", "kind": "target", "name": "CD34", "url": "https://onco.cc/targets/cd34/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.22.760478#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.22.760478", "title": "Disease-associated NK-cell state remodeling reveals transcriptional profiles predictive of clinical phenotypes", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched Immune checkpoint inhibitors.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.22.760478", "records": [ { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.26.762023#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.26.762023", "title": "Divide and conquer: a viral bifunctional RNA utilizes both RNA and protein to modulate pro-tumourigenic pathways", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched YES1.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.26.762023", "records": [ { "id": "yes1", "kind": "target", "name": "YES1", "url": "https://onco.cc/targets/yes1/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.25.26365062#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.25.26365062", "title": "Educational expectations and needs of individuals scheduled for breast surgery within the Primary Nursing Model: a qualitative study", "content_text": "Posted on medRxiv on 27 October 2026; not peer reviewed; matched CCDC6.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "medRxiv", "doi": "10.64898/2026.10.25.26365062", "records": [ { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11342340/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11342340/v1", "title": "Etanercept Withdrawal-Associated Regression of Nodal Marginal Zone Lymphoma in Rheumatoid Arthritis", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Methotrexate.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11342340/v1", "records": [ { "id": "methotrexate", "kind": "drug", "name": "Methotrexate", "url": "https://onco.cc/drugs/methotrexate/" } ] } }, { "id": "https://doi.org/10.20944/preprints202610.2619.v1#onco-edge-preprint", "url": "https://doi.org/10.20944/preprints202610.2619.v1", "title": "Evaluation of Optical-Spectroscopy Based Identification of Breast Abnormality / Lumps in Indian Population Using Brexwel Device", "content_text": "Posted on Preprints.org on 27 October 2026; not peer reviewed; matched Mammography & tomosynthesis and CCDC6.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Preprints.org", "doi": "10.20944/preprints202610.2619.v1", "records": [ { "id": "mammography", "kind": "technology", "name": "Mammography & tomosynthesis", "url": "https://onco.cc/technologies/mammography/" }, { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11294427/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11294427/v1", "title": "Extracellular vesicle-associated COMP from cancer-associated fibroblasts promotes ferroptosis resistance in hepatocellular carcinoma", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched HIF-1α and RANBP2.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11294427/v1", "records": [ { "id": "hif1a", "kind": "target", "name": "HIF-1α", "url": "https://onco.cc/targets/hif1a/" }, { "id": "ranbp2", "kind": "target", "name": "RANBP2", "url": "https://onco.cc/targets/ranbp2/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11303324/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11303324/v1", "title": "Factors Associated with Response to 177Lu-PSMA-617 Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer: A Retrospective Analysis", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched PET/CT, PSMA PET and Radioligand therapy.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11303324/v1", "records": [ { "id": "pet-ct", "kind": "technology", "name": "PET/CT", "url": "https://onco.cc/technologies/pet-ct/" }, { "id": "psma-pet", "kind": "technology", "name": "PSMA PET", "url": "https://onco.cc/technologies/psma-pet/" }, { "id": "radioligand-therapy", "kind": "technology", "name": "Radioligand therapy", "url": "https://onco.cc/technologies/radioligand-therapy/" }, { "id": "lu177-radioligand-therapy", "kind": "technology", "name": "Lutetium-177 radioligand therapy", "url": "https://onco.cc/technologies/lu177-radioligand-therapy/" }, { "id": "psma", "kind": "target", "name": "PSMA", "url": "https://onco.cc/targets/psma/" }, { "id": "pluvicto", "kind": "drug", "name": "Lutetium-177 vipivotide tetraxetan", "url": "https://onco.cc/drugs/pluvicto/" } ] } }, { "id": "https://doi.org/10.20944/preprints202610.2644.v1#onco-edge-preprint", "url": "https://doi.org/10.20944/preprints202610.2644.v1", "title": "Faecal Microbiota Transplantation in Paediatric Haematopoietic Stem Cell Transplantation: Current Evidence, Safety, and Future Directions", "content_text": "Posted on Preprints.org on 27 October 2026; not peer reviewed; matched CCDC6.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Preprints.org", "doi": "10.20944/preprints202610.2644.v1", "records": [ { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-10797928/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-10797928/v1", "title": "Favorable Survival and Manageable Toxicity With Consolidative Radiotherapy to the Residual Primary Tumor After First-Line Chemoimmunotherapy in Metastatic NSCLC", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Nintedanib.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-10797928/v1", "records": [ { "id": "nintedanib", "kind": "drug", "name": "Nintedanib", "url": "https://onco.cc/drugs/nintedanib/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-9341537/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-9341537/v1", "title": "First-in-Human Phase 1/2 Study of Cafelkibart, an Anti-CCR8 Monoclonal Antibody, as Monotherapy or in Combination with PD-1 Inhibition in Solid Tumors", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Monoclonal antibodies and PD-1.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-9341537/v1", "records": [ { "id": "monoclonal-antibody", "kind": "technology", "name": "Monoclonal antibodies", "url": "https://onco.cc/technologies/monoclonal-antibody/" }, { "id": "pd1", "kind": "target", "name": "PD-1", "url": "https://onco.cc/targets/pd1/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11447687/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11447687/v1", "title": "First-in-human quad-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched CAR-T cell therapy, HER2 and B7-H3.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11447687/v1", "records": [ { "id": "car-t", "kind": "technology", "name": "CAR-T cell therapy", "url": "https://onco.cc/technologies/car-t/" }, { "id": "her2", "kind": "target", "name": "HER2", "url": "https://onco.cc/targets/her2/" }, { "id": "b7h3", "kind": "target", "name": "B7-H3", "url": "https://onco.cc/targets/b7h3/" }, { "id": "h3c14", "kind": "target", "name": "H3C14", "url": "https://onco.cc/targets/h3c14/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.27.26366415#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.27.26366415", "title": "From non-uptake during early adolescence to acceptance during a catch-up campaign: a qualitative study of changing HPV vaccination decisions across two life stages among young women in Amsterdam, the Netherlands", "content_text": "Posted on medRxiv on 27 October 2026; not peer reviewed; matched HPV & HBV vaccination.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "medRxiv", "doi": "10.64898/2026.10.27.26366415", "records": [ { "id": "hpv-vaccine", "kind": "technology", "name": "HPV & HBV vaccination", "url": "https://onco.cc/technologies/hpv-vaccine/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.26.759860#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.26.759860", "title": "Genetic drivers shape TREM2-dependent myeloid responses and glioblastoma progression", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and State.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.26.759860", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "nf1", "kind": "target", "name": "NF1", "url": "https://onco.cc/targets/nf1/" }, { "id": "pdgfb", "kind": "target", "name": "PDGFB", "url": "https://onco.cc/targets/pdgfb/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11496712/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11496712/v1", "title": "Giant High-Grade Myxofibrosarcoma of the Right Thigh Treated by Hip Disarticulation: A Case Report with Imaging–Pathology Correlation", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Ifosfamide.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11496712/v1", "records": [ { "id": "ifosfamide", "kind": "drug", "name": "Ifosfamide", "url": "https://onco.cc/drugs/ifosfamide/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11490262/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11490262/v1", "title": "Heptyl prodigiosin from estuarine Zooshikella sp. RANM57 induces caspase-dependent apoptosis and suppresses clonogenic survival in androgen-independent prostate cancer cells", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Cisplatin and Platinum agents.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11490262/v1", "records": [ { "id": "cisplatin", "kind": "drug", "name": "Cisplatin", "url": "https://onco.cc/drugs/cisplatin/" }, { "id": "platinum", "kind": "technology", "name": "Platinum agents", "url": "https://onco.cc/technologies/platinum/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11469296/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11469296/v1", "title": "Impact of Surgical Timing on Outcomes in Locally Advanced Rectal Cancer: A Retrospective Study in a Resource-Limited Setting", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched ELL.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11469296/v1", "records": [ { "id": "ell", "kind": "target", "name": "ELL", "url": "https://onco.cc/targets/ell/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.23.761433#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.23.761433", "title": "Inferring somatic copy number aberrations from spatial transcriptomics data to study early cancer development", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched Single-cell & spatial profiling and Spatial transcriptomics.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.23.761433", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "spatial-transcriptomics", "kind": "technology", "name": "Spatial transcriptomics", "url": "https://onco.cc/technologies/spatial-transcriptomics/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-10992120/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-10992120/v1", "title": "Integrated single cell and bulk transcriptomic analysis reveals disulfidptosis related malignant epithelial states associated with prognosis in gastric cancer", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched RNA sequencing & expression profiling and Single-cell & spatial profiling.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-10992120/v1", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.23.761315#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.23.761315", "title": "Integrative Single-Cell Transcriptomics and Explainable AI for Disease Mechanism and Biomarker Discovery in Triple-Negative Breast Cancer", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and KRAS.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.23.761315", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "kras", "kind": "target", "name": "KRAS", "url": "https://onco.cc/targets/kras/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "tgfbr2", "kind": "target", "name": "TGFBR2", "url": "https://onco.cc/targets/tgfbr2/" }, { "id": "wwtr1", "kind": "target", "name": "WWTR1", "url": "https://onco.cc/targets/wwtr1/" } ] } }, { "id": "https://doi.org/10.21203/rs.3.rs-11133121/v1#onco-edge-preprint", "url": "https://doi.org/10.21203/rs.3.rs-11133121/v1", "title": "Juvenile Xanthogranuloma in a Child: A Case Report", "content_text": "Posted on Research Square on 27 October 2026; not peer reviewed; matched Cobimetinib, MRI and Capmatinib.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "Research Square", "doi": "10.21203/rs.3.rs-11133121/v1", "records": [ { "id": "cobimetinib", "kind": "drug", "name": "Cobimetinib", "url": "https://onco.cc/drugs/cobimetinib/" }, { "id": "mri", "kind": "technology", "name": "MRI", "url": "https://onco.cc/technologies/mri/" }, { "id": "capmatinib", "kind": "drug", "name": "Capmatinib", "url": "https://onco.cc/drugs/capmatinib/" }, { "id": "cd163", "kind": "target", "name": "CD163", "url": "https://onco.cc/targets/cd163/" } ] } }, { "id": "https://doi.org/10.64898/2026.10.23.761341#onco-edge-preprint", "url": "https://doi.org/10.64898/2026.10.23.761341", "title": "Lymphoma response to chimeric antigen receptor T cell therapy is driven by endogenous tumor-reactive CD8⁺ T cells", "content_text": "Posted on bioRxiv on 27 October 2026; not peer reviewed; matched CAR-T cell therapy, CD19 and CD58.", "date_published": "2026-10-27T00:00:00Z", "tags": [ "preprint" ], "_onco": { "kind": "preprint", "date": "2026-10-27", "precision": "day", "venue": "bioRxiv", "doi": "10.64898/2026.10.23.761341", "records": [ { "id": "car-t", "kind": "technology", "name": "CAR-T cell therapy", "url": "https://onco.cc/technologies/car-t/" }, { "id": "cd19", "kind": "target", "name": "CD19", "url": "https://onco.cc/targets/cd19/" }, { "id": "cd58", "kind": "target", "name": "CD58", "url": "https://onco.cc/targets/cd58/" }, { "id": "cd8", "kind": "target", "name": "CD8", "url": "https://onco.cc/targets/cd8/" } ] } }, { "id": "https://doi.org/10.1002/ijc.70742#onco-edge-paper", "url": "https://doi.org/10.1002/ijc.70742", "title": "Activity of Low Dose Nivolumab in Patients With Advanced Squamous Cell Carcinomas and Other Cancers.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched Immune checkpoint inhibitors, PD-1 and Nivolumab.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1002/ijc.70742", "records": [ { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" }, { "id": "pd1", "kind": "target", "name": "PD-1", "url": "https://onco.cc/targets/pd1/" }, { "id": "nivolumab", "kind": "drug", "name": "Nivolumab", "url": "https://onco.cc/drugs/nivolumab/" } ] } }, { "id": "https://doi.org/10.1016/j.cels.2026.101757#onco-edge-paper", "url": "https://doi.org/10.1016/j.cels.2026.101757", "title": "Asymmetric crosstalk between the BMP and TGF-β pathways resolves signaling ambiguity.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched Mathematical models of cancer.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1016/j.cels.2026.101757", "records": [ { "id": "mathematical-oncology", "kind": "technology", "name": "Mathematical models of cancer", "url": "https://onco.cc/technologies/mathematical-oncology/" } ] } }, { "id": "https://doi.org/10.3390/jcm15208146#onco-edge-paper", "url": "https://doi.org/10.3390/jcm15208146", "title": "External Validation of MRI-Based Prostate Cancer Risk Calculators in a Contemporary Pre-Biopsy mpMRI Cohort.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched Multiparametric prostate MRI and MRI.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.3390/jcm15208146", "records": [ { "id": "mp-mri", "kind": "technology", "name": "Multiparametric prostate MRI", "url": "https://onco.cc/technologies/mp-mri/" }, { "id": "mri", "kind": "technology", "name": "MRI", "url": "https://onco.cc/technologies/mri/" } ] } }, { "id": "https://doi.org/10.1186/s12985-026-03334-8#onco-edge-paper", "url": "https://doi.org/10.1186/s12985-026-03334-8", "title": "Herpesviruses show consistency in their nuclear egress-associated induction of lamina-depleted areas as measured in an autofluorescent reporter cell model.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched LMNA.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1186/s12985-026-03334-8", "records": [ { "id": "lmna", "kind": "target", "name": "LMNA", "url": "https://onco.cc/targets/lmna/" } ] } }, { "id": "https://doi.org/10.1177/29767342261489476#onco-edge-paper", "url": "https://doi.org/10.1177/29767342261489476", "title": "Impact of Opt-Out Versus Opt-In Recruitment on Engagement of FDNY WTC-Exposed Responders in a Tobacco Cessation Intervention.", "content_text": "Published in Subst Use Addctn J on 20 October 2026; found by the roadmap watch for OPT-IN.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "venue": "Subst Use Addctn J", "doi": "10.1177/29767342261489476", "records": [ { "id": "opt-in", "kind": "trial", "name": "OPT-IN", "url": "https://onco.cc/trials/opt-in/" }, { "id": "gallbladder-cancer-roadmap", "kind": "roadmap", "name": "Gallbladder cancer roadmap: from a chance finding at gallstone surgery to a disease with its own trials", "url": "https://onco.cc/roadmaps/gallbladder-cancer-roadmap/" } ] } }, { "id": "https://doi.org/10.1152/ajpcell.00313.2026#onco-edge-paper", "url": "https://doi.org/10.1152/ajpcell.00313.2026", "title": "Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched PAX7.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1152/ajpcell.00313.2026", "records": [ { "id": "pax7", "kind": "target", "name": "PAX7", "url": "https://onco.cc/targets/pax7/" } ] } }, { "id": "https://doi.org/10.1016/j.canlet.2026.218910#onco-edge-paper", "url": "https://doi.org/10.1016/j.canlet.2026.218910", "title": "LRH-1 is a novel regulator of neutrophil-driven immune responses within the tumor microenvironment.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched NR5A2 and CD4.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1016/j.canlet.2026.218910", "records": [ { "id": "nr5a2", "kind": "target", "name": "NR5A2", "url": "https://onco.cc/targets/nr5a2/" }, { "id": "cd4", "kind": "target", "name": "CD4", "url": "https://onco.cc/targets/cd4/" } ] } }, { "id": "https://doi.org/10.1038/s41746-026-03267-0#onco-edge-paper", "url": "https://doi.org/10.1038/s41746-026-03267-0", "title": "MEDA-PKD: a dynamic, real-time analytics platform for precision care in autosomal dominant polycystic kidney disease.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched Proteomics & phosphoproteomics and EGFR.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1038/s41746-026-03267-0", "records": [ { "id": "proteomics", "kind": "technology", "name": "Proteomics & phosphoproteomics", "url": "https://onco.cc/technologies/proteomics/" }, { "id": "egfr", "kind": "target", "name": "EGFR", "url": "https://onco.cc/targets/egfr/" } ] } }, { "id": "https://doi.org/10.1007/s12032-026-03448-7#onco-edge-paper", "url": "https://doi.org/10.1007/s12032-026-03448-7", "title": "MG53 suppresses the progression of bladder cancer through E3 ubiquitin ligase-mediated degradation of AMPKα.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched BCL-2 and BAX.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1007/s12032-026-03448-7", "records": [ { "id": "bcl2", "kind": "target", "name": "BCL-2", "url": "https://onco.cc/targets/bcl2/" }, { "id": "bax", "kind": "target", "name": "BAX", "url": "https://onco.cc/targets/bax/" } ] } }, { "id": "https://doi.org/10.1371/journal.ppat.1014618#onco-edge-paper", "url": "https://doi.org/10.1371/journal.ppat.1014618", "title": "Selective persistence of HIV-1-infected T cell clones can occur through immune reprogramming driven by defective, transcriptionally active proviruses.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched STAT5, BACH2 and CD4.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1371/journal.ppat.1014618", "records": [ { "id": "stat5", "kind": "target", "name": "STAT5", "url": "https://onco.cc/targets/stat5/" }, { "id": "bach2", "kind": "target", "name": "BACH2", "url": "https://onco.cc/targets/bach2/" }, { "id": "cd4", "kind": "target", "name": "CD4", "url": "https://onco.cc/targets/cd4/" } ] } }, { "id": "https://doi.org/10.1073/pnas.2531364123#onco-edge-paper", "url": "https://doi.org/10.1073/pnas.2531364123", "title": "Transient ATM inhibition enhances knock-in efficiency in hematopoietic stem cells by attenuating the DNA damage response.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched Whole-exome & whole-genome sequencing and ATM.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1073/pnas.2531364123", "records": [ { "id": "wes-wgs", "kind": "technology", "name": "Whole-exome & whole-genome sequencing", "url": "https://onco.cc/technologies/wes-wgs/" }, { "id": "atm", "kind": "target", "name": "ATM", "url": "https://onco.cc/targets/atm/" } ] } }, { "id": "https://doi.org/10.1242/dev.205304#onco-edge-paper", "url": "https://doi.org/10.1242/dev.205304", "title": "Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche.", "content_text": "Published on 20 October 2026 after first appearing as a preprint; matched Mesenchymal stromal cells for tissue damage.", "date_published": "2026-10-20T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-20", "precision": "day", "doi": "10.1242/dev.205304", "records": [ { "id": "rejuv-frontier-mesenchymal-stromal-cells", "kind": "technology", "name": "Mesenchymal stromal cells for tissue damage", "url": "https://onco.cc/technologies/rejuv-frontier-mesenchymal-stromal-cells/" } ] } }, { "id": "https://doi.org/10.1038/s41571-026-01216-0#onco-edge-paper", "url": "https://doi.org/10.1038/s41571-026-01216-0", "title": "An imprecise label in the era of precision medicine: labelling and access for daraxonrasib, the first pan-RAS inhibitor approval.", "content_text": "Published in Nat Rev Clin Oncol on 13 October 2026; matched the OnCo record for Daraxonrasib.", "date_published": "2026-10-13T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-13", "precision": "day", "venue": "Nat Rev Clin Oncol", "doi": "10.1038/s41571-026-01216-0", "records": [ { "id": "daraxonrasib", "kind": "drug", "name": "Daraxonrasib", "url": "https://onco.cc/drugs/daraxonrasib/" } ] } }, { "id": "https://doi.org/10.1182/blood.2026034923#onco-edge-paper", "url": "https://doi.org/10.1182/blood.2026034923", "title": "Germline DDX41 defines a distinct subgroup in MDS undergoing transplantation with reduced relapse and improved survival.", "content_text": "Published in Blood on 13 October 2026; matched the OnCo record for DDX41.", "date_published": "2026-10-13T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-13", "precision": "day", "venue": "Blood", "doi": "10.1182/blood.2026034923", "records": [ { "id": "ddx41", "kind": "target", "name": "DDX41", "url": "https://onco.cc/targets/ddx41/" } ] } }, { "id": "https://doi.org/10.1182/blood.2025030377#onco-edge-paper", "url": "https://doi.org/10.1182/blood.2025030377", "title": "Molecular Consequences and Targeting of PPM1D Overexpression in Myeloproliferative Neoplasms.", "content_text": "Published in Blood on 13 October 2026; matched the OnCo record for PPM1D.", "date_published": "2026-10-13T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-13", "precision": "day", "venue": "Blood", "doi": "10.1182/blood.2025030377", "records": [ { "id": "ppm1d", "kind": "target", "name": "PPM1D", "url": "https://onco.cc/targets/ppm1d/" } ] } }, { "id": "https://doi.org/10.1200/jco-26-00992#onco-edge-paper", "url": "https://doi.org/10.1200/jco-26-00992", "title": "VERIFY: A Phase III Trial of Rusfertide Versus Placebo in Phlebotomy-Dependent Patients With Polycythemia Vera Receiving Standard-of-Care Therapy.", "content_text": "Published in J Clin Oncol on 13 October 2026; matched the OnCo record for Rusfertide.", "date_published": "2026-10-13T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-13", "precision": "day", "venue": "J Clin Oncol", "doi": "10.1200/jco-26-00992", "records": [ { "id": "rusfertide", "kind": "drug", "name": "Rusfertide", "url": "https://onco.cc/drugs/rusfertide/" } ] } }, { "id": "https://doi.org/10.1038/s41388-026-04019-w#onco-edge-paper", "url": "https://doi.org/10.1038/s41388-026-04019-w", "title": "Activation of the endocytosis pathway stratifies subtypes and therapeutic sensitivity in colorectal cancer.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched EGFR.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1038/s41388-026-04019-w", "records": [ { "id": "egfr", "kind": "target", "name": "EGFR", "url": "https://onco.cc/targets/egfr/" } ] } }, { "id": "https://doi.org/10.1111/joa.70256#onco-edge-paper", "url": "https://doi.org/10.1111/joa.70256", "title": "Aging-related morphological changes in the obturator internus and levator ani.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched MRI.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1111/joa.70256", "records": [ { "id": "mri", "kind": "technology", "name": "MRI", "url": "https://onco.cc/technologies/mri/" } ] } }, { "id": "https://doi.org/10.1093/jnci/djag327#onco-edge-paper", "url": "https://doi.org/10.1093/jnci/djag327", "title": "Claims-based frailty, dual eligibility, and potential unmet home-health needs in older breast cancer survivors.", "content_text": "Published in J Natl Cancer Inst on 19 October 2026; matched the OnCo record for CREB3L1.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "venue": "J Natl Cancer Inst", "doi": "10.1093/jnci/djag327", "records": [ { "id": "creb3l1", "kind": "target", "name": "CREB3L1", "url": "https://onco.cc/targets/creb3l1/" }, { "id": "rejuv-age-frailty-and-late-effects", "kind": "technology", "name": "Frailty and late effects in survivors", "url": "https://onco.cc/technologies/rejuv-age-frailty-and-late-effects/" } ] } }, { "id": "https://doi.org/10.1007/s00520-026-11340-3#onco-edge-paper", "url": "https://doi.org/10.1007/s00520-026-11340-3", "title": "Delayed and selective bone health assessment following cancer diagnosis: a real-world gap in survivorship care.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched Immune checkpoint inhibitors, MET and ELL.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1007/s00520-026-11340-3", "records": [ { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" }, { "id": "met", "kind": "target", "name": "MET", "url": "https://onco.cc/targets/met/" }, { "id": "ell", "kind": "target", "name": "ELL", "url": "https://onco.cc/targets/ell/" } ] } }, { "id": "https://doi.org/10.3390/diseases14100384#onco-edge-paper", "url": "https://doi.org/10.3390/diseases14100384", "title": "Divergent Human Papillomavirus Genotype Spectra in Three Indigenous Communities of Venezuela: Implications for Vaccine Choice and Cervical Screening.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched HPV & HBV vaccination, Cxbladder and PSMB6.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.3390/diseases14100384", "records": [ { "id": "hpv-vaccine", "kind": "technology", "name": "HPV & HBV vaccination", "url": "https://onco.cc/technologies/hpv-vaccine/" }, { "id": "cxbladder", "kind": "drug", "name": "Cxbladder", "url": "https://onco.cc/drugs/cxbladder/" }, { "id": "psmb6", "kind": "target", "name": "PSMB6", "url": "https://onco.cc/targets/psmb6/" } ] } }, { "id": "https://doi.org/10.1073/pnas.2611959123#onco-edge-paper", "url": "https://doi.org/10.1073/pnas.2611959123", "title": "Identification and characterization of neoplastic cells in keratin-positive giant cell-rich tumors.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Single-cell & spatial profiling and Spatial transcriptomics.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1073/pnas.2611959123", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "spatial-transcriptomics", "kind": "technology", "name": "Spatial transcriptomics", "url": "https://onco.cc/technologies/spatial-transcriptomics/" }, { "id": "csf1r", "kind": "target", "name": "CSF1R", "url": "https://onco.cc/targets/csf1r/" }, { "id": "csf1", "kind": "target", "name": "CSF1", "url": "https://onco.cc/targets/csf1/" }, { "id": "ncor2", "kind": "target", "name": "NCOR2", "url": "https://onco.cc/targets/ncor2/" } ] } }, { "id": "https://doi.org/10.1158/1055-9965.epi-26-0120#onco-edge-paper", "url": "https://doi.org/10.1158/1055-9965.epi-26-0120", "title": "Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched Oligonucleotide therapeutics, PSMB8 and NFE2L2.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1158/1055-9965.epi-26-0120", "records": [ { "id": "antisense-sirna", "kind": "technology", "name": "Oligonucleotide therapeutics", "url": "https://onco.cc/technologies/antisense-sirna/" }, { "id": "psmb8", "kind": "target", "name": "PSMB8", "url": "https://onco.cc/targets/psmb8/" }, { "id": "nfe2l2", "kind": "target", "name": "NFE2L2", "url": "https://onco.cc/targets/nfe2l2/" }, { "id": "clcn6", "kind": "target", "name": "CLCN6", "url": "https://onco.cc/targets/clcn6/" } ] } }, { "id": "https://doi.org/10.3390/cancers18203374#onco-edge-paper", "url": "https://doi.org/10.3390/cancers18203374", "title": "Longitudinal Flow Cytometric Profiling of CAR-T and Endogenous T Cells Following CD19 CAR-T Therapy.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched Tisagenlecleucel, CAR-T cell therapy and CD19.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.3390/cancers18203374", "records": [ { "id": "tisagenlecleucel", "kind": "drug", "name": "Tisagenlecleucel", "url": "https://onco.cc/drugs/tisagenlecleucel/" }, { "id": "car-t", "kind": "technology", "name": "CAR-T cell therapy", "url": "https://onco.cc/technologies/car-t/" }, { "id": "cd19", "kind": "target", "name": "CD19", "url": "https://onco.cc/targets/cd19/" }, { "id": "pd1", "kind": "target", "name": "PD-1", "url": "https://onco.cc/targets/pd1/" }, { "id": "tigit", "kind": "target", "name": "TIGIT", "url": "https://onco.cc/targets/tigit/" }, { "id": "rejuv-tx-icans-and-neurocognition", "kind": "technology", "name": "ICANS, and whether thinking recovers after CAR-T", "url": "https://onco.cc/technologies/rejuv-tx-icans-and-neurocognition/" } ] } }, { "id": "https://doi.org/10.3390/arm94050075#onco-edge-paper", "url": "https://doi.org/10.3390/arm94050075", "title": "Opportunistic Cardiovascular Assessment During Lung Cancer Screening with Low-Dose Computed Tomography: A New Window for Prevention.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched CT and AI in radiology.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.3390/arm94050075", "records": [ { "id": "ct", "kind": "technology", "name": "CT", "url": "https://onco.cc/technologies/ct/" }, { "id": "radiology-ai-screening", "kind": "technology", "name": "AI in radiology", "url": "https://onco.cc/technologies/radiology-ai-screening/" } ] } }, { "id": "https://doi.org/10.1097/coc.0000000000001390#onco-edge-paper", "url": "https://doi.org/10.1097/coc.0000000000001390", "title": "Sex Differences in Postoperative Outcomes for Men and Women With Colon Cancer in the US Military Health System.", "content_text": "Published in Am J Clin Oncol on 19 October 2026; matched the OnCo record for Localised anal squamous cell carcinoma.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "venue": "Am J Clin Oncol", "doi": "10.1097/coc.0000000000001390", "records": [ { "id": "localised-anal-cancer", "kind": "cancer", "name": "Localised anal squamous cell carcinoma", "url": "https://onco.cc/cancers/localised-anal-cancer/" } ] } }, { "id": "https://doi.org/10.1038/s44321-026-00542-1#onco-edge-paper", "url": "https://doi.org/10.1038/s44321-026-00542-1", "title": "Spatial polarization of endothelial ICAM-1 governs T-cell exclusion in melanoma.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling, Immune checkpoint inhibitors and PD-1.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1038/s44321-026-00542-1", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" }, { "id": "pd1", "kind": "target", "name": "PD-1", "url": "https://onco.cc/targets/pd1/" } ] } }, { "id": "https://doi.org/10.4103/aam.aam_391_25#onco-edge-paper", "url": "https://doi.org/10.4103/aam.aam_391_25", "title": "Talquetamab and Its Effect on Relapsed and Refractory Multiple Myeloma.", "content_text": "Published in Ann Afr Med on 19 October 2026; matched the OnCo record for Talquetamab.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "venue": "Ann Afr Med", "doi": "10.4103/aam.aam_391_25", "records": [ { "id": "talquetamab", "kind": "drug", "name": "Talquetamab", "url": "https://onco.cc/drugs/talquetamab/" } ] } }, { "id": "https://doi.org/10.1186/s12947-026-00388-0#onco-edge-paper", "url": "https://doi.org/10.1186/s12947-026-00388-0", "title": "Time-aligned segmental strain as a diagnostic marker for obstructive coronary artery disease in patients with chronic chest pain.", "content_text": "Published on 19 October 2026 after first appearing as a preprint; matched CT and Strain echocardiography.", "date_published": "2026-10-19T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-19", "precision": "day", "doi": "10.1186/s12947-026-00388-0", "records": [ { "id": "ct", "kind": "technology", "name": "CT", "url": "https://onco.cc/technologies/ct/" }, { "id": "strain-echocardiography-gls", "kind": "technology", "name": "Strain echocardiography", "url": "https://onco.cc/technologies/strain-echocardiography-gls/" } ] } }, { "id": "https://doi.org/10.1002/advs.78350#onco-edge-paper", "url": "https://doi.org/10.1002/advs.78350", "title": "Acinar-Derived Organoids Reveal Stage-Specific Control of Acinar Plasticity.", "content_text": "Published in Adv Sci (Weinh) on 18 October 2026; matched the OnCo record for IGF-1 receptor.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Adv Sci (Weinh)", "doi": "10.1002/advs.78350", "records": [ { "id": "igf1r", "kind": "target", "name": "IGF-1 receptor", "url": "https://onco.cc/targets/igf1r/" } ] } }, { "id": "https://doi.org/10.1007/s11523-026-01260-x#onco-edge-paper", "url": "https://doi.org/10.1007/s11523-026-01260-x", "title": "Adjuvant Systemic Therapies After Nephrectomy for Renal Cell Carcinoma: A Bayesian Network Meta-Analysis and Multi-Criteria Benefit-Risk Assessment.", "content_text": "Published in Target Oncol on 18 October 2026; matched the OnCo record for Belzutifan.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Target Oncol", "doi": "10.1007/s11523-026-01260-x", "records": [ { "id": "belzutifan", "kind": "drug", "name": "Belzutifan", "url": "https://onco.cc/drugs/belzutifan/" } ] } }, { "id": "https://doi.org/10.1002/pros.70268#onco-edge-paper", "url": "https://doi.org/10.1002/pros.70268", "title": "Age Does Not Independently Predict Biochemical Recurrence in Prostate Cancer Following Radical Prostatectomy: A Comparative Analysis of 4223 pT2N0R0 Patients.", "content_text": "Published in Prostate on 18 October 2026; matched the OnCo record for Localised penile cancer.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Prostate", "doi": "10.1002/pros.70268", "records": [ { "id": "localised-penile-cancer", "kind": "cancer", "name": "Localised penile cancer", "url": "https://onco.cc/cancers/localised-penile-cancer/" }, { "id": "prostate-bcr", "kind": "cancer", "name": "Biochemical recurrence of prostate cancer", "url": "https://onco.cc/cancers/prostate-bcr/" } ] } }, { "id": "https://doi.org/10.12659/ajcr.953248#onco-edge-paper", "url": "https://doi.org/10.12659/ajcr.953248", "title": "An Integrated Approach to MSI-High Colorectal Cancer Therapy in a Young Patient: A Clinical Case.", "content_text": "Published in Am J Case Rep on 18 October 2026; matched the OnCo record for FOLFOX.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Am J Case Rep", "doi": "10.12659/ajcr.953248", "records": [ { "id": "folfox", "kind": "drug", "name": "FOLFOX", "url": "https://onco.cc/drugs/folfox/" } ] } }, { "id": "https://doi.org/10.3390/audiolres16050159#onco-edge-paper", "url": "https://doi.org/10.3390/audiolres16050159", "title": "Autoimmune Inner Ear Disease: The Current State of Knowledge.", "content_text": "Published on 18 October 2026 after first appearing as a preprint; matched State.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "doi": "10.3390/audiolres16050159", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.1111/his.70303#onco-edge-paper", "url": "https://doi.org/10.1111/his.70303", "title": "Characterization of the morphological, immunophenotypical and cytogenetic features of high-grade B-cell lymphoma with 11q aberration.", "content_text": "Published in Histopathology on 18 October 2026; matched the OnCo record for Burkitt lymphoma.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Histopathology", "doi": "10.1111/his.70303", "records": [ { "id": "burkitt-lymphoma", "kind": "cancer", "name": "Burkitt lymphoma", "url": "https://onco.cc/cancers/burkitt-lymphoma/" }, { "id": "ddx3x", "kind": "target", "name": "DDX3X", "url": "https://onco.cc/targets/ddx3x/" } ] } }, { "id": "https://doi.org/10.3390/ijms27209257#onco-edge-paper", "url": "https://doi.org/10.3390/ijms27209257", "title": "Circulating α-Klotho Is Elevated in Breast Cancer and Positively Correlates with IGF-1.", "content_text": "Published on 18 October 2026 after first appearing as a preprint; matched HER2, Estrogen receptor and Progesterone receptor.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "doi": "10.3390/ijms27209257", "records": [ { "id": "her2", "kind": "target", "name": "HER2", "url": "https://onco.cc/targets/her2/" }, { "id": "estrogen-receptor", "kind": "target", "name": "Estrogen receptor", "url": "https://onco.cc/targets/estrogen-receptor/" }, { "id": "pgr", "kind": "target", "name": "Progesterone receptor", "url": "https://onco.cc/targets/pgr/" } ] } }, { "id": "https://doi.org/10.1016/j.urolonc.2026.09.012#onco-edge-paper", "url": "https://doi.org/10.1016/j.urolonc.2026.09.012", "title": "Comparison of cardiovascular events in patients with metastatic hormone sensitive prostate cancer treated with LHRH agonists to LHRH antagonists in the US: A retrospective cohort study.", "content_text": "Published in Urol Oncol on 18 October 2026; matched the OnCo record for Degarelix.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Urol Oncol", "doi": "10.1016/j.urolonc.2026.09.012", "records": [ { "id": "degarelix", "kind": "drug", "name": "Degarelix", "url": "https://onco.cc/drugs/degarelix/" }, { "id": "prostate-mhspc", "kind": "cancer", "name": "Metastatic hormone-sensitive prostate cancer", "url": "https://onco.cc/cancers/prostate-mhspc/" }, { "id": "relugolix", "kind": "drug", "name": "Relugolix", "url": "https://onco.cc/drugs/relugolix/" }, { "id": "triptorelin", "kind": "drug", "name": "Triptorelin", "url": "https://onco.cc/drugs/triptorelin/" } ] } }, { "id": "https://doi.org/10.1002/advs.78135#onco-edge-paper", "url": "https://doi.org/10.1002/advs.78135", "title": "Foundation Model-Enabled Pathology-Informed MRI Model for Preoperative Prediction of Vessels Encapsulating Tumor Clusters in Resectable Hepatocellular Carcinoma: A Multicenter Retrospective Study.", "content_text": "Published in Adv Sci (Weinh) on 18 October 2026; matched the OnCo record for Pathology & radiology foundation models.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Adv Sci (Weinh)", "doi": "10.1002/advs.78135", "records": [ { "id": "pathology-foundation-model", "kind": "technology", "name": "Pathology & radiology foundation models", "url": "https://onco.cc/technologies/pathology-foundation-model/" } ] } }, { "id": "https://doi.org/10.1177/09564624261495346#onco-edge-paper", "url": "https://doi.org/10.1177/09564624261495346", "title": "HIV-1 diagnosis during pre-exposure prophylaxis: A case report.", "content_text": "Published in Int J STD AIDS on 18 October 2026; matched the OnCo record for Follicular thyroid cancer.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Int J STD AIDS", "doi": "10.1177/09564624261495346", "records": [ { "id": "follicular-thyroid-cancer", "kind": "cancer", "name": "Follicular thyroid cancer", "url": "https://onco.cc/cancers/follicular-thyroid-cancer/" } ] } }, { "id": "https://doi.org/10.3390/ph19101639#onco-edge-paper", "url": "https://doi.org/10.3390/ph19101639", "title": "MDL-001: An Oral, Direct-Acting Broad-Spectrum Antiviral for Influenza-like Illness (ILI) and Chronic Hepatitis In Vivo.", "content_text": "Published on 18 October 2026 after first appearing as a preprint; matched Pertuzumab, Azacitidine and Decitabine + cedazuridine.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "doi": "10.3390/ph19101639", "records": [ { "id": "pertuzumab", "kind": "drug", "name": "Pertuzumab", "url": "https://onco.cc/drugs/pertuzumab/" }, { "id": "azacitidine", "kind": "drug", "name": "Azacitidine", "url": "https://onco.cc/drugs/azacitidine/" }, { "id": "decitabine-cedazuridine", "kind": "drug", "name": "Decitabine + cedazuridine", "url": "https://onco.cc/drugs/decitabine-cedazuridine/" } ] } }, { "id": "https://doi.org/10.1002/smll.76209#onco-edge-paper", "url": "https://doi.org/10.1002/smll.76209", "title": "Multifunctional Magneto‑Thermal Probe Enhances the Efficacy of Tumor Therapy as a Tumor Nanovaccine.", "content_text": "Published in Small on 18 October 2026; matched the OnCo record for TIL therapy.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Small", "doi": "10.1002/smll.76209", "records": [ { "id": "til-therapy", "kind": "technology", "name": "TIL therapy", "url": "https://onco.cc/technologies/til-therapy/" } ] } }, { "id": "https://doi.org/10.3390/jcm15208084#onco-edge-paper", "url": "https://doi.org/10.3390/jcm15208084", "title": "Perioperative Hemoglobin Decline After Deep Endometriosis Surgery: Association with Surgery Duration and Exploratory Analyses of Operative Extent.", "content_text": "Published on 18 October 2026 after first appearing as a preprint; matched MET.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "doi": "10.3390/jcm15208084", "records": [ { "id": "met", "kind": "target", "name": "MET", "url": "https://onco.cc/targets/met/" } ] } }, { "id": "https://doi.org/10.1111/cup.70239#onco-edge-paper", "url": "https://doi.org/10.1111/cup.70239", "title": "PRAME Immunohistochemistry and Molecular Profiling in Undifferentiated Cutaneous Pleomorphic Neoplasms: A Case Series of 8 Tumors.", "content_text": "Published in J Cutan Pathol on 18 October 2026; matched the OnCo record for PRAME.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "J Cutan Pathol", "doi": "10.1111/cup.70239", "records": [ { "id": "prame", "kind": "target", "name": "PRAME", "url": "https://onco.cc/targets/prame/" } ] } }, { "id": "https://doi.org/10.1080/14786419.2026.2749088#onco-edge-paper", "url": "https://doi.org/10.1080/14786419.2026.2749088", "title": "Structural characterisation and anti-hepatoma activities of an acidic polysaccharide extracted from Morinda citrifolia L. (Noni) fruits.", "content_text": "Published in Nat Prod Res on 18 October 2026; matched the OnCo record for CASP8.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Nat Prod Res", "doi": "10.1080/14786419.2026.2749088", "records": [ { "id": "casp8", "kind": "target", "name": "CASP8", "url": "https://onco.cc/targets/casp8/" } ] } }, { "id": "https://doi.org/10.1111/bjh.70909#onco-edge-paper", "url": "https://doi.org/10.1111/bjh.70909", "title": "Subtype- and functional class-dependent prognostic impact of CSF3R mutations in acute myeloid leukaemia: A cohort study of 2500 patients.", "content_text": "Published in Br J Haematol on 18 October 2026; matched the OnCo record for Acute promyelocytic leukaemia.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Br J Haematol", "doi": "10.1111/bjh.70909", "records": [ { "id": "apl", "kind": "cancer", "name": "Acute promyelocytic leukaemia", "url": "https://onco.cc/cancers/apl/" }, { "id": "cebpa", "kind": "target", "name": "CEBPA", "url": "https://onco.cc/targets/cebpa/" }, { "id": "csf3r", "kind": "target", "name": "G-CSF receptor", "url": "https://onco.cc/targets/csf3r/" }, { "id": "pleural-mesothelioma", "kind": "cancer", "name": "Pleural mesothelioma", "url": "https://onco.cc/cancers/pleural-mesothelioma/" }, { "id": "runx1t1", "kind": "target", "name": "RUNX1T1", "url": "https://onco.cc/targets/runx1t1/" } ] } }, { "id": "https://doi.org/10.1002/advs.78304#onco-edge-paper", "url": "https://doi.org/10.1002/advs.78304", "title": "Thioredoxin-2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation.", "content_text": "Published in Adv Sci (Weinh) on 18 October 2026; matched the OnCo record for KMT2B.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Adv Sci (Weinh)", "doi": "10.1002/advs.78304", "records": [ { "id": "kmt2b", "kind": "target", "name": "KMT2B", "url": "https://onco.cc/targets/kmt2b/" } ] } }, { "id": "https://doi.org/10.1002/advs.78310#onco-edge-paper", "url": "https://doi.org/10.1002/advs.78310", "title": "Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55-ESCRT-Associated Vesicular Damage Clearance.", "content_text": "Published in Adv Sci (Weinh) on 18 October 2026; matched the OnCo record for PLK1.", "date_published": "2026-10-18T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-18", "precision": "day", "venue": "Adv Sci (Weinh)", "doi": "10.1002/advs.78310", "records": [ { "id": "plk1", "kind": "target", "name": "PLK1", "url": "https://onco.cc/targets/plk1/" } ] } }, { "id": "https://doi.org/10.1016/j.canlet.2026.218900#onco-edge-paper", "url": "https://doi.org/10.1016/j.canlet.2026.218900", "title": "2-Hydroxyisobutyrylation of SRSF9 Regulates CD44 Alternative Splicing to Promote Colorectal Cancer Liver Metastasis.", "content_text": "Published in Cancer Lett on 17 October 2026; matched the OnCo record for KAT7.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Cancer Lett", "doi": "10.1016/j.canlet.2026.218900", "records": [ { "id": "kat7", "kind": "target", "name": "KAT7", "url": "https://onco.cc/targets/kat7/" }, { "id": "rrm1", "kind": "target", "name": "Ribonucleotide reductase", "url": "https://onco.cc/targets/rrm1/" } ] } }, { "id": "https://doi.org/10.1016/j.mbs.2026.109826#onco-edge-paper", "url": "https://doi.org/10.1016/j.mbs.2026.109826", "title": "A degenerate Fokker-Planck stochastic modeling and simulation of the signaling pathways in esophageal cancer.", "content_text": "Published in Math Biosci on 17 October 2026; matched the OnCo record for Appendiceal cancer and pseudomyxoma peritonei.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Math Biosci", "doi": "10.1016/j.mbs.2026.109826", "records": [ { "id": "appendiceal", "kind": "cancer", "name": "Appendiceal cancer and pseudomyxoma peritonei", "url": "https://onco.cc/cancers/appendiceal/" }, { "id": "low-grade-appendiceal-mucinous-neoplasm", "kind": "cancer", "name": "Low-grade appendiceal mucinous neoplasm and pseudomyxoma peritonei", "url": "https://onco.cc/cancers/low-grade-appendiceal-mucinous-neoplasm/" } ] } }, { "id": "https://doi.org/10.1007/s00439-026-02887-6#onco-edge-paper", "url": "https://doi.org/10.1007/s00439-026-02887-6", "title": "A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals.", "content_text": "Published in Hum Genet on 17 October 2026; matched the OnCo record for FAT1.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Hum Genet", "doi": "10.1007/s00439-026-02887-6", "records": [ { "id": "fat1", "kind": "target", "name": "FAT1", "url": "https://onco.cc/targets/fat1/" }, { "id": "setbp1", "kind": "target", "name": "SETBP1", "url": "https://onco.cc/targets/setbp1/" }, { "id": "steap1", "kind": "target", "name": "STEAP1", "url": "https://onco.cc/targets/steap1/" } ] } }, { "id": "https://doi.org/10.1016/j.jpainsymman.2026.10.014#onco-edge-paper", "url": "https://doi.org/10.1016/j.jpainsymman.2026.10.014", "title": "Acupuncture versus reflexology for cancer-related pain in palliative care: a pragmatic study.", "content_text": "Published in J Pain Symptom Manage on 17 October 2026; matched the OnCo record for Reflexology.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "J Pain Symptom Manage", "doi": "10.1016/j.jpainsymman.2026.10.014", "records": [ { "id": "reflexology-cancer", "kind": "technology", "name": "Reflexology", "url": "https://onco.cc/technologies/reflexology-cancer/" } ] } }, { "id": "https://doi.org/10.1016/j.bbrep.2026.102845#onco-edge-paper", "url": "https://doi.org/10.1016/j.bbrep.2026.102845", "title": "Addressing complex autofluorescence signatures in solid tissue samples to enhance full spectrum flow cytometry of non-immune cells.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling and CCDC6.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.1016/j.bbrep.2026.102845", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" }, { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" } ] } }, { "id": "https://doi.org/10.1016/j.isci.2026.117950#onco-edge-paper", "url": "https://doi.org/10.1016/j.isci.2026.117950", "title": "Alteration of empathy-related behaviors in two strains of mice expressing mutations of the α5 cholinergic nicotinic receptor subunit.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched State and CHRNA5.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.1016/j.isci.2026.117950", "records": [ { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" }, { "id": "chrna5", "kind": "target", "name": "CHRNA5", "url": "https://onco.cc/targets/chrna5/" } ] } }, { "id": "https://doi.org/10.7759/cureus.118052#onco-edge-paper", "url": "https://doi.org/10.7759/cureus.118052", "title": "Anti-N-Methyl-D-Aspartate Receptor Encephalitis With Autonomic Instability and Focal Seizures Without Detectable Ovarian Teratoma.", "content_text": "Published in Cureus on 17 October 2026; matched the OnCo record for Human normal immunoglobulin.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Cureus", "doi": "10.7759/cureus.118052", "records": [ { "id": "human-normal-immunoglobulin", "kind": "drug", "name": "Human normal immunoglobulin", "url": "https://onco.cc/drugs/human-normal-immunoglobulin/" } ] } }, { "id": "https://doi.org/10.1007/s11523-026-01263-8#onco-edge-paper", "url": "https://doi.org/10.1007/s11523-026-01263-8", "title": "Association of TP53 Truncating Mutations with Time to Treatment Failure after First-Line Chemoimmunotherapy in HER2-Mutant Non-Small Cell Lung Cancer.", "content_text": "Published in Target Oncol on 17 October 2026; matched the OnCo record for HER2-mutant non-small-cell lung cancer.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Target Oncol", "doi": "10.1007/s11523-026-01263-8", "records": [ { "id": "her2-mutant-nsclc", "kind": "cancer", "name": "HER2-mutant non-small-cell lung cancer", "url": "https://onco.cc/cancers/her2-mutant-nsclc/" }, { "id": "pemetrexed", "kind": "drug", "name": "Pemetrexed", "url": "https://onco.cc/drugs/pemetrexed/" } ] } }, { "id": "https://doi.org/10.1002/ccr3.73736#onco-edge-paper", "url": "https://doi.org/10.1002/ccr3.73736", "title": "B-Lymphoblastic Leukemia Presenting as Bilateral Ovarian Masses in a 20-Year-Old Woman.", "content_text": "Published in Clin Case Rep on 17 October 2026; matched the OnCo record for CREBBP.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Clin Case Rep", "doi": "10.1002/ccr3.73736", "records": [ { "id": "crebbp", "kind": "target", "name": "CREBBP", "url": "https://onco.cc/targets/crebbp/" }, { "id": "kmt2d", "kind": "target", "name": "KMT2D", "url": "https://onco.cc/targets/kmt2d/" } ] } }, { "id": "https://doi.org/10.1002/ijc.70765#onco-edge-paper", "url": "https://doi.org/10.1002/ijc.70765", "title": "BRCAness-Driven Prognostic Model and Regimen-Specific Therapeutic Implications in Triple-Negative Breast Cancer With Residual Disease After Neoadjuvant Chemotherapy.", "content_text": "Published in Int J Cancer on 17 October 2026; matched the OnCo record for HRD & BRCA testing.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Int J Cancer", "doi": "10.1002/ijc.70765", "records": [ { "id": "hrd-testing", "kind": "technology", "name": "HRD & BRCA testing", "url": "https://onco.cc/technologies/hrd-testing/" } ] } }, { "id": "https://doi.org/10.1159/ort/aecag005#onco-edge-paper", "url": "https://doi.org/10.1159/ort/aecag005", "title": "Case Report: Dose dependent intracranial response to sotorasib in KRASG12C-mutated lung cancer brain metastases.", "content_text": "Published in Oncol Res Treat on 17 October 2026; matched the OnCo record for Sotorasib.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Oncol Res Treat", "doi": "10.1159/ort/aecag005", "records": [ { "id": "sotorasib", "kind": "drug", "name": "Sotorasib", "url": "https://onco.cc/drugs/sotorasib/" } ] } }, { "id": "https://doi.org/10.3390/biomedicines14102366#onco-edge-paper", "url": "https://doi.org/10.3390/biomedicines14102366", "title": "Computational Analysis of the Homologous Mouse Double RINGs Interface for Targeted Anticancer Drug Design.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched MDM2.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.3390/biomedicines14102366", "records": [ { "id": "mdm2", "kind": "target", "name": "MDM2", "url": "https://onco.cc/targets/mdm2/" } ] } }, { "id": "https://doi.org/10.1016/j.oftale.2026.502668#onco-edge-paper", "url": "https://doi.org/10.1016/j.oftale.2026.502668", "title": "Conjunctival involvement with corneal extension in pediatric mycosis fungoides. Surgical and immunomodulatory management.", "content_text": "Published in Arch Soc Esp Oftalmol (Engl Ed) on 17 October 2026; matched the OnCo record for Mycosis fungoides.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Arch Soc Esp Oftalmol (Engl Ed)", "doi": "10.1016/j.oftale.2026.502668", "records": [ { "id": "mycosis-fungoides", "kind": "cancer", "name": "Mycosis fungoides", "url": "https://onco.cc/cancers/mycosis-fungoides/" } ] } }, { "id": "https://doi.org/10.1016/j.canlet.2026.218898#onco-edge-paper", "url": "https://doi.org/10.1016/j.canlet.2026.218898", "title": "Corrigendum to \"Chinese guidelines for the diagnosis and treatment of Craniopharyngioma in children (2025)\" [Cancer Lett. 659 (2026) 218784].", "content_text": "Published in Cancer Lett on 17 October 2026; matched the OnCo record for Craniopharyngioma.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Cancer Lett", "doi": "10.1016/j.canlet.2026.218898", "records": [ { "id": "craniopharyngioma", "kind": "cancer", "name": "Craniopharyngioma", "url": "https://onco.cc/cancers/craniopharyngioma/" } ] } }, { "id": "https://doi.org/10.1016/j.lfs.2026.124743#onco-edge-paper", "url": "https://doi.org/10.1016/j.lfs.2026.124743", "title": "Dapagliflozin alleviates CYH33-induced hyperglycemia and preserves antitumor immunity against ovarian cancer in type 1 diabetic mice.", "content_text": "Published in Life Sci on 17 October 2026; matched the OnCo record for Clear cell ovarian cancer.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Life Sci", "doi": "10.1016/j.lfs.2026.124743", "records": [ { "id": "clear-cell-ovarian-cancer", "kind": "cancer", "name": "Clear cell ovarian cancer", "url": "https://onco.cc/cancers/clear-cell-ovarian-cancer/" }, { "id": "cyh33", "kind": "drug", "name": "CYH33", "url": "https://onco.cc/drugs/cyh33/" } ] } }, { "id": "https://doi.org/10.1186/s12864-026-13475-3#onco-edge-paper", "url": "https://doi.org/10.1186/s12864-026-13475-3", "title": "Decoding radiation-induced transcriptomic signatures of human leukocytes using long-read RNA-seq: clinical and biodosimetric implications.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and RPS19.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.1186/s12864-026-13475-3", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "rps19", "kind": "target", "name": "RPS19", "url": "https://onco.cc/targets/rps19/" } ] } }, { "id": "https://doi.org/10.1016/j.ad.2026.104769#onco-edge-paper", "url": "https://doi.org/10.1016/j.ad.2026.104769", "title": "Dermoscopy of intraepidermal keratinocytic neoplasms in solid organ transplant recipients: a single-center prospective real-world study supported by machine learning.", "content_text": "Published in Actas Dermosifiliogr on 17 October 2026; matched the OnCo record for Bowen's disease.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Actas Dermosifiliogr", "doi": "10.1016/j.ad.2026.104769", "records": [ { "id": "bowens-disease", "kind": "cancer", "name": "Bowen's disease", "url": "https://onco.cc/cancers/bowens-disease/" }, { "id": "cutaneous-scc", "kind": "cancer", "name": "Cutaneous squamous cell carcinoma", "url": "https://onco.cc/cancers/cutaneous-scc/" } ] } }, { "id": "https://doi.org/10.1002/ccr3.73701#onco-edge-paper", "url": "https://doi.org/10.1002/ccr3.73701", "title": "Diffuse Leptomeningeal Glioneuronal Tumor With Initial Diagnosis of Pilocytic Astrocytoma With Anaplasia: A Case Study.", "content_text": "Published in Clin Case Rep on 17 October 2026; matched the OnCo record for Paediatric low-grade glioma.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Clin Case Rep", "doi": "10.1002/ccr3.73701", "records": [ { "id": "paediatric-low-grade-glioma", "kind": "cancer", "name": "Paediatric low-grade glioma", "url": "https://onco.cc/cancers/paediatric-low-grade-glioma/" } ] } }, { "id": "https://doi.org/10.1080/15592294.2026.2745292#onco-edge-paper", "url": "https://doi.org/10.1080/15592294.2026.2745292", "title": "Diverse patterns of transcriptional regulation and epigenetic reprogramming within PMDs contribute to ESCC progression by regulating EMT and immunosuppression.", "content_text": "Published in Epigenetics on 17 October 2026; matched the OnCo record for TDO2.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Epigenetics", "doi": "10.1080/15592294.2026.2745292", "records": [ { "id": "tdo2", "kind": "target", "name": "TDO2", "url": "https://onco.cc/targets/tdo2/" }, { "id": "tim3", "kind": "target", "name": "TIM-3", "url": "https://onco.cc/targets/tim3/" } ] } }, { "id": "https://doi.org/10.1245/s10434-026-20450-5#onco-edge-paper", "url": "https://doi.org/10.1245/s10434-026-20450-5", "title": "Does Additional Margin Excision During Pegulicianine Fluorescence-Guided Surgery (pFGS) Affect Patient Breast Satisfaction?", "content_text": "Published in Ann Surg Oncol on 17 October 2026; matched the OnCo record for Fluorescence-guided surgery.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Ann Surg Oncol", "doi": "10.1245/s10434-026-20450-5", "records": [ { "id": "fluorescence-guided-surgery", "kind": "technology", "name": "Fluorescence-guided surgery", "url": "https://onco.cc/technologies/fluorescence-guided-surgery/" }, { "id": "pegulicianine", "kind": "drug", "name": "Pegulicianine", "url": "https://onco.cc/drugs/pegulicianine/" } ] } }, { "id": "https://doi.org/10.2478/aite-2026-0025#onco-edge-paper", "url": "https://doi.org/10.2478/aite-2026-0025", "title": "Ectromelia Virus Reprograms the Noncanonical NF-κB Signaling Pathway in HeLa Epithelial Cells.", "content_text": "Published in Arch Immunol Ther Exp (Warsz) on 17 October 2026; matched the OnCo record for BIRC3.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Arch Immunol Ther Exp (Warsz)", "doi": "10.2478/aite-2026-0025", "records": [ { "id": "birc3", "kind": "target", "name": "BIRC3", "url": "https://onco.cc/targets/birc3/" }, { "id": "nfkb2", "kind": "target", "name": "NFKB2", "url": "https://onco.cc/targets/nfkb2/" }, { "id": "psip1", "kind": "target", "name": "PSIP1", "url": "https://onco.cc/targets/psip1/" }, { "id": "snd1", "kind": "target", "name": "SND1", "url": "https://onco.cc/targets/snd1/" }, { "id": "tnfaip3", "kind": "target", "name": "TNFAIP3", "url": "https://onco.cc/targets/tnfaip3/" }, { "id": "traf3", "kind": "target", "name": "TRAF3", "url": "https://onco.cc/targets/traf3/" } ] } }, { "id": "https://doi.org/10.1007/s00520-026-11314-5#onco-edge-paper", "url": "https://doi.org/10.1007/s00520-026-11314-5", "title": "Expert consensus on the management of peripheral neuropathy in patients with lymphoma on brentuximab vedotin.", "content_text": "Published in Support Care Cancer on 17 October 2026; matched the OnCo record for Brentuximab vedotin.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Support Care Cancer", "doi": "10.1007/s00520-026-11314-5", "records": [ { "id": "brentuximab-vedotin", "kind": "drug", "name": "Brentuximab vedotin", "url": "https://onco.cc/drugs/brentuximab-vedotin/" }, { "id": "cd30", "kind": "target", "name": "CD30", "url": "https://onco.cc/targets/cd30/" } ] } }, { "id": "https://doi.org/10.1038/s41408-026-01646-0#onco-edge-paper", "url": "https://doi.org/10.1038/s41408-026-01646-0", "title": "Final analysis results from DREAMM-3, a phase 3 study of belantamab mafodotin versus pomalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma.", "content_text": "Published in Blood Cancer J on 17 October 2026; matched the OnCo record for Belantamab mafodotin.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Blood Cancer J", "doi": "10.1038/s41408-026-01646-0", "records": [ { "id": "belantamab-mafodotin", "kind": "drug", "name": "Belantamab mafodotin", "url": "https://onco.cc/drugs/belantamab-mafodotin/" }, { "id": "pomalidomide", "kind": "drug", "name": "Pomalidomide", "url": "https://onco.cc/drugs/pomalidomide/" } ] } }, { "id": "https://doi.org/10.1007/s40257-026-01080-9#onco-edge-paper", "url": "https://doi.org/10.1007/s40257-026-01080-9", "title": "From MAPK Reactivation to Response: Clinical Approaches Targeting BRAF/MEK Resistance in Melanoma.", "content_text": "Published in Am J Clin Dermatol on 17 October 2026; matched the OnCo record for ARAF.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Am J Clin Dermatol", "doi": "10.1007/s40257-026-01080-9", "records": [ { "id": "araf", "kind": "target", "name": "ARAF", "url": "https://onco.cc/targets/araf/" }, { "id": "braf-v600-melanoma", "kind": "cancer", "name": "BRAF V600-mutant melanoma", "url": "https://onco.cc/cancers/braf-v600-melanoma/" } ] } }, { "id": "https://doi.org/10.1080/14656566.2026.2752126#onco-edge-paper", "url": "https://doi.org/10.1080/14656566.2026.2752126", "title": "Gedatolisib after CDK4/6 inhibition in HR-Positive/HER2-negative advanced breast cancer: pharmacology, phase iii evidence, and therapeutic positioning.", "content_text": "Published in Expert Opin Pharmacother on 17 October 2026; matched the OnCo record for Fulvestrant.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Expert Opin Pharmacother", "doi": "10.1080/14656566.2026.2752126", "records": [ { "id": "fulvestrant", "kind": "drug", "name": "Fulvestrant", "url": "https://onco.cc/drugs/fulvestrant/" }, { "id": "gedatolisib", "kind": "drug", "name": "Gedatolisib", "url": "https://onco.cc/drugs/gedatolisib/" }, { "id": "palbociclib", "kind": "drug", "name": "Palbociclib", "url": "https://onco.cc/drugs/palbociclib/" } ] } }, { "id": "https://doi.org/10.1016/j.clim.2026.110785#onco-edge-paper", "url": "https://doi.org/10.1016/j.clim.2026.110785", "title": "Genetic and clinical evidence supports HLA-DR+ CD8+ T cells as a favorable immune biomarker in acute myeloid leukemia.", "content_text": "Published in Clin Immunol on 17 October 2026; matched the OnCo record for Acute promyelocytic leukaemia.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Clin Immunol", "doi": "10.1016/j.clim.2026.110785", "records": [ { "id": "apl", "kind": "cancer", "name": "Acute promyelocytic leukaemia", "url": "https://onco.cc/cancers/apl/" } ] } }, { "id": "https://doi.org/10.1016/j.bcp.2026.118553#onco-edge-paper", "url": "https://doi.org/10.1016/j.bcp.2026.118553", "title": "Genistein targets Wnt5a to alleviate temporomandibular joint osteoarthritis by suppressing JNK/JUN-dependent MMP9 activation.", "content_text": "Published in Biochem Pharmacol on 17 October 2026; matched the OnCo record for COL2A1.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Biochem Pharmacol", "doi": "10.1016/j.bcp.2026.118553", "records": [ { "id": "col2a1", "kind": "target", "name": "COL2A1", "url": "https://onco.cc/targets/col2a1/" }, { "id": "kheiron-mia", "kind": "drug", "name": "Mia", "url": "https://onco.cc/drugs/kheiron-mia/" } ] } }, { "id": "https://doi.org/10.1507/endocrj.ej26-0363#onco-edge-paper", "url": "https://doi.org/10.1507/endocrj.ej26-0363", "title": "Growth hormone-releasing hormone-secreting giant pheochromocytoma causing acromegaly: a case report with a review of the literature.", "content_text": "Published in Endocr J on 17 October 2026; matched the OnCo record for Somatotroph pituitary neuroendocrine tumour.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Endocr J", "doi": "10.1507/endocrj.ej26-0363", "records": [ { "id": "somatotroph-pitnet", "kind": "cancer", "name": "Somatotroph pituitary neuroendocrine tumour", "url": "https://onco.cc/cancers/somatotroph-pitnet/" } ] } }, { "id": "https://doi.org/10.1080/13696998.2026.2738358#onco-edge-paper", "url": "https://doi.org/10.1080/13696998.2026.2738358", "title": "Healthcare resource utilization and costs of US patients with small cell lung cancer treated with second-line therapies: a retrospective real-world database study.", "content_text": "Published in J Med Econ on 17 October 2026; matched the OnCo record for Lurbinectedin.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "J Med Econ", "doi": "10.1080/13696998.2026.2738358", "records": [ { "id": "lurbinectedin", "kind": "drug", "name": "Lurbinectedin", "url": "https://onco.cc/drugs/lurbinectedin/" }, { "id": "topotecan", "kind": "drug", "name": "Topotecan", "url": "https://onco.cc/drugs/topotecan/" } ] } }, { "id": "https://doi.org/10.1007/s00210-026-06011-3#onco-edge-paper", "url": "https://doi.org/10.1007/s00210-026-06011-3", "title": "Identification of a novel Microbacterium species and biosynthesis of gold nanoparticles: activation of apoptosis and dysregulation of ABCG transporters in gastric adenocarcinoma cells.", "content_text": "Published in Naunyn Schmiedebergs Arch Pharmacol on 17 October 2026; matched the OnCo record for ABCG2.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Naunyn Schmiedebergs Arch Pharmacol", "doi": "10.1007/s00210-026-06011-3", "records": [ { "id": "abcg2", "kind": "target", "name": "ABCG2", "url": "https://onco.cc/targets/abcg2/" } ] } }, { "id": "https://doi.org/10.1007/s00011-026-02391-7#onco-edge-paper", "url": "https://doi.org/10.1007/s00011-026-02391-7", "title": "IL-1β/IL-6 inflammatory crosstalk drives DNA methylation and histone remodeling associated with cytokine induced senescence in luminal breast cancer.", "content_text": "Published in Inflamm Res on 17 October 2026; matched the OnCo record for DNMT3B.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Inflamm Res", "doi": "10.1007/s00011-026-02391-7", "records": [ { "id": "dnmt3b", "kind": "target", "name": "DNMT3B", "url": "https://onco.cc/targets/dnmt3b/" } ] } }, { "id": "https://doi.org/10.1002/ohn.70411#onco-edge-paper", "url": "https://doi.org/10.1002/ohn.70411", "title": "Immune Profiles and Immunotherapy Efficacy in Sinonasal Malignancies: A Scoping Review.", "content_text": "Published in Otolaryngol Head Neck Surg on 17 October 2026; matched the OnCo record for Esthesioneuroblastoma.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Otolaryngol Head Neck Surg", "doi": "10.1002/ohn.70411", "records": [ { "id": "esthesioneuroblastoma", "kind": "cancer", "name": "Esthesioneuroblastoma", "url": "https://onco.cc/cancers/esthesioneuroblastoma/" }, { "id": "sinonasal-undifferentiated-carcinoma", "kind": "cancer", "name": "Sinonasal undifferentiated carcinoma (SNUC) and SWI/SNF-deficient sinonasal carcinoma", "url": "https://onco.cc/cancers/sinonasal-undifferentiated-carcinoma/" }, { "id": "sinonasal", "kind": "cancer", "name": "Nasal cavity and paranasal sinus cancers", "url": "https://onco.cc/cancers/sinonasal/" } ] } }, { "id": "https://doi.org/10.1007/s10142-026-02066-w#onco-edge-paper", "url": "https://doi.org/10.1007/s10142-026-02066-w", "title": "Integrative transcriptomic analysis reveals tumor-adjacent mucosal remodeling in colorectal cancer.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and Single-cell & spatial profiling.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.1007/s10142-026-02066-w", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.1186/s12886-026-05455-8#onco-edge-paper", "url": "https://doi.org/10.1186/s12886-026-05455-8", "title": "Intravitreal methotrexate as a prophylactic strategy for proliferative vitreoretinopathy in high-risk retinal detachment.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched Methotrexate and CD155.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.1186/s12886-026-05455-8", "records": [ { "id": "methotrexate", "kind": "drug", "name": "Methotrexate", "url": "https://onco.cc/drugs/methotrexate/" }, { "id": "pvr", "kind": "target", "name": "CD155", "url": "https://onco.cc/targets/pvr/" } ] } }, { "id": "https://doi.org/10.1007/s11604-026-02099-y#onco-edge-paper", "url": "https://doi.org/10.1007/s11604-026-02099-y", "title": "MRI-defined parametrial venous invasion in locally advanced cervical cancer: association with pathological venous invasion, pretreatment lymph node metastasis, and survival outcomes.", "content_text": "Published in Jpn J Radiol on 17 October 2026; matched the OnCo record for Locally advanced cervical cancer.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Jpn J Radiol", "doi": "10.1007/s11604-026-02099-y", "records": [ { "id": "locally-advanced-cervical-cancer", "kind": "cancer", "name": "Locally advanced cervical cancer", "url": "https://onco.cc/cancers/locally-advanced-cervical-cancer/" } ] } }, { "id": "https://doi.org/10.1016/j.ctim.2026.103449#onco-edge-paper", "url": "https://doi.org/10.1016/j.ctim.2026.103449", "title": "Multidimensional Clinical Benefits of Cinnamon Leaf Oil Inhalation in Primary and Metastatic Brain Tumor Patients During Winter: A Randomized Controlled Trial.", "content_text": "Published in Complement Ther Med on 17 October 2026; matched the OnCo record for Aromatherapy.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Complement Ther Med", "doi": "10.1016/j.ctim.2026.103449", "records": [ { "id": "aromatherapy-cancer", "kind": "technology", "name": "Aromatherapy", "url": "https://onco.cc/technologies/aromatherapy-cancer/" } ] } }, { "id": "https://doi.org/10.1016/j.mri.2026.110814#onco-edge-paper", "url": "https://doi.org/10.1016/j.mri.2026.110814", "title": "Multiparametric MRI with amide proton transfer imaging for assessing stromal invasion depth of early- stage cervical cancer.", "content_text": "Published in Magn Reson Imaging on 17 October 2026; matched the OnCo record for Early cervical cancer and fertility-sparing surgery.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Magn Reson Imaging", "doi": "10.1016/j.mri.2026.110814", "records": [ { "id": "early-cervical-cancer", "kind": "cancer", "name": "Early cervical cancer and fertility-sparing surgery", "url": "https://onco.cc/cancers/early-cervical-cancer/" } ] } }, { "id": "https://doi.org/10.1016/j.cellsig.2026.112951#onco-edge-paper", "url": "https://doi.org/10.1016/j.cellsig.2026.112951", "title": "NECTIN-4 orchestrates macrophage-mediated tumor plasticity in oral squamous cell carcinoma.", "content_text": "Published in Cell Signal on 17 October 2026; matched the OnCo record for ANGPT1.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Cell Signal", "doi": "10.1016/j.cellsig.2026.112951", "records": [ { "id": "angpt1", "kind": "target", "name": "ANGPT1", "url": "https://onco.cc/targets/angpt1/" }, { "id": "nectin4", "kind": "target", "name": "Nectin-4", "url": "https://onco.cc/targets/nectin4/" } ] } }, { "id": "https://doi.org/10.3390/curroncol33100627#onco-edge-paper", "url": "https://doi.org/10.3390/curroncol33100627", "title": "Nuclear Eccentricity as a Potential Biomarker for Tumor Biology and Survival in Glioblastoma.", "content_text": "Published on 17 October 2026 after first appearing as a preprint; matched SET.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "doi": "10.3390/curroncol33100627", "records": [ { "id": "set", "kind": "target", "name": "SET", "url": "https://onco.cc/targets/set/" } ] } }, { "id": "https://doi.org/10.1016/j.brachy.2026.09.006#onco-edge-paper", "url": "https://doi.org/10.1016/j.brachy.2026.09.006", "title": "Optimization of catheter placement for interstitial gynecological brachytherapy with centroidal Voronoi tessellation.", "content_text": "Published in Brachytherapy on 17 October 2026; matched the OnCo record for Locally advanced cervical cancer.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Brachytherapy", "doi": "10.1016/j.brachy.2026.09.006", "records": [ { "id": "locally-advanced-cervical-cancer", "kind": "cancer", "name": "Locally advanced cervical cancer", "url": "https://onco.cc/cancers/locally-advanced-cervical-cancer/" } ] } }, { "id": "https://doi.org/10.1016/j.jtct.2026.10.027#onco-edge-paper", "url": "https://doi.org/10.1016/j.jtct.2026.10.027", "title": "Outcomes of Allogeneic Stem Cell Transplantation in a North American Adult T Cell Leukemia/Lymphoma Cohort.", "content_text": "Published in Transplant Cell Ther on 17 October 2026; matched the OnCo record for Adult T-cell leukaemia/lymphoma.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Transplant Cell Ther", "doi": "10.1016/j.jtct.2026.10.027", "records": [ { "id": "adult-t-cell-leukaemia-lymphoma", "kind": "cancer", "name": "Adult T-cell leukaemia/lymphoma", "url": "https://onco.cc/cancers/adult-t-cell-leukaemia-lymphoma/" }, { "id": "allogeneic-hsct", "kind": "technology", "name": "Allogeneic stem cell transplantation", "url": "https://onco.cc/technologies/allogeneic-hsct/" } ] } }, { "id": "https://doi.org/10.1007/s11604-026-02094-3#onco-edge-paper", "url": "https://doi.org/10.1007/s11604-026-02094-3", "title": "Palliative radiotherapy for gastric cancer-related bleeding: a systematic review and meta-analysis of bleeding response and dose-response relationships.", "content_text": "Published in Jpn J Radiol on 17 October 2026; matched the OnCo record for Palliative radiotherapy.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Jpn J Radiol", "doi": "10.1007/s11604-026-02094-3", "records": [ { "id": "palliative-radiotherapy", "kind": "technology", "name": "Palliative radiotherapy", "url": "https://onco.cc/technologies/palliative-radiotherapy/" } ] } }, { "id": "https://doi.org/10.1093/omcr/omag194#onco-edge-paper", "url": "https://doi.org/10.1093/omcr/omag194", "title": "Peripheral precocious puberty in a 4-month-old infant associated with an ESR1 variant: a case report.", "content_text": "Published in Oxf Med Case Reports on 17 October 2026; matched the OnCo record for Letrozole.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Oxf Med Case Reports", "doi": "10.1093/omcr/omag194", "records": [ { "id": "letrozole", "kind": "drug", "name": "Letrozole", "url": "https://onco.cc/drugs/letrozole/" } ] } }, { "id": "https://doi.org/10.1038/s41388-026-04015-0#onco-edge-paper", "url": "https://doi.org/10.1038/s41388-026-04015-0", "title": "Phosphorylation of IRS4 at YY111/112 promotes LUSC progression via PI3K/AKT pathway activation.", "content_text": "Published in Oncogene on 17 October 2026; matched the OnCo record for IRS4.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Oncogene", "doi": "10.1038/s41388-026-04015-0", "records": [ { "id": "irs4", "kind": "target", "name": "IRS4", "url": "https://onco.cc/targets/irs4/" } ] } }, { "id": "https://doi.org/10.1016/j.xpro.2026.104904#onco-edge-paper", "url": "https://doi.org/10.1016/j.xpro.2026.104904", "title": "Protocol for eVLP-mediated CRISPR-Cas9 and prime editing in pancreatic cancer cell lines.", "content_text": "Published in STAR Protoc on 17 October 2026; matched the OnCo record for EPHA8.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "STAR Protoc", "doi": "10.1016/j.xpro.2026.104904", "records": [ { "id": "epha8", "kind": "target", "name": "EPHA8", "url": "https://onco.cc/targets/epha8/" } ] } }, { "id": "https://doi.org/10.1016/j.ejphar.2026.179438#onco-edge-paper", "url": "https://doi.org/10.1016/j.ejphar.2026.179438", "title": "Repurposing Entrectinib and Ibrutinib as MNK/eIF4E Pathway Modulators in Ovarian Cancer.", "content_text": "Published in Eur J Pharmacol on 17 October 2026; matched the OnCo record for Entrectinib.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Eur J Pharmacol", "doi": "10.1016/j.ejphar.2026.179438", "records": [ { "id": "entrectinib", "kind": "drug", "name": "Entrectinib", "url": "https://onco.cc/drugs/entrectinib/" } ] } }, { "id": "https://doi.org/10.1016/j.urolonc.2026.09.015#onco-edge-paper", "url": "https://doi.org/10.1016/j.urolonc.2026.09.015", "title": "Restricted mean survival time-based network meta-analysis of first-line therapies for metastatic clear cell renal cell carcinoma.", "content_text": "Published in Urol Oncol on 17 October 2026; matched the OnCo record for Avelumab.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Urol Oncol", "doi": "10.1016/j.urolonc.2026.09.015", "records": [ { "id": "avelumab", "kind": "drug", "name": "Avelumab", "url": "https://onco.cc/drugs/avelumab/" }, { "id": "cabozantinib", "kind": "drug", "name": "Cabozantinib", "url": "https://onco.cc/drugs/cabozantinib/" }, { "id": "ipilimumab", "kind": "drug", "name": "Ipilimumab", "url": "https://onco.cc/drugs/ipilimumab/" } ] } }, { "id": "https://doi.org/10.1007/s10585-026-10443-9#onco-edge-paper", "url": "https://doi.org/10.1007/s10585-026-10443-9", "title": "THINKERS-X: multisequence MRI radiomics in a mixture-of-experts model for outcome prediction and exploratory dose-scenario evaluation in lung cancer brain metastases treated with radiosurgery.", "content_text": "Published in Clin Exp Metastasis on 17 October 2026; matched the OnCo record for Gamma Knife.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Clin Exp Metastasis", "doi": "10.1007/s10585-026-10443-9", "records": [ { "id": "gamma-knife", "kind": "technology", "name": "Gamma Knife", "url": "https://onco.cc/technologies/gamma-knife/" } ] } }, { "id": "https://doi.org/10.1002/1878-0261.70351#onco-edge-paper", "url": "https://doi.org/10.1002/1878-0261.70351", "title": "Tumour-proximal deep serum proteomics identifies biomarkers associated with ovarian cancer.", "content_text": "Published in Mol Oncol on 17 October 2026; matched the OnCo record for ANK1.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Mol Oncol", "doi": "10.1002/1878-0261.70351", "records": [ { "id": "ank1", "kind": "target", "name": "ANK1", "url": "https://onco.cc/targets/ank1/" } ] } }, { "id": "https://doi.org/10.1093/bjd/ljag466#onco-edge-paper", "url": "https://doi.org/10.1093/bjd/ljag466", "title": "When response lasts: ORR4 as an On-Treatment Prognostic Marker in Mogamulizumab-Treated Mycosis Fungoides and Sézary Syndrome.", "content_text": "Published in Br J Dermatol on 17 October 2026; matched the OnCo record for Mogamulizumab.", "date_published": "2026-10-17T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-17", "precision": "day", "venue": "Br J Dermatol", "doi": "10.1093/bjd/ljag466", "records": [ { "id": "mogamulizumab", "kind": "drug", "name": "Mogamulizumab", "url": "https://onco.cc/drugs/mogamulizumab/" }, { "id": "sezary-syndrome", "kind": "cancer", "name": "Sezary syndrome", "url": "https://onco.cc/cancers/sezary-syndrome/" } ] } }, { "id": "https://doi.org/10.3892/ijo.2026.5948#onco-edge-paper", "url": "https://doi.org/10.3892/ijo.2026.5948", "title": "[Corrigendum] Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER‑inhibitors is accompanied by increased sensitivity to STAT3 inhibition.", "content_text": "Published in Int J Oncol on 16 October 2026; matched the OnCo record for STAT3.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Int J Oncol", "doi": "10.3892/ijo.2026.5948", "records": [ { "id": "stat3", "kind": "target", "name": "STAT3", "url": "https://onco.cc/targets/stat3/" } ] } }, { "id": "https://doi.org/10.65868/syff9630#onco-edge-paper", "url": "https://doi.org/10.65868/syff9630", "title": "[Patients with papillary craniopharyngioma successfully treated with BRAF and MEK inhibitors].", "content_text": "Published in Lakartidningen on 16 October 2026; matched the OnCo record for Craniopharyngioma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Lakartidningen", "doi": "10.65868/syff9630", "records": [ { "id": "craniopharyngioma", "kind": "cancer", "name": "Craniopharyngioma", "url": "https://onco.cc/cancers/craniopharyngioma/" } ] } }, { "id": "https://doi.org/10.3892/ijo.2026.5950#onco-edge-paper", "url": "https://doi.org/10.3892/ijo.2026.5950", "title": "<i>Disporum cantoniense</i> suppresses non‑small cell lung cancer through AMPK/mTOR/ULK1‑mediated autophagy‑dependent apoptosis.", "content_text": "Published in Int J Oncol on 16 October 2026; matched the OnCo record for ATG7.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Int J Oncol", "doi": "10.3892/ijo.2026.5950", "records": [ { "id": "atg7", "kind": "target", "name": "ATG7", "url": "https://onco.cc/targets/atg7/" }, { "id": "bax", "kind": "target", "name": "BAX", "url": "https://onco.cc/targets/bax/" }, { "id": "bcl2", "kind": "target", "name": "BCL-2", "url": "https://onco.cc/targets/bcl2/" } ] } }, { "id": "https://doi.org/10.1200/po-26-00484#onco-edge-paper", "url": "https://doi.org/10.1200/po-26-00484", "title": "<i>PIK3CA</i> Mutations in Advanced or Recurrent Endometrial Cancer: An Exploratory Molecular Profiling From the Phase II MITO END-3 Study.", "content_text": "Published in JCO Precis Oncol on 16 October 2026; matched the OnCo record for Advanced or recurrent endometrial cancer.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "JCO Precis Oncol", "doi": "10.1200/po-26-00484", "records": [ { "id": "advanced-recurrent-endometrial-cancer", "kind": "cancer", "name": "Advanced or recurrent endometrial cancer", "url": "https://onco.cc/cancers/advanced-recurrent-endometrial-cancer/" }, { "id": "alpelisib", "kind": "drug", "name": "Alpelisib", "url": "https://onco.cc/drugs/alpelisib/" }, { "id": "arid1a", "kind": "target", "name": "ARID1A", "url": "https://onco.cc/targets/arid1a/" } ] } }, { "id": "https://doi.org/10.1007/s11102-026-01770-x#onco-edge-paper", "url": "https://doi.org/10.1007/s11102-026-01770-x", "title": "<sup>68</sup>Ga-Pentixafor PET/MRI for identifying corticotroph adenomas in Cushing disease: a pilot study.", "content_text": "Published in Pituitary on 16 October 2026; matched the OnCo record for PET/MRI.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Pituitary", "doi": "10.1007/s11102-026-01770-x", "records": [ { "id": "pet-mri", "kind": "technology", "name": "PET/MRI", "url": "https://onco.cc/technologies/pet-mri/" } ] } }, { "id": "https://doi.org/10.1016/j.cellsig.2026.112952#onco-edge-paper", "url": "https://doi.org/10.1016/j.cellsig.2026.112952", "title": "A cytoplasmic cis-acting circuit confines PI3K/AKT-driven lineage plasticity in bladder cancer.", "content_text": "Published in Cell Signal on 16 October 2026; matched the OnCo record for UBC.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Cell Signal", "doi": "10.1016/j.cellsig.2026.112952", "records": [ { "id": "ubc", "kind": "target", "name": "UBC", "url": "https://onco.cc/targets/ubc/" } ] } }, { "id": "https://doi.org/10.1016/j.clinsp.2026.101212#onco-edge-paper", "url": "https://doi.org/10.1016/j.clinsp.2026.101212", "title": "A multimodal MRI radiomics sonata for differentiating small renal masses: a two-center retrospective study.", "content_text": "Published in Clinics (Sao Paulo) on 16 October 2026; matched the OnCo record for SRMS.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Clinics (Sao Paulo)", "doi": "10.1016/j.clinsp.2026.101212", "records": [ { "id": "srms", "kind": "target", "name": "SRMS", "url": "https://onco.cc/targets/srms/" } ] } }, { "id": "https://doi.org/10.1007/s10653-026-03532-x#onco-edge-paper", "url": "https://doi.org/10.1007/s10653-026-03532-x", "title": "A performance evaluation of a multi-soil-layering for the treatment of an olive mill wastewater.", "content_text": "Published in Environ Geochem Health on 16 October 2026; matched the OnCo record for Mesenchymal stem-like triple-negative breast cancer.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Environ Geochem Health", "doi": "10.1007/s10653-026-03532-x", "records": [ { "id": "tnbc-mesenchymal-stem-like", "kind": "cancer", "name": "Mesenchymal stem-like triple-negative breast cancer", "url": "https://onco.cc/cancers/tnbc-mesenchymal-stem-like/" } ] } }, { "id": "https://doi.org/10.1007/s10616-026-01086-5#onco-edge-paper", "url": "https://doi.org/10.1007/s10616-026-01086-5", "title": "A prognostic model based on seven cell adhesion molecule-related genes to predict the prognosis of colorectal cancer.", "content_text": "Published in Cytotechnology on 16 October 2026; matched the OnCo record for Dasatinib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Cytotechnology", "doi": "10.1007/s10616-026-01086-5", "records": [ { "id": "dasatinib", "kind": "drug", "name": "Dasatinib", "url": "https://onco.cc/drugs/dasatinib/" }, { "id": "erlotinib", "kind": "drug", "name": "Erlotinib", "url": "https://onco.cc/drugs/erlotinib/" }, { "id": "gemcitabine", "kind": "drug", "name": "Gemcitabine", "url": "https://onco.cc/drugs/gemcitabine/" }, { "id": "imatinib", "kind": "drug", "name": "Imatinib", "url": "https://onco.cc/drugs/imatinib/" }, { "id": "lapatinib", "kind": "drug", "name": "Lapatinib", "url": "https://onco.cc/drugs/lapatinib/" } ] } }, { "id": "https://doi.org/10.1016/j.dld.2026.09.026#onco-edge-paper", "url": "https://doi.org/10.1016/j.dld.2026.09.026", "title": "A robust biomarker combining radiomic and CA19.9 information to predict distant relapse-free survival after radiochemotherapy in pancreatic cancer.", "content_text": "Published in Dig Liver Dis on 16 October 2026; matched the OnCo record for Locally advanced unresectable pancreatic ductal adenocarcinoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Dig Liver Dis", "doi": "10.1016/j.dld.2026.09.026", "records": [ { "id": "locally-advanced-pdac", "kind": "cancer", "name": "Locally advanced unresectable pancreatic ductal adenocarcinoma", "url": "https://onco.cc/cancers/locally-advanced-pdac/" } ] } }, { "id": "https://doi.org/10.1016/j.euf.2026.09.007#onco-edge-paper", "url": "https://doi.org/10.1016/j.euf.2026.09.007", "title": "Active Surveillance for Intermediate-risk Prostate Cancer: Implications of AI-enabled Pattern Quantification.", "content_text": "Published in Eur Urol Focus on 16 October 2026; matched the OnCo record for Localised prostate cancer, intermediate risk.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Eur Urol Focus", "doi": "10.1016/j.euf.2026.09.007", "records": [ { "id": "prostate-intermediate-risk", "kind": "cancer", "name": "Localised prostate cancer, intermediate risk", "url": "https://onco.cc/cancers/prostate-intermediate-risk/" } ] } }, { "id": "https://doi.org/10.3892/or.2026.9210#onco-edge-paper", "url": "https://doi.org/10.3892/or.2026.9210", "title": "Advances in neoadjuvant therapy for locally advanced head and neck squamous cell carcinoma (Review).", "content_text": "Published in Oncol Rep on 16 October 2026; matched the OnCo record for Cetuximab.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Oncol Rep", "doi": "10.3892/or.2026.9210", "records": [ { "id": "cetuximab", "kind": "drug", "name": "Cetuximab", "url": "https://onco.cc/drugs/cetuximab/" }, { "id": "cytotoxic-chemotherapy", "kind": "technology", "name": "Cytotoxic chemotherapy", "url": "https://onco.cc/technologies/cytotoxic-chemotherapy/" }, { "id": "fluorouracil", "kind": "drug", "name": "Fluorouracil", "url": "https://onco.cc/drugs/fluorouracil/" }, { "id": "head-and-neck", "kind": "cancer", "name": "Head and neck squamous cell carcinoma", "url": "https://onco.cc/cancers/head-and-neck/" }, { "id": "monoclonal-antibody", "kind": "technology", "name": "Monoclonal antibodies", "url": "https://onco.cc/technologies/monoclonal-antibody/" } ] } }, { "id": "https://doi.org/10.1038/s41592-026-03264-x#onco-edge-paper", "url": "https://doi.org/10.1038/s41592-026-03264-x", "title": "AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched Whole-exome & whole-genome sequencing.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.1038/s41592-026-03264-x", "records": [ { "id": "wes-wgs", "kind": "technology", "name": "Whole-exome & whole-genome sequencing", "url": "https://onco.cc/technologies/wes-wgs/" } ] } }, { "id": "https://doi.org/10.1080/14712598.2026.2742404#onco-edge-paper", "url": "https://doi.org/10.1080/14712598.2026.2742404", "title": "An evaluation of sacituzumab tirumotecan for the treatment of NSCLC.", "content_text": "Published in Expert Opin Biol Ther on 16 October 2026; matched the OnCo record for Sacituzumab tirumotecan.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Expert Opin Biol Ther", "doi": "10.1080/14712598.2026.2742404", "records": [ { "id": "sacituzumab-tirumotecan", "kind": "drug", "name": "Sacituzumab tirumotecan", "url": "https://onco.cc/drugs/sacituzumab-tirumotecan/" } ] } }, { "id": "https://doi.org/10.1111/hepr.70274#onco-edge-paper", "url": "https://doi.org/10.1111/hepr.70274", "title": "An Integrative Multi-Omic Biomarker Panel Distinguishes Hepatocellular Carcinoma From Chronic Liver Disease in HBV-Predominant Populations.", "content_text": "Published in Hepatol Res on 16 October 2026; matched the OnCo record for Diethylstilbestrol.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Hepatol Res", "doi": "10.1111/hepr.70274", "records": [ { "id": "diethylstilbestrol", "kind": "drug", "name": "Diethylstilbestrol", "url": "https://onco.cc/drugs/diethylstilbestrol/" } ] } }, { "id": "https://doi.org/10.1007/s10495-026-02463-3#onco-edge-paper", "url": "https://doi.org/10.1007/s10495-026-02463-3", "title": "Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation.", "content_text": "Published in Apoptosis on 16 October 2026; matched the OnCo record for Epirubicin.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Apoptosis", "doi": "10.1007/s10495-026-02463-3", "records": [ { "id": "epirubicin", "kind": "drug", "name": "Epirubicin", "url": "https://onco.cc/drugs/epirubicin/" }, { "id": "klf4", "kind": "target", "name": "KLF4", "url": "https://onco.cc/targets/klf4/" } ] } }, { "id": "https://doi.org/10.1245/s10434-026-20588-2#onco-edge-paper", "url": "https://doi.org/10.1245/s10434-026-20588-2", "title": "ASO Visual Abstract: Does Additional Margin Excision During Pegulicianine Fluorescence-Guided Surgery (pFGS) Affect Patient Breast Satisfaction?", "content_text": "Published in Ann Surg Oncol on 16 October 2026; matched the OnCo record for Pegulicianine.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Ann Surg Oncol", "doi": "10.1245/s10434-026-20588-2", "records": [ { "id": "pegulicianine", "kind": "drug", "name": "Pegulicianine", "url": "https://onco.cc/drugs/pegulicianine/" } ] } }, { "id": "https://doi.org/10.1212/wnl.0000000000218584#onco-edge-paper", "url": "https://doi.org/10.1212/wnl.0000000000218584", "title": "Associations of Antibodies Against Several Infections With Alzheimer Disease Neuropathology: A Prospective Cohort Study Analysis.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched CCDC6 and APOE.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.1212/wnl.0000000000218584", "records": [ { "id": "ccdc6", "kind": "target", "name": "CCDC6", "url": "https://onco.cc/targets/ccdc6/" }, { "id": "apoe", "kind": "target", "name": "APOE", "url": "https://onco.cc/targets/apoe/" } ] } }, { "id": "https://doi.org/10.1177/10781552261499517#onco-edge-paper", "url": "https://doi.org/10.1177/10781552261499517", "title": "Author response to the Letter to the Editor: \"Model informed precision dosing for most accurate busulfan therapeutic drug monitoring\".", "content_text": "Published in J Oncol Pharm Pract on 16 October 2026; matched the OnCo record for Busulfan.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Oncol Pharm Pract", "doi": "10.1177/10781552261499517", "records": [ { "id": "busulfan", "kind": "drug", "name": "Busulfan", "url": "https://onco.cc/drugs/busulfan/" } ] } }, { "id": "https://doi.org/10.1186/s11671-026-04997-6#onco-edge-paper", "url": "https://doi.org/10.1186/s11671-026-04997-6", "title": "Bibliometric mapping of research trends and publication growth in cancer sonodynamic therapy from 2001 to 2025.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched Sonodynamic therapy.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.1186/s11671-026-04997-6", "records": [ { "id": "sonodynamic-therapy", "kind": "technology", "name": "Sonodynamic therapy", "url": "https://onco.cc/technologies/sonodynamic-therapy/" } ] } }, { "id": "https://doi.org/10.1016/j.critrevonc.2026.105646#onco-edge-paper", "url": "https://doi.org/10.1016/j.critrevonc.2026.105646", "title": "Cardiovascular Toxicities Associated With Immune Checkpoint Inhibitors: Clinical Phenotypes, Mechanisms, Diagnosis, and Management-A Narrative Review.", "content_text": "Published in Crit Rev Oncol Hematol on 16 October 2026; matched the OnCo record for Alemtuzumab.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Crit Rev Oncol Hematol", "doi": "10.1016/j.critrevonc.2026.105646", "records": [ { "id": "alemtuzumab", "kind": "drug", "name": "Alemtuzumab", "url": "https://onco.cc/drugs/alemtuzumab/" } ] } }, { "id": "https://doi.org/10.1016/j.tranon.2026.103080#onco-edge-paper", "url": "https://doi.org/10.1016/j.tranon.2026.103080", "title": "Cell-free DNA fragmentomics and epigenomic profiling in hematologic malignancies: current evidence, translational limitations, and future directions.", "content_text": "Published in Transl Oncol on 16 October 2026; matched the OnCo record for cfDNA fragmentomics.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Transl Oncol", "doi": "10.1016/j.tranon.2026.103080", "records": [ { "id": "fragmentomics", "kind": "technology", "name": "cfDNA fragmentomics", "url": "https://onco.cc/technologies/fragmentomics/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aed4155#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aed4155", "title": "CellDiffusion: Enhancing scRNA-seq data integration with accurate inference of cell-cell association.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched Single-cell & spatial profiling.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.1126/sciadv.aed4155", "records": [ { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.1111/ejh.70340#onco-edge-paper", "url": "https://doi.org/10.1111/ejh.70340", "title": "Chimeric Antigen Receptor T-Cell Therapy in T Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Systematic Review and Meta-Analysis.", "content_text": "Published in Eur J Haematol on 16 October 2026; matched the OnCo record for T-cell/histiocyte-rich large B-cell lymphoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Eur J Haematol", "doi": "10.1111/ejh.70340", "records": [ { "id": "t-cell-histiocyte-rich-large-b-cell-lymphoma", "kind": "cancer", "name": "T-cell/histiocyte-rich large B-cell lymphoma", "url": "https://onco.cc/cancers/t-cell-histiocyte-rich-large-b-cell-lymphoma/" } ] } }, { "id": "https://doi.org/10.1182/bloodadvances.2025019251#onco-edge-paper", "url": "https://doi.org/10.1182/bloodadvances.2025019251", "title": "Clinical characteristics and outcome of a cohort of CLL patients with BTK T474 gatekeeper mutation.", "content_text": "Published in Blood Adv on 16 October 2026; matched the OnCo record for Acalabrutinib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Blood Adv", "doi": "10.1182/bloodadvances.2025019251", "records": [ { "id": "acalabrutinib", "kind": "drug", "name": "Acalabrutinib", "url": "https://onco.cc/drugs/acalabrutinib/" }, { "id": "cll-relapsed", "kind": "cancer", "name": "Relapsed or refractory chronic lymphocytic leukaemia", "url": "https://onco.cc/cancers/cll-relapsed/" }, { "id": "nemtabrutinib", "kind": "drug", "name": "Nemtabrutinib", "url": "https://onco.cc/drugs/nemtabrutinib/" }, { "id": "pirtobrutinib", "kind": "drug", "name": "Pirtobrutinib", "url": "https://onco.cc/drugs/pirtobrutinib/" }, { "id": "sf3b1", "kind": "target", "name": "SF3B1", "url": "https://onco.cc/targets/sf3b1/" } ] } }, { "id": "https://doi.org/10.1200/po-26-00703#onco-edge-paper", "url": "https://doi.org/10.1200/po-26-00703", "title": "Cobimetinib + Vemurafenib in Patients With <i>BRAF</i> V600E-Mutant Papillary Thyroid and Biliary Tract Cancers: Results From the TAPUR Study.", "content_text": "Published in JCO Precis Oncol on 16 October 2026; matched the OnCo record for Cobimetinib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "JCO Precis Oncol", "doi": "10.1200/po-26-00703", "records": [ { "id": "cobimetinib", "kind": "drug", "name": "Cobimetinib", "url": "https://onco.cc/drugs/cobimetinib/" }, { "id": "vemurafenib", "kind": "drug", "name": "Vemurafenib", "url": "https://onco.cc/drugs/vemurafenib/" } ] } }, { "id": "https://doi.org/10.1371/journal.pcbi.1014862#onco-edge-paper", "url": "https://doi.org/10.1371/journal.pcbi.1014862", "title": "Computational deconvolution of drug sensitivity via single-cell-to-bulk transcriptome mapping.", "content_text": "Published in PLoS Comput Biol on 16 October 2026; matched the OnCo record for Midostaurin.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "PLoS Comput Biol", "doi": "10.1371/journal.pcbi.1014862", "records": [ { "id": "midostaurin", "kind": "drug", "name": "Midostaurin", "url": "https://onco.cc/drugs/midostaurin/" } ] } }, { "id": "https://doi.org/10.1080/14656566.2026.2749642#onco-edge-paper", "url": "https://doi.org/10.1080/14656566.2026.2749642", "title": "Current perspectives in the pharmacological combination treatment for low-grade serous ovarian cancer.", "content_text": "Published in Expert Opin Pharmacother on 16 October 2026; matched the OnCo record for Avutometinib + defactinib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Expert Opin Pharmacother", "doi": "10.1080/14656566.2026.2749642", "records": [ { "id": "avutometinib-defactinib", "kind": "drug", "name": "Avutometinib + defactinib", "url": "https://onco.cc/drugs/avutometinib-defactinib/" }, { "id": "low-grade-serous-ovarian-cancer", "kind": "cancer", "name": "Low-grade serous ovarian cancer", "url": "https://onco.cc/cancers/low-grade-serous-ovarian-cancer/" } ] } }, { "id": "https://doi.org/10.3390/jcm15208047#onco-edge-paper", "url": "https://doi.org/10.3390/jcm15208047", "title": "Current State of Adjuvant Hormone Therapy in Prostate Cancer and in the Management of Pelvic Nodal Recurrence: A Narrative Review.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched Androgen deprivation & AR pathway inhibitors and State.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.3390/jcm15208047", "records": [ { "id": "androgen-deprivation", "kind": "technology", "name": "Androgen deprivation & AR pathway inhibitors", "url": "https://onco.cc/technologies/androgen-deprivation/" }, { "id": "state-arc", "kind": "technology", "name": "State", "url": "https://onco.cc/technologies/state-arc/" } ] } }, { "id": "https://doi.org/10.1002/bco2.70289#onco-edge-paper", "url": "https://doi.org/10.1002/bco2.70289", "title": "Decision regret after partial nephrectomy for benign small renal masses: The importance of preoperative counselling.", "content_text": "Published in BJUI Compass on 16 October 2026; matched the OnCo record for SRMS.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "BJUI Compass", "doi": "10.1002/bco2.70289", "records": [ { "id": "srms", "kind": "target", "name": "SRMS", "url": "https://onco.cc/targets/srms/" } ] } }, { "id": "https://doi.org/10.1021/acssensors.6c01896#onco-edge-paper", "url": "https://doi.org/10.1021/acssensors.6c01896", "title": "Dielectrophoresis-Assisted PVDF/DES/Au NP-Based Microfluidic ECL Biosensor for In Situ Detection of Extracellular Vesicles.", "content_text": "Published in ACS Sens on 16 October 2026; matched the OnCo record for Diethylstilbestrol.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "ACS Sens", "doi": "10.1021/acssensors.6c01896", "records": [ { "id": "diethylstilbestrol", "kind": "drug", "name": "Diethylstilbestrol", "url": "https://onco.cc/drugs/diethylstilbestrol/" } ] } }, { "id": "https://doi.org/10.1039/d6fo02463g#onco-edge-paper", "url": "https://doi.org/10.1039/d6fo02463g", "title": "Dietary anthocyanins as multifunctional bioactives targeting obesity across experimental and clinical models.", "content_text": "Published in Food Funct on 16 October 2026; matched the OnCo record for PRDM16.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Food Funct", "doi": "10.1039/d6fo02463g", "records": [ { "id": "prdm16", "kind": "target", "name": "PRDM16", "url": "https://onco.cc/targets/prdm16/" } ] } }, { "id": "https://doi.org/10.1038/s41388-026-04017-y#onco-edge-paper", "url": "https://doi.org/10.1038/s41388-026-04017-y", "title": "Dynamic remodeling of the KRAS interactome by direct RAS inhibitors with distinct mechanism of action reveals convergent responses.", "content_text": "Published in Oncogene on 16 October 2026; matched the OnCo record for AFDN.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Oncogene", "doi": "10.1038/s41388-026-04017-y", "records": [ { "id": "afdn", "kind": "target", "name": "AFDN", "url": "https://onco.cc/targets/afdn/" } ] } }, { "id": "https://doi.org/10.3892/mmr.2026.14043#onco-edge-paper", "url": "https://doi.org/10.3892/mmr.2026.14043", "title": "Epigallocatechin gallate and thermal cycling‑stimulation synergistically promote apoptosis in A549 cells via endoplasmic reticulum stress‑induced calcium ion dysregulation and oxidative stress.", "content_text": "Published in Mol Med Rep on 16 October 2026; matched the OnCo record for Proteasome.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Med Rep", "doi": "10.3892/mmr.2026.14043", "records": [ { "id": "proteasome", "kind": "target", "name": "Proteasome", "url": "https://onco.cc/targets/proteasome/" } ] } }, { "id": "https://doi.org/10.5603/ep.112277#onco-edge-paper", "url": "https://doi.org/10.5603/ep.112277", "title": "Exposure to hypothyroid serum alters expression of oncogenes and tumor suppressors in preneoplastic breast cells.", "content_text": "Published in Endokrynol Pol on 16 October 2026; matched the OnCo record for AGR2.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Endokrynol Pol", "doi": "10.5603/ep.112277", "records": [ { "id": "agr2", "kind": "target", "name": "AGR2", "url": "https://onco.cc/targets/agr2/" }, { "id": "thrb", "kind": "target", "name": "THRB", "url": "https://onco.cc/targets/thrb/" } ] } }, { "id": "https://doi.org/10.1111/bjh.70889#onco-edge-paper", "url": "https://doi.org/10.1111/bjh.70889", "title": "Flow cytometric assessment of T-cell receptor β-chain constant region 1/2 skewing as a surrogate marker for clonality in human T-cell leukaemia virus type-1-infected cells.", "content_text": "Published in Br J Haematol on 16 October 2026; matched the OnCo record for Adult T-cell leukaemia/lymphoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Br J Haematol", "doi": "10.1111/bjh.70889", "records": [ { "id": "adult-t-cell-leukaemia-lymphoma", "kind": "cancer", "name": "Adult T-cell leukaemia/lymphoma", "url": "https://onco.cc/cancers/adult-t-cell-leukaemia-lymphoma/" } ] } }, { "id": "https://doi.org/10.3892/mmr.2026.14046#onco-edge-paper", "url": "https://doi.org/10.3892/mmr.2026.14046", "title": "Glycyrrhizic acid attenuates corneal inflammation and pathological angiogenesis through FAK/PI3K/AKT signaling.", "content_text": "Published in Mol Med Rep on 16 October 2026; matched the OnCo record for BAX.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Med Rep", "doi": "10.3892/mmr.2026.14046", "records": [ { "id": "bax", "kind": "target", "name": "BAX", "url": "https://onco.cc/targets/bax/" }, { "id": "bcl2", "kind": "target", "name": "BCL-2", "url": "https://onco.cc/targets/bcl2/" }, { "id": "ccnd1", "kind": "target", "name": "CCND1", "url": "https://onco.cc/targets/ccnd1/" }, { "id": "fak", "kind": "target", "name": "FAK", "url": "https://onco.cc/targets/fak/" } ] } }, { "id": "https://doi.org/10.1007/s11033-026-12830-7#onco-edge-paper", "url": "https://doi.org/10.1007/s11033-026-12830-7", "title": "Harnessing the ubiquitin-proteasome system: advances and challenges of PROTACs in breast cancer.", "content_text": "Published in Mol Biol Rep on 16 October 2026; matched the OnCo record for Vepdegestrant.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Biol Rep", "doi": "10.1007/s11033-026-12830-7", "records": [ { "id": "vepdegestrant", "kind": "drug", "name": "Vepdegestrant", "url": "https://onco.cc/drugs/vepdegestrant/" } ] } }, { "id": "https://doi.org/10.1080/1062936x.2026.2741359#onco-edge-paper", "url": "https://doi.org/10.1080/1062936x.2026.2741359", "title": "HDAC8 Assistant: a QSAR-guided molecular generation platform for <i>de novo</i> design and virtual screening of HDAC8 inhibitors.", "content_text": "Published in SAR QSAR Environ Res on 16 October 2026; matched the OnCo record for HDAC8.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "SAR QSAR Environ Res", "doi": "10.1080/1062936x.2026.2741359", "records": [ { "id": "hdac8", "kind": "target", "name": "HDAC8", "url": "https://onco.cc/targets/hdac8/" } ] } }, { "id": "https://doi.org/10.1002/jha2.70395#onco-edge-paper", "url": "https://doi.org/10.1002/jha2.70395", "title": "Hematologic Malignancies With RUNX1::ZFPM2 Translocation: A Case Report and Literature Review.", "content_text": "Published in EJHaem on 16 October 2026; matched the OnCo record for RUNX1T1.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "EJHaem", "doi": "10.1002/jha2.70395", "records": [ { "id": "runx1t1", "kind": "target", "name": "RUNX1T1", "url": "https://onco.cc/targets/runx1t1/" }, { "id": "zfpm2", "kind": "target", "name": "ZFPM2", "url": "https://onco.cc/targets/zfpm2/" } ] } }, { "id": "https://doi.org/10.1007/s11102-026-01776-5#onco-edge-paper", "url": "https://doi.org/10.1007/s11102-026-01776-5", "title": "Higher ARNT expression is associated with the sparsely granulated phenotype in somatotroph pituitary adenomas: An immunohistochemical study.", "content_text": "Published in Pituitary on 16 October 2026; matched the OnCo record for ARNT.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Pituitary", "doi": "10.1007/s11102-026-01776-5", "records": [ { "id": "arnt", "kind": "target", "name": "ARNT", "url": "https://onco.cc/targets/arnt/" } ] } }, { "id": "https://doi.org/10.1080/21645515.2026.2738264#onco-edge-paper", "url": "https://doi.org/10.1080/21645515.2026.2738264", "title": "HPV vaccination coverage and barriers for people with disability: A scoping review.", "content_text": "Published in Hum Vaccin Immunother on 16 October 2026; matched the OnCo record for HPV & HBV vaccination.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Hum Vaccin Immunother", "doi": "10.1080/21645515.2026.2738264", "records": [ { "id": "hpv-vaccine", "kind": "technology", "name": "HPV & HBV vaccination", "url": "https://onco.cc/technologies/hpv-vaccine/" } ] } }, { "id": "https://doi.org/10.4103/ijo.ijo_228_26#onco-edge-paper", "url": "https://doi.org/10.4103/ijo.ijo_228_26", "title": "Hyperprolactinemia and corneal ectasia risk: A tomographic and densitometric analysis in prolactinoma patients.", "content_text": "Published in Indian J Ophthalmol on 16 October 2026; matched the OnCo record for Lactotroph pituitary neuroendocrine tumour.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Indian J Ophthalmol", "doi": "10.4103/ijo.ijo_228_26", "records": [ { "id": "lactotroph-pitnet", "kind": "cancer", "name": "Lactotroph pituitary neuroendocrine tumour", "url": "https://onco.cc/cancers/lactotroph-pitnet/" } ] } }, { "id": "https://doi.org/10.3791/72728#onco-edge-paper", "url": "https://doi.org/10.3791/72728", "title": "Identification of Macrophage Polarization-Related Biomarkers in Multiple Myeloma Using Integrated Bioinformatics.", "content_text": "Published in J Vis Exp on 16 October 2026; matched the OnCo record for IL2RG.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Vis Exp", "doi": "10.3791/72728", "records": [ { "id": "il2rg", "kind": "target", "name": "IL2RG", "url": "https://onco.cc/targets/il2rg/" } ] } }, { "id": "https://doi.org/10.1016/j.ad.2026.104766#onco-edge-paper", "url": "https://doi.org/10.1016/j.ad.2026.104766", "title": "Immunosenescence markers as predictors of cutaneous keratinocyte carcinoma risk in heart transplant recipients: a prospective pilot study of 30 patients.", "content_text": "Published in Actas Dermosifiliogr on 16 October 2026; matched the OnCo record for CD57.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Actas Dermosifiliogr", "doi": "10.1016/j.ad.2026.104766", "records": [ { "id": "cd57", "kind": "target", "name": "CD57", "url": "https://onco.cc/targets/cd57/" } ] } }, { "id": "https://doi.org/10.1007/s40259-026-00809-6#onco-edge-paper", "url": "https://doi.org/10.1007/s40259-026-00809-6", "title": "Incidence and Risk Factors of Treatment-Emergent Eczematous Reactions in Patients with Psoriasis Treated with Biologics: A Systematic Review and Meta-Analysis.", "content_text": "Published in BioDrugs on 16 October 2026; matched the OnCo record for TYK2.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "BioDrugs", "doi": "10.1007/s40259-026-00809-6", "records": [ { "id": "tyk2", "kind": "target", "name": "TYK2", "url": "https://onco.cc/targets/tyk2/" } ] } }, { "id": "https://doi.org/10.1039/d6ay01576j#onco-edge-paper", "url": "https://doi.org/10.1039/d6ay01576j", "title": "Insights into the degradation behaviour of tucatinib under stress conditions using liquid chromatography high resolution tandem mass spectrometry.", "content_text": "Published in Anal Methods on 16 October 2026; matched the OnCo record for Tucatinib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Anal Methods", "doi": "10.1039/d6ay01576j", "records": [ { "id": "tucatinib", "kind": "drug", "name": "Tucatinib", "url": "https://onco.cc/drugs/tucatinib/" } ] } }, { "id": "https://doi.org/10.1016/j.ejphar.2026.179443#onco-edge-paper", "url": "https://doi.org/10.1016/j.ejphar.2026.179443", "title": "Isorhapontigenin alleviates sepsis-induced acute lung injury by targeting the RAF1-ERK1/2-CXCL10 axis to inhibit CXCR3<sup>+</sup> neutrophil recruitment.", "content_text": "Published in Eur J Pharmacol on 16 October 2026; matched the OnCo record for CRAF.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Eur J Pharmacol", "doi": "10.1016/j.ejphar.2026.179443", "records": [ { "id": "raf1", "kind": "target", "name": "CRAF", "url": "https://onco.cc/targets/raf1/" } ] } }, { "id": "https://doi.org/10.1007/s11033-026-12944-y#onco-edge-paper", "url": "https://doi.org/10.1007/s11033-026-12944-y", "title": "ITF2357 exerts anti‑tumor activity in colorectal cancer via the miR‑1938/ADAM12 axis.", "content_text": "Published in Mol Biol Rep on 16 October 2026; matched the OnCo record for Givinostat.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Biol Rep", "doi": "10.1007/s11033-026-12944-y", "records": [ { "id": "givinostat", "kind": "drug", "name": "Givinostat", "url": "https://onco.cc/drugs/givinostat/" } ] } }, { "id": "https://doi.org/10.12659/ajcr.953333#onco-edge-paper", "url": "https://doi.org/10.12659/ajcr.953333", "title": "Large Carinal Chondrosarcoma: Resection of the Main Carina, Distal Trachea, and Orifices of the Mainstem Bronchi and Construction of a New Carina.", "content_text": "Published in Am J Case Rep on 16 October 2026; matched the OnCo record for Chondrosarcoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Am J Case Rep", "doi": "10.12659/ajcr.953333", "records": [ { "id": "chondrosarcoma", "kind": "cancer", "name": "Chondrosarcoma", "url": "https://onco.cc/cancers/chondrosarcoma/" } ] } }, { "id": "https://doi.org/10.1039/d6nr01741j#onco-edge-paper", "url": "https://doi.org/10.1039/d6nr01741j", "title": "Light- and ROS-responsive nanomicelles enable targeted combination photothermal molecular therapy in melanoma cells and spheroids.", "content_text": "Published in Nanoscale on 16 October 2026; matched the OnCo record for PSMC4.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Nanoscale", "doi": "10.1039/d6nr01741j", "records": [ { "id": "psmc4", "kind": "target", "name": "PSMC4", "url": "https://onco.cc/targets/psmc4/" }, { "id": "rps6", "kind": "target", "name": "RPS6", "url": "https://onco.cc/targets/rps6/" } ] } }, { "id": "https://doi.org/10.1007/s10528-026-11451-w#onco-edge-paper", "url": "https://doi.org/10.1007/s10528-026-11451-w", "title": "LncRNA GAS5 Restrains Hepatocellular Carcinoma by Targeting the miR-18a-5p-CADM2 Axis.", "content_text": "Published in Biochem Genet on 16 October 2026; matched the OnCo record for CADM2.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Biochem Genet", "doi": "10.1007/s10528-026-11451-w", "records": [ { "id": "cadm2", "kind": "target", "name": "CADM2", "url": "https://onco.cc/targets/cadm2/" } ] } }, { "id": "https://doi.org/10.1093/ejendo/lvag189#onco-edge-paper", "url": "https://doi.org/10.1093/ejendo/lvag189", "title": "Machine Learning Quantifies Within-Subject Facial Change in Acromegaly.", "content_text": "Published in Eur J Endocrinol on 16 October 2026; matched the OnCo record for Somatotroph pituitary neuroendocrine tumour.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Eur J Endocrinol", "doi": "10.1093/ejendo/lvag189", "records": [ { "id": "somatotroph-pitnet", "kind": "cancer", "name": "Somatotroph pituitary neuroendocrine tumour", "url": "https://onco.cc/cancers/somatotroph-pitnet/" } ] } }, { "id": "https://doi.org/10.1093/jmcb/mjag040#onco-edge-paper", "url": "https://doi.org/10.1093/jmcb/mjag040", "title": "Medium-Frequency Electrotherapy-Driven Remodeling of Tumor Biology and Overcoming Treatment Resistance: Molecular Mechanisms and Clinical Integration.", "content_text": "Published in J Mol Cell Biol on 16 October 2026; matched the OnCo record for Tumour treating fields.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Mol Cell Biol", "doi": "10.1093/jmcb/mjag040", "records": [ { "id": "ttfields", "kind": "technology", "name": "Tumour treating fields", "url": "https://onco.cc/technologies/ttfields/" } ] } }, { "id": "https://doi.org/10.1016/j.ad.2026.104763#onco-edge-paper", "url": "https://doi.org/10.1016/j.ad.2026.104763", "title": "Mohs micrographic surgery for dermatofibrosarcoma protuberans: our experience using frozen sections and a literature review.", "content_text": "Published in Actas Dermosifiliogr on 16 October 2026; matched the OnCo record for Dermatofibrosarcoma protuberans.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Actas Dermosifiliogr", "doi": "10.1016/j.ad.2026.104763", "records": [ { "id": "dermatofibrosarcoma-protuberans", "kind": "cancer", "name": "Dermatofibrosarcoma protuberans", "url": "https://onco.cc/cancers/dermatofibrosarcoma-protuberans/" } ] } }, { "id": "https://doi.org/10.1097/pas.0000000000002629#onco-edge-paper", "url": "https://doi.org/10.1097/pas.0000000000002629", "title": "Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: Clinicopathologic and Genetic Analysis of a Large Chinese Cohort.", "content_text": "Published in Am J Surg Pathol on 16 October 2026; matched the OnCo record for CDKN2B.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Am J Surg Pathol", "doi": "10.1097/pas.0000000000002629", "records": [ { "id": "cdkn2b", "kind": "target", "name": "CDKN2B", "url": "https://onco.cc/targets/cdkn2b/" }, { "id": "jak3", "kind": "target", "name": "JAK3", "url": "https://onco.cc/targets/jak3/" }, { "id": "monomorphic-epitheliotropic-intestinal-t-cell-lymphoma", "kind": "cancer", "name": "Monomorphic epitheliotropic intestinal T-cell lymphoma", "url": "https://onco.cc/cancers/monomorphic-epitheliotropic-intestinal-t-cell-lymphoma/" }, { "id": "sdhd", "kind": "target", "name": "SDHD", "url": "https://onco.cc/targets/sdhd/" }, { "id": "stk11", "kind": "target", "name": "STK11", "url": "https://onco.cc/targets/stk11/" }, { "id": "tp63", "kind": "target", "name": "TP63", "url": "https://onco.cc/targets/tp63/" }, { "id": "tsc2", "kind": "target", "name": "TSC2", "url": "https://onco.cc/targets/tsc2/" } ] } }, { "id": "https://doi.org/10.1186/s13256-026-06615-6#onco-edge-paper", "url": "https://doi.org/10.1186/s13256-026-06615-6", "title": "Multimodal imaging features of nuclear protein in testis carcinoma of the submandibular gland: a case report.", "content_text": "Published in J Med Case Rep on 16 October 2026; matched the OnCo record for NUT carcinoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Med Case Rep", "doi": "10.1186/s13256-026-06615-6", "records": [ { "id": "nut-carcinoma", "kind": "cancer", "name": "NUT carcinoma", "url": "https://onco.cc/cancers/nut-carcinoma/" }, { "id": "mri", "kind": "technology", "name": "MRI", "url": "https://onco.cc/technologies/mri/" }, { "id": "pet", "kind": "technology", "name": "PET", "url": "https://onco.cc/technologies/pet/" }, { "id": "pet-ct", "kind": "technology", "name": "PET/CT", "url": "https://onco.cc/technologies/pet-ct/" } ] } }, { "id": "https://doi.org/10.3892/mmr.2026.14041#onco-edge-paper", "url": "https://doi.org/10.3892/mmr.2026.14041", "title": "Navigating the landscape of targeted therapies for renal cell carcinoma in the era of precision medicine (Review).", "content_text": "Published in Mol Med Rep on 16 October 2026; matched the OnCo record for Axitinib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Med Rep", "doi": "10.3892/mmr.2026.14041", "records": [ { "id": "axitinib", "kind": "drug", "name": "Axitinib", "url": "https://onco.cc/drugs/axitinib/" }, { "id": "brca", "kind": "target", "name": "BRCA1 / BRCA2", "url": "https://onco.cc/targets/brca/" }, { "id": "ipilimumab", "kind": "drug", "name": "Ipilimumab", "url": "https://onco.cc/drugs/ipilimumab/" }, { "id": "lenvatinib", "kind": "drug", "name": "Lenvatinib", "url": "https://onco.cc/drugs/lenvatinib/" }, { "id": "nivolumab", "kind": "drug", "name": "Nivolumab", "url": "https://onco.cc/drugs/nivolumab/" }, { "id": "pbrm1", "kind": "target", "name": "PBRM1", "url": "https://onco.cc/targets/pbrm1/" }, { "id": "pembrolizumab", "kind": "drug", "name": "Pembrolizumab", "url": "https://onco.cc/drugs/pembrolizumab/" }, { "id": "rcc", "kind": "cancer", "name": "Renal cell carcinoma", "url": "https://onco.cc/cancers/rcc/" }, { "id": "sirolimus", "kind": "drug", "name": "Sirolimus", "url": "https://onco.cc/drugs/sirolimus/" }, { "id": "smarca4", "kind": "target", "name": "SMARCA4", "url": "https://onco.cc/targets/smarca4/" } ] } }, { "id": "https://doi.org/10.1245/s10434-026-20713-1#onco-edge-paper", "url": "https://doi.org/10.1245/s10434-026-20713-1", "title": "Neoadjuvant Chemo-Immunotherapy Yields Survival Comparable to Upfront Surgery in Metaplastic Breast Cancer: A National Cancer Database Analysis.", "content_text": "Published in Ann Surg Oncol on 16 October 2026; matched the OnCo record for Metaplastic breast carcinoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Ann Surg Oncol", "doi": "10.1245/s10434-026-20713-1", "records": [ { "id": "metaplastic-breast-carcinoma", "kind": "cancer", "name": "Metaplastic breast carcinoma", "url": "https://onco.cc/cancers/metaplastic-breast-carcinoma/" } ] } }, { "id": "https://doi.org/10.1007/s10238-026-02311-3#onco-edge-paper", "url": "https://doi.org/10.1007/s10238-026-02311-3", "title": "Oncolytic virotherapy for cancer: biological mechanisms, clinical advances, and future perspectives.", "content_text": "Published in Clin Exp Med on 16 October 2026; matched the OnCo record for Talimogene laherparepvec.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Clin Exp Med", "doi": "10.1007/s10238-026-02311-3", "records": [ { "id": "talimogene-laherparepvec", "kind": "drug", "name": "Talimogene laherparepvec", "url": "https://onco.cc/drugs/talimogene-laherparepvec/" } ] } }, { "id": "https://doi.org/10.1080/14756366.2026.2743434#onco-edge-paper", "url": "https://doi.org/10.1080/14756366.2026.2743434", "title": "Optimisation and mechanistic characterization of a selective benzoxazine-based MAP4K4 inhibitor in pancreatic cancer cells.", "content_text": "Published in J Enzyme Inhib Med Chem on 16 October 2026; matched the OnCo record for AIMP2.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Enzyme Inhib Med Chem", "doi": "10.1080/14756366.2026.2743434", "records": [ { "id": "aimp2", "kind": "target", "name": "AIMP2", "url": "https://onco.cc/targets/aimp2/" } ] } }, { "id": "https://doi.org/10.1016/j.micpath.2026.108878#onco-edge-paper", "url": "https://doi.org/10.1016/j.micpath.2026.108878", "title": "PA4933 Mediates Dual Regulation of Oxidative Resistance and Virulence in Pseudomonas aeruginosa Pulmonary Infection.", "content_text": "Published in Microb Pathog on 16 October 2026; matched the OnCo record for Primary effusion lymphoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Microb Pathog", "doi": "10.1016/j.micpath.2026.108878", "records": [ { "id": "primary-effusion-lymphoma", "kind": "cancer", "name": "Primary effusion lymphoma", "url": "https://onco.cc/cancers/primary-effusion-lymphoma/" } ] } }, { "id": "https://doi.org/10.1038/s41418-026-01870-y#onco-edge-paper", "url": "https://doi.org/10.1038/s41418-026-01870-y", "title": "PABPC1 dictates castration sensitivity in prostate cancer via orchestrating ferroptosis resistance and CD8(+) T-cell dysfunction.", "content_text": "Published in Cell Death Differ on 16 October 2026; matched the OnCo record for EIF4A1.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Cell Death Differ", "doi": "10.1038/s41418-026-01870-y", "records": [ { "id": "eif4a1", "kind": "target", "name": "EIF4A1", "url": "https://onco.cc/targets/eif4a1/" }, { "id": "ixazomib", "kind": "drug", "name": "Ixazomib", "url": "https://onco.cc/drugs/ixazomib/" }, { "id": "pabpc1", "kind": "target", "name": "PABPC1", "url": "https://onco.cc/targets/pabpc1/" } ] } }, { "id": "https://doi.org/10.1111/ans.71009#onco-edge-paper", "url": "https://doi.org/10.1111/ans.71009", "title": "Pancreatic Invasion in Distal Cholangiocarcinoma Is a Poor Prognostic Factor: A New Approach Integrating Tumor Depth of Invasion.", "content_text": "Published in ANZ J Surg on 16 October 2026; matched the OnCo record for Extrahepatic cholangiocarcinoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "ANZ J Surg", "doi": "10.1111/ans.71009", "records": [ { "id": "extrahepatic-cholangiocarcinoma", "kind": "cancer", "name": "Extrahepatic cholangiocarcinoma", "url": "https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/" } ] } }, { "id": "https://doi.org/10.1186/s13244-026-02434-x#onco-edge-paper", "url": "https://doi.org/10.1186/s13244-026-02434-x", "title": "Patient acceptance and experience with contrast-enhanced mammography in women with a personal history of breast cancer: findings from the COMBO trial.", "content_text": "Published in Insights Imaging on 16 October 2026; matched the OnCo record for Contrast-enhanced mammography.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Insights Imaging", "doi": "10.1186/s13244-026-02434-x", "records": [ { "id": "contrast-enhanced-mammography", "kind": "technology", "name": "Contrast-enhanced mammography", "url": "https://onco.cc/technologies/contrast-enhanced-mammography/" } ] } }, { "id": "https://doi.org/10.3892/or.2026.9212#onco-edge-paper", "url": "https://doi.org/10.3892/or.2026.9212", "title": "PBRM1 knockdown is associated with NRF2‑dependent ALDOA upregulation and metabolic reprogramming in HCCC‑9810 intrahepatic cholangiocarcinoma cells.", "content_text": "Published in Oncol Rep on 16 October 2026; matched the OnCo record for Ki-67.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Oncol Rep", "doi": "10.3892/or.2026.9212", "records": [ { "id": "mki67", "kind": "target", "name": "Ki-67", "url": "https://onco.cc/targets/mki67/" }, { "id": "pbrm1", "kind": "target", "name": "PBRM1", "url": "https://onco.cc/targets/pbrm1/" } ] } }, { "id": "https://doi.org/10.1515/jpem-2026-0379#onco-edge-paper", "url": "https://doi.org/10.1515/jpem-2026-0379", "title": "Pediatric prolactinoma-associated pituitary apoplexy presenting with acute visual loss: a case report, literature review, and management strategy.", "content_text": "Published in J Pediatr Endocrinol Metab on 16 October 2026; matched the OnCo record for Cabergoline.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Pediatr Endocrinol Metab", "doi": "10.1515/jpem-2026-0379", "records": [ { "id": "cabergoline", "kind": "drug", "name": "Cabergoline", "url": "https://onco.cc/drugs/cabergoline/" }, { "id": "lactotroph-pitnet", "kind": "cancer", "name": "Lactotroph pituitary neuroendocrine tumour", "url": "https://onco.cc/cancers/lactotroph-pitnet/" } ] } }, { "id": "https://doi.org/10.1097/spc.0000000000000832#onco-edge-paper", "url": "https://doi.org/10.1097/spc.0000000000000832", "title": "Persistent chemotherapy-induced alopecia: a scoping review.", "content_text": "Published in Curr Opin Support Palliat Care on 16 October 2026; matched the OnCo record for Scalp cooling.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Curr Opin Support Palliat Care", "doi": "10.1097/spc.0000000000000832", "records": [ { "id": "scalp-cooling", "kind": "technology", "name": "Scalp cooling", "url": "https://onco.cc/technologies/scalp-cooling/" } ] } }, { "id": "https://doi.org/10.1242/dmm.052907#onco-edge-paper", "url": "https://doi.org/10.1242/dmm.052907", "title": "Pharmacokinetics and efficacy of tank-water-administered dabrafenib, a BRAF inhibitor, in a zebrafish model of melanoma.", "content_text": "Published in Dis Model Mech on 16 October 2026; matched the OnCo record for BRAF V600-mutant melanoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Dis Model Mech", "doi": "10.1242/dmm.052907", "records": [ { "id": "braf-v600-melanoma", "kind": "cancer", "name": "BRAF V600-mutant melanoma", "url": "https://onco.cc/cancers/braf-v600-melanoma/" } ] } }, { "id": "https://doi.org/10.1200/po-26-00390#onco-edge-paper", "url": "https://doi.org/10.1200/po-26-00390", "title": "Plasma-Derived Genomic Instability Status and Rucaparib Outcomes in Metastatic Castration-Resistant Prostate Cancer: TRITON2.", "content_text": "Published in JCO Precis Oncol on 16 October 2026; matched the OnCo record for HRD & BRCA testing.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "JCO Precis Oncol", "doi": "10.1200/po-26-00390", "records": [ { "id": "hrd-testing", "kind": "technology", "name": "HRD & BRCA testing", "url": "https://onco.cc/technologies/hrd-testing/" }, { "id": "palb2", "kind": "target", "name": "PALB2", "url": "https://onco.cc/targets/palb2/" }, { "id": "rucaparib", "kind": "drug", "name": "Rucaparib", "url": "https://onco.cc/drugs/rucaparib/" } ] } }, { "id": "https://doi.org/10.1016/j.hoc.2026.09.012#onco-edge-paper", "url": "https://doi.org/10.1016/j.hoc.2026.09.012", "title": "Platelet Dysfunction in Liver and Kidney Disease.", "content_text": "Published in Hematol Oncol Clin North Am on 16 October 2026; matched the OnCo record for VWF.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Hematol Oncol Clin North Am", "doi": "10.1016/j.hoc.2026.09.012", "records": [ { "id": "vwf", "kind": "target", "name": "VWF", "url": "https://onco.cc/targets/vwf/" } ] } }, { "id": "https://doi.org/10.1212/cpj.0000000000200679#onco-edge-paper", "url": "https://doi.org/10.1212/cpj.0000000000200679", "title": "Practical Review of Role and Usage of Corticosteroids in Modern Neuro-Oncology Care.", "content_text": "Published in Neurol Clin Pract on 16 October 2026; matched the OnCo record for Anti-angiogenic therapy.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Neurol Clin Pract", "doi": "10.1212/cpj.0000000000200679", "records": [ { "id": "antiangiogenic", "kind": "technology", "name": "Anti-angiogenic therapy", "url": "https://onco.cc/technologies/antiangiogenic/" }, { "id": "bevacizumab-glioma", "kind": "drug", "name": "Bevacizumab", "url": "https://onco.cc/drugs/bevacizumab-glioma/" }, { "id": "bevacizumab", "kind": "drug", "name": "Bevacizumab", "url": "https://onco.cc/drugs/bevacizumab/" } ] } }, { "id": "https://doi.org/10.1016/j.compbiomed.2026.111995#onco-edge-paper", "url": "https://doi.org/10.1016/j.compbiomed.2026.111995", "title": "Prediction residuals in spatial transcriptomics reveal microenvironmental heterogeneity in cancer.", "content_text": "Published in Comput Biol Med on 16 October 2026; matched the OnCo record for Pathology & radiology foundation models.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Comput Biol Med", "doi": "10.1016/j.compbiomed.2026.111995", "records": [ { "id": "pathology-foundation-model", "kind": "technology", "name": "Pathology & radiology foundation models", "url": "https://onco.cc/technologies/pathology-foundation-model/" } ] } }, { "id": "https://doi.org/10.1093/neuonc/noag262#onco-edge-paper", "url": "https://doi.org/10.1093/neuonc/noag262", "title": "Prognostic Significance of Contrast Enhancement in Newly Diagnosed Grade 2 IDH-mutant Glioma.", "content_text": "Published in Neuro Oncol on 16 October 2026; matched the OnCo record for Vorasidenib.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Neuro Oncol", "doi": "10.1093/neuonc/noag262", "records": [ { "id": "vorasidenib", "kind": "drug", "name": "Vorasidenib", "url": "https://onco.cc/drugs/vorasidenib/" } ] } }, { "id": "https://doi.org/10.1016/j.urolonc.2026.09.018#onco-edge-paper", "url": "https://doi.org/10.1016/j.urolonc.2026.09.018", "title": "Project international Delphi consensus recommendations for perioperative management of inguinal lymphadenectomy in cancer patients.", "content_text": "Published in Urol Oncol on 16 October 2026; matched the OnCo record for Penile cancer.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Urol Oncol", "doi": "10.1016/j.urolonc.2026.09.018", "records": [ { "id": "penile", "kind": "cancer", "name": "Penile cancer", "url": "https://onco.cc/cancers/penile/" }, { "id": "vulvar", "kind": "cancer", "name": "Vulvar cancer", "url": "https://onco.cc/cancers/vulvar/" } ] } }, { "id": "https://doi.org/10.1111/bjh.70883#onco-edge-paper", "url": "https://doi.org/10.1111/bjh.70883", "title": "Prospective phase I study of nivolumab to promote graft-versus-tumour in relapsed or refractory haematological malignancy post allogeneic haematopoietic stem cell transplantation.", "content_text": "Published in Br J Haematol on 16 October 2026; matched the OnCo record for Acute lymphoblastic leukaemia.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Br J Haematol", "doi": "10.1111/bjh.70883", "records": [ { "id": "all-leukemia", "kind": "cancer", "name": "Acute lymphoblastic leukaemia", "url": "https://onco.cc/cancers/all-leukemia/" } ] } }, { "id": "https://doi.org/10.1016/j.urolonc.2026.09.010#onco-edge-paper", "url": "https://doi.org/10.1016/j.urolonc.2026.09.010", "title": "Prospectively collected functional vs. self-reported frailty measures and postoperative outcomes after radical cystectomy in older adults with bladder cancer.", "content_text": "Published in Urol Oncol on 16 October 2026; matched the OnCo record for Geriatric assessment.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Urol Oncol", "doi": "10.1016/j.urolonc.2026.09.010", "records": [ { "id": "geriatric-assessment", "kind": "technology", "name": "Geriatric assessment", "url": "https://onco.cc/technologies/geriatric-assessment/" } ] } }, { "id": "https://doi.org/10.1158/1078-0432.ccr-26-1824#onco-edge-paper", "url": "https://doi.org/10.1158/1078-0432.ccr-26-1824", "title": "Radiotherapy combined with serplulimab, and chemotherapy as first-line treatment for metastatic pancreatic adenocarcinoma: a multicenter, single-arm, phase II trial.", "content_text": "Published in Clin Cancer Res on 16 October 2026; matched the OnCo record for Serplulimab.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Clin Cancer Res", "doi": "10.1158/1078-0432.ccr-26-1824", "records": [ { "id": "serplulimab", "kind": "drug", "name": "Serplulimab", "url": "https://onco.cc/drugs/serplulimab/" } ] } }, { "id": "https://doi.org/10.1177/10499091261498828#onco-edge-paper", "url": "https://doi.org/10.1177/10499091261498828", "title": "Rapid-Onset Opioid-Induced Neurotoxicity During Morphine Therapy.", "content_text": "Published in Am J Hosp Palliat Care on 16 October 2026; matched the OnCo record for Cancer pain management.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Am J Hosp Palliat Care", "doi": "10.1177/10499091261498828", "records": [ { "id": "pain-management", "kind": "technology", "name": "Cancer pain management", "url": "https://onco.cc/technologies/pain-management/" } ] } }, { "id": "https://doi.org/10.3892/ijo.2026.5949#onco-edge-paper", "url": "https://doi.org/10.3892/ijo.2026.5949", "title": "Research progress of SPP1 in cancer regulation: Tumorigenesis, metastasis, tumor microenvironment, immunity and therapeutic targets (Review).", "content_text": "Published in Int J Oncol on 16 October 2026; matched the OnCo record for CD44.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Int J Oncol", "doi": "10.3892/ijo.2026.5949", "records": [ { "id": "cd44", "kind": "target", "name": "CD44", "url": "https://onco.cc/targets/cd44/" } ] } }, { "id": "https://doi.org/10.1016/j.jaad.2026.10.030#onco-edge-paper", "url": "https://doi.org/10.1016/j.jaad.2026.10.030", "title": "Response to De Giorgi et al., \"Surgical delay in early-stage vulvar melanoma: caution in defining a causal threshold.\"", "content_text": "Published in J Am Acad Dermatol on 16 October 2026; matched the OnCo record for Vulvar melanoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Am Acad Dermatol", "doi": "10.1016/j.jaad.2026.10.030", "records": [ { "id": "vulvar-melanoma", "kind": "cancer", "name": "Vulvar melanoma", "url": "https://onco.cc/cancers/vulvar-melanoma/" } ] } }, { "id": "https://doi.org/10.1017/s1047951126124512#onco-edge-paper", "url": "https://doi.org/10.1017/s1047951126124512", "title": "Reversible atrioventricular block associated with transdermal fentanyl use: a paediatric case with non-Hodgkin lymphoma.", "content_text": "Published in Cardiol Young on 16 October 2026; matched the OnCo record for Fentanyl.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Cardiol Young", "doi": "10.1017/s1047951126124512", "records": [ { "id": "fentanyl", "kind": "drug", "name": "Fentanyl", "url": "https://onco.cc/drugs/fentanyl/" } ] } }, { "id": "https://doi.org/10.1371/journal.pgen.1012340#onco-edge-paper", "url": "https://doi.org/10.1371/journal.pgen.1012340", "title": "Revisiting the impact of synthetic ORF sequences on engineered LINE-1 retrotransposition.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched NCKIPSD.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.1371/journal.pgen.1012340", "records": [ { "id": "nckipsd", "kind": "target", "name": "NCKIPSD", "url": "https://onco.cc/targets/nckipsd/" } ] } }, { "id": "https://doi.org/10.1007/s11010-026-05782-w#onco-edge-paper", "url": "https://doi.org/10.1007/s11010-026-05782-w", "title": "ROCK2 regulates a stress-responsive transcriptional state and calcium signaling in renal cell carcinoma.", "content_text": "Published in Mol Cell Biochem on 16 October 2026; matched the OnCo record for CREB1.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Cell Biochem", "doi": "10.1007/s11010-026-05782-w", "records": [ { "id": "creb1", "kind": "target", "name": "CREB1", "url": "https://onco.cc/targets/creb1/" } ] } }, { "id": "https://doi.org/10.1039/d6cc05604k#onco-edge-paper", "url": "https://doi.org/10.1039/d6cc05604k", "title": "Self-assembled floxuridine prodrug nanovesicles for synergistic drug delivery and gene silencing.", "content_text": "Published in Chem Commun (Camb) on 16 October 2026; matched the OnCo record for Floxuridine.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Chem Commun (Camb)", "doi": "10.1039/d6cc05604k", "records": [ { "id": "floxuridine", "kind": "drug", "name": "Floxuridine", "url": "https://onco.cc/drugs/floxuridine/" } ] } }, { "id": "https://doi.org/10.3390/cancers18203354#onco-edge-paper", "url": "https://doi.org/10.3390/cancers18203354", "title": "Sex Hormone Estrone Sulfate Serendipitously Downregulates Intercellular Tunneling Nanotube Conduits, EMT, and Migration in Breast and Pancreatic Cancer Cells.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched HER2, Estrogen receptor and JUN.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.3390/cancers18203354", "records": [ { "id": "her2", "kind": "target", "name": "HER2", "url": "https://onco.cc/targets/her2/" }, { "id": "estrogen-receptor", "kind": "target", "name": "Estrogen receptor", "url": "https://onco.cc/targets/estrogen-receptor/" }, { "id": "jun", "kind": "target", "name": "JUN", "url": "https://onco.cc/targets/jun/" }, { "id": "egf", "kind": "target", "name": "EGF", "url": "https://onco.cc/targets/egf/" }, { "id": "fos", "kind": "target", "name": "FOS", "url": "https://onco.cc/targets/fos/" }, { "id": "fosb", "kind": "target", "name": "FOSB", "url": "https://onco.cc/targets/fosb/" } ] } }, { "id": "https://doi.org/10.3892/ijmm.2026.6013#onco-edge-paper", "url": "https://doi.org/10.3892/ijmm.2026.6013", "title": "Six3 promoting the migration and neural differentiation of BMSCs via Btg2‑mediated Akt signaling pathway activation: A therapeutic strategy for stroke.", "content_text": "Published in Int J Mol Med on 16 October 2026; matched the OnCo record for BTG2.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Int J Mol Med", "doi": "10.3892/ijmm.2026.6013", "records": [ { "id": "btg2", "kind": "target", "name": "BTG2", "url": "https://onco.cc/targets/btg2/" } ] } }, { "id": "https://doi.org/10.1007/s12105-026-01975-3#onco-edge-paper", "url": "https://doi.org/10.1007/s12105-026-01975-3", "title": "SOX10 Expression in Primary Salivary Gland Tumors: A Meta-Analysis.", "content_text": "Published in Head Neck Pathol on 16 October 2026; matched the OnCo record for BioEmu.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Head Neck Pathol", "doi": "10.1007/s12105-026-01975-3", "records": [ { "id": "bioemu", "kind": "technology", "name": "BioEmu", "url": "https://onco.cc/technologies/bioemu/" } ] } }, { "id": "https://doi.org/10.3171/2026.5.jns252620#onco-edge-paper", "url": "https://doi.org/10.3171/2026.5.jns252620", "title": "Spatial localization patterns in MRI-negative Cushing disease: a comparative pituitary heat map analysis.", "content_text": "Published in J Neurosurg on 16 October 2026; matched the OnCo record for CD96.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Neurosurg", "doi": "10.3171/2026.5.jns252620", "records": [ { "id": "cd96", "kind": "target", "name": "CD96", "url": "https://onco.cc/targets/cd96/" } ] } }, { "id": "https://doi.org/10.1126/sciimmunol.aed4832#onco-edge-paper", "url": "https://doi.org/10.1126/sciimmunol.aed4832", "title": "STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells.", "content_text": "Published in Sci Immunol on 16 October 2026; matched the OnCo record for MYB.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Sci Immunol", "doi": "10.1126/sciimmunol.aed4832", "records": [ { "id": "myb", "kind": "target", "name": "MYB", "url": "https://onco.cc/targets/myb/" }, { "id": "mybl1", "kind": "target", "name": "MYBL1", "url": "https://onco.cc/targets/mybl1/" }, { "id": "prdm1", "kind": "target", "name": "PRDM1", "url": "https://onco.cc/targets/prdm1/" } ] } }, { "id": "https://doi.org/10.1186/s43556-026-00598-y#onco-edge-paper", "url": "https://doi.org/10.1186/s43556-026-00598-y", "title": "Synthetic Notch CD123 and CLL1 chimeric antigen receptor T-cells (CAR-T) target acute myeloid leukemia and reduce off-tumor effects associated with CLL1 CAR-T cells.", "content_text": "Published in Mol Biomed on 16 October 2026; matched the OnCo record for CD123.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Biomed", "doi": "10.1186/s43556-026-00598-y", "records": [ { "id": "cd123", "kind": "target", "name": "CD123", "url": "https://onco.cc/targets/cd123/" } ] } }, { "id": "https://doi.org/10.3390/ijms27209183#onco-edge-paper", "url": "https://doi.org/10.3390/ijms27209183", "title": "Targeting of Immune Cells by Human Adenoviruses: CD46 Receptor Density Influences Entry of Chimaeric Ad5F35 into Natural Killer Cells.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched TNFRSF10B.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.3390/ijms27209183", "records": [ { "id": "tnfrsf10b", "kind": "target", "name": "TNFRSF10B", "url": "https://onco.cc/targets/tnfrsf10b/" } ] } }, { "id": "https://doi.org/10.1016/j.ymthe.2026.10.016#onco-edge-paper", "url": "https://doi.org/10.1016/j.ymthe.2026.10.016", "title": "The allogeneic eDN70(-) CAR-T Cells Without TCR or MHC Editing Exhibit Enhanced Persistence and Function.", "content_text": "Published in Mol Ther on 16 October 2026; matched the OnCo record for Allogeneic (off-the-shelf) cell therapy.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Ther", "doi": "10.1016/j.ymthe.2026.10.016", "records": [ { "id": "allogeneic-cell-therapy", "kind": "technology", "name": "Allogeneic (off-the-shelf) cell therapy", "url": "https://onco.cc/technologies/allogeneic-cell-therapy/" }, { "id": "cd70", "kind": "target", "name": "CD70", "url": "https://onco.cc/targets/cd70/" } ] } }, { "id": "https://doi.org/10.1038/s41467-026-77900-7#onco-edge-paper", "url": "https://doi.org/10.1038/s41467-026-77900-7", "title": "The molecular heterogeneity and clinical impact of genomic driver alterations in prostate cancer.", "content_text": "Published in Nat Commun on 16 October 2026; matched the OnCo record for MDM4.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Nat Commun", "doi": "10.1038/s41467-026-77900-7", "records": [ { "id": "mdm4", "kind": "target", "name": "MDM4", "url": "https://onco.cc/targets/mdm4/" } ] } }, { "id": "https://doi.org/10.1261/rna.081099.126#onco-edge-paper", "url": "https://doi.org/10.1261/rna.081099.126", "title": "The moonlighting functions of SEC13 in nonsense-mediated mRNA decay and the regulation of ER stress.", "content_text": "Published on 16 October 2026 after first appearing as a preprint; matched RNA sequencing & expression profiling and Single-cell & spatial profiling.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "doi": "10.1261/rna.081099.126", "records": [ { "id": "rna-seq", "kind": "technology", "name": "RNA sequencing & expression profiling", "url": "https://onco.cc/technologies/rna-seq/" }, { "id": "single-cell-spatial", "kind": "technology", "name": "Single-cell & spatial profiling", "url": "https://onco.cc/technologies/single-cell-spatial/" } ] } }, { "id": "https://doi.org/10.1038/s41409-026-03068-9#onco-edge-paper", "url": "https://doi.org/10.1038/s41409-026-03068-9", "title": "The prognostic impact of CEBPA mutation in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation.", "content_text": "Published in Bone Marrow Transplant on 16 October 2026; matched the OnCo record for GATA2.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Bone Marrow Transplant", "doi": "10.1038/s41409-026-03068-9", "records": [ { "id": "gata2", "kind": "target", "name": "GATA2", "url": "https://onco.cc/targets/gata2/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aeh3827#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aeh3827", "title": "TONSL/TONSOKU binding to histone H3.1 is required for DNA repair.", "content_text": "Published in Sci Adv on 16 October 2026; matched the OnCo record for Histone H3.3.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Sci Adv", "doi": "10.1126/sciadv.aeh3827", "records": [ { "id": "h3-3a", "kind": "target", "name": "Histone H3.3", "url": "https://onco.cc/targets/h3-3a/" }, { "id": "h3-3b", "kind": "target", "name": "H3-3B", "url": "https://onco.cc/targets/h3-3b/" }, { "id": "h3c2", "kind": "target", "name": "H3C2", "url": "https://onco.cc/targets/h3c2/" }, { "id": "h3c4", "kind": "target", "name": "H3C4", "url": "https://onco.cc/targets/h3c4/" }, { "id": "tpr", "kind": "target", "name": "TPR", "url": "https://onco.cc/targets/tpr/" } ] } }, { "id": "https://doi.org/10.1007/s11033-026-12928-y#onco-edge-paper", "url": "https://doi.org/10.1007/s11033-026-12928-y", "title": "Trans-vaccenic acid reduces HT-29 colorectal cancer cell viability and is associated with changes in apoptosis-, lipid metabolism-, and survival-related gene and candidate miRNA expression.", "content_text": "Published in Mol Biol Rep on 16 October 2026; matched the OnCo record for CASP8.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Biol Rep", "doi": "10.1007/s11033-026-12928-y", "records": [ { "id": "casp8", "kind": "target", "name": "CASP8", "url": "https://onco.cc/targets/casp8/" } ] } }, { "id": "https://doi.org/10.1093/neuonc/noag261#onco-edge-paper", "url": "https://doi.org/10.1093/neuonc/noag261", "title": "Unilateral vs Bilateral Hippocampal Avoidance During WBRT With Memantine for Brain Metastases: A Randomized Single-Blind Phase 2 Clinical Trial.", "content_text": "Published in Neuro Oncol on 16 October 2026; matched the OnCo record for Memantine.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Neuro Oncol", "doi": "10.1093/neuonc/noag261", "records": [ { "id": "memantine", "kind": "drug", "name": "Memantine", "url": "https://onco.cc/drugs/memantine/" } ] } }, { "id": "https://doi.org/10.1038/s41431-026-02255-y#onco-edge-paper", "url": "https://doi.org/10.1038/s41431-026-02255-y", "title": "Uterine leiomyomas in HLRCC: a scoping review of presentation, histopathology, treatment patterns, and reproductive implications.", "content_text": "Published in Eur J Hum Genet on 16 October 2026; matched the OnCo record for Fumarate hydratase-deficient renal cell carcinoma.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Eur J Hum Genet", "doi": "10.1038/s41431-026-02255-y", "records": [ { "id": "fh-deficient-renal-cell-carcinoma", "kind": "cancer", "name": "Fumarate hydratase-deficient renal cell carcinoma", "url": "https://onco.cc/cancers/fh-deficient-renal-cell-carcinoma/" }, { "id": "fh", "kind": "target", "name": "FH", "url": "https://onco.cc/targets/fh/" } ] } }, { "id": "https://doi.org/10.1016/j.jpag.2026.10.005#onco-edge-paper", "url": "https://doi.org/10.1016/j.jpag.2026.10.005", "title": "Virilizing Juvenile Granulosa Cell Tumor in a Prepubertal Girl with Bilateral Inguinal Hernias: A Case Report.", "content_text": "Published in J Pediatr Adolesc Gynecol on 16 October 2026; matched the OnCo record for MUC16.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "J Pediatr Adolesc Gynecol", "doi": "10.1016/j.jpag.2026.10.005", "records": [ { "id": "muc16", "kind": "target", "name": "MUC16", "url": "https://onco.cc/targets/muc16/" }, { "id": "serum-tumour-markers", "kind": "technology", "name": "Serum tumour markers: proper use and misuse", "url": "https://onco.cc/technologies/serum-tumour-markers/" } ] } }, { "id": "https://doi.org/10.1093/oncolo/oyag404#onco-edge-paper", "url": "https://doi.org/10.1093/oncolo/oyag404", "title": "Whole Genome Sequencing-based tumor-informed circulating tumor DNA monitoring for early detection of recurrence in patients with solid tumors.", "content_text": "Published in Oncologist on 16 October 2026; matched the OnCo record for Signatera.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Oncologist", "doi": "10.1093/oncolo/oyag404", "records": [ { "id": "signatera", "kind": "drug", "name": "Signatera", "url": "https://onco.cc/drugs/signatera/" } ] } }, { "id": "https://doi.org/10.1097/pas.0000000000002630#onco-edge-paper", "url": "https://doi.org/10.1097/pas.0000000000002630", "title": "Whole-Exome and Whole-Genome Sequencing Identifies Driver CTNNB1 Mutations in Ossifying Renal Tumor of Infancy.", "content_text": "Published in Am J Surg Pathol on 16 October 2026; matched the OnCo record for AXIN1.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Am J Surg Pathol", "doi": "10.1097/pas.0000000000002630", "records": [ { "id": "axin1", "kind": "target", "name": "AXIN1", "url": "https://onco.cc/targets/axin1/" }, { "id": "axin2", "kind": "target", "name": "AXIN2", "url": "https://onco.cc/targets/axin2/" }, { "id": "bmpr1a", "kind": "target", "name": "BMPR1A", "url": "https://onco.cc/targets/bmpr1a/" }, { "id": "etv6", "kind": "target", "name": "ETV6", "url": "https://onco.cc/targets/etv6/" }, { "id": "pax8", "kind": "target", "name": "PAX8", "url": "https://onco.cc/targets/pax8/" } ] } }, { "id": "https://doi.org/10.1126/sciadv.aeh9198#onco-edge-paper", "url": "https://doi.org/10.1126/sciadv.aeh9198", "title": "WNK1 links ionic signals to microtubule dynamics to control pyrin inflammasome assembly.", "content_text": "Published in Sci Adv on 16 October 2026; matched the OnCo record for WNK1.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Sci Adv", "doi": "10.1126/sciadv.aeh9198", "records": [ { "id": "wnk1", "kind": "target", "name": "WNK1", "url": "https://onco.cc/targets/wnk1/" } ] } }, { "id": "https://doi.org/10.3892/mmr.2026.14040#onco-edge-paper", "url": "https://doi.org/10.3892/mmr.2026.14040", "title": "ΔNp63α‑mediated regulation of tumor‑associated genes and pathways in hepatocellular carcinoma progression.", "content_text": "Published in Mol Med Rep on 16 October 2026; matched the OnCo record for CTCF.", "date_published": "2026-10-16T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-16", "precision": "day", "venue": "Mol Med Rep", "doi": "10.3892/mmr.2026.14040", "records": [ { "id": "ctcf", "kind": "target", "name": "CTCF", "url": "https://onco.cc/targets/ctcf/" } ] } }, { "id": "https://doi.org/10.1038/s41591-026-04736-5#onco-edge-paper", "url": "https://doi.org/10.1038/s41591-026-04736-5", "title": "Addendum: Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.", "content_text": "Published in Nat Med on 9 October 2026; matched the OnCo record for GREM1.", "date_published": "2026-10-09T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-09", "precision": "day", "venue": "Nat Med", "doi": "10.1038/s41591-026-04736-5", "records": [ { "id": "grem1", "kind": "target", "name": "GREM1", "url": "https://onco.cc/targets/grem1/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pirtobrutinib-previously-untreated-chronic-lymphocytic-leukemia-or-small-lymphocytic#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-pirtobrutinib-previously-untreated-chronic-lymphocytic-leukemia-or-small-lymphocytic", "title": "FDA approves pirtobrutinib for previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma", "content_text": "On October 2, 2026, the Food and Drug Administration approved pirtobrutinib (Jaypirca, Eli Lilly and Company) for adult patients with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) with no known 17p deletion.", "date_published": "2026-10-02T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-10-02", "precision": "day", "venue": "FDA", "records": [ { "id": "pirtobrutinib", "kind": "drug", "name": "Pirtobrutinib", "url": "https://onco.cc/drugs/pirtobrutinib/" }, { "id": "non-hodgkin-lymphoma", "kind": "cancer", "name": "Non-Hodgkin lymphoma", "url": "https://onco.cc/cancers/non-hodgkin-lymphoma/" }, { "id": "adult-t-cell-leukaemia-lymphoma", "kind": "cancer", "name": "Adult T-cell leukaemia/lymphoma", "url": "https://onco.cc/cancers/adult-t-cell-leukaemia-lymphoma/" }, { "id": "leukaemia", "kind": "cancer", "name": "Leukaemia", "url": "https://onco.cc/cancers/leukaemia/" } ] } }, { "id": "https://doi.org/10.3760/cma.j.cn112140-20260618-00495#onco-edge-paper", "url": "https://doi.org/10.3760/cma.j.cn112140-20260618-00495", "title": "[Analysis of clinical characteristics and prognosis of non-rhabdomyosarcoma soft tissue sarcomas in 72 children].", "content_text": "Published in Zhonghua Er Ke Za Zhi on 15 October 2026; matched the OnCo record for Synovial sarcoma.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Zhonghua Er Ke Za Zhi", "doi": "10.3760/cma.j.cn112140-20260618-00495", "records": [ { "id": "synovial-sarcoma", "kind": "cancer", "name": "Synovial sarcoma", "url": "https://onco.cc/cancers/synovial-sarcoma/" } ] } }, { "id": "https://doi.org/10.3760/cma.j.cn112140-20260623-00502#onco-edge-paper", "url": "https://doi.org/10.3760/cma.j.cn112140-20260623-00502", "title": "[Clinical analysis of 21 children with Xp11.2 translocation renal cell carcinoma].", "content_text": "Published in Zhonghua Er Ke Za Zhi on 15 October 2026; matched the OnCo record for TFE3-rearranged (translocation) renal cell carcinoma.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Zhonghua Er Ke Za Zhi", "doi": "10.3760/cma.j.cn112140-20260623-00502", "records": [ { "id": "tfe3-rearranged-renal-cell-carcinoma", "kind": "cancer", "name": "TFE3-rearranged (translocation) renal cell carcinoma", "url": "https://onco.cc/cancers/tfe3-rearranged-renal-cell-carcinoma/" } ] } }, { "id": "https://doi.org/10.3760/cma.j.cn112140-20260828-00670#onco-edge-paper", "url": "https://doi.org/10.3760/cma.j.cn112140-20260828-00670", "title": "[Clinical analysis of modified Chinese Children Leukemia Group-Acute Myeloid Leukemia 2019 regimen in treating pediatric acute myeloid leukemia].", "content_text": "Published in Zhonghua Er Ke Za Zhi on 15 October 2026; matched the OnCo record for Acute promyelocytic leukaemia.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Zhonghua Er Ke Za Zhi", "doi": "10.3760/cma.j.cn112140-20260828-00670", "records": [ { "id": "apl", "kind": "cancer", "name": "Acute promyelocytic leukaemia", "url": "https://onco.cc/cancers/apl/" }, { "id": "cladribine", "kind": "drug", "name": "Cladribine", "url": "https://onco.cc/drugs/cladribine/" } ] } }, { "id": "https://doi.org/10.1007/s00292-026-01601-7#onco-edge-paper", "url": "https://doi.org/10.1007/s00292-026-01601-7", "title": "[Melanocytomas : Intermediate melanocytic neoplasms with distinct morphology and molecular background].", "content_text": "Published in Pathologie (Heidelb) on 15 October 2026; matched the OnCo record for BIM.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Pathologie (Heidelb)", "doi": "10.1007/s00292-026-01601-7", "records": [ { "id": "bim", "kind": "target", "name": "BIM", "url": "https://onco.cc/targets/bim/" }, { "id": "mek", "kind": "target", "name": "MEK1/2", "url": "https://onco.cc/targets/mek/" } ] } }, { "id": "https://doi.org/10.1007/s00106-026-01822-5#onco-edge-paper", "url": "https://doi.org/10.1007/s00106-026-01822-5", "title": "[Nonimmunological systemic therapies in head and neck cancer : Cytotoxic, targeted, EGFR-directed, and supportive approaches at ASCO 2026].", "content_text": "Published in HNO on 15 October 2026; matched the OnCo record for Amivantamab.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "HNO", "doi": "10.1007/s00106-026-01822-5", "records": [ { "id": "amivantamab", "kind": "drug", "name": "Amivantamab", "url": "https://onco.cc/drugs/amivantamab/" }, { "id": "nimotuzumab", "kind": "drug", "name": "Nimotuzumab", "url": "https://onco.cc/drugs/nimotuzumab/" } ] } }, { "id": "https://doi.org/10.3760/cma.j.cn112140-20260616-00486#onco-edge-paper", "url": "https://doi.org/10.3760/cma.j.cn112140-20260616-00486", "title": "[Pathogenesis and treatment advances of CBFA2T3::GLIS2 fusion gene-driven acute megakaryoblastic leukemia].", "content_text": "Published in Zhonghua Er Ke Za Zhi on 15 October 2026; matched the OnCo record for CBFA2T3.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Zhonghua Er Ke Za Zhi", "doi": "10.3760/cma.j.cn112140-20260616-00486", "records": [ { "id": "cbfa2t3", "kind": "target", "name": "CBFA2T3", "url": "https://onco.cc/targets/cbfa2t3/" } ] } }, { "id": "https://doi.org/10.1016/j.bulcan.2026.08.009#onco-edge-paper", "url": "https://doi.org/10.1016/j.bulcan.2026.08.009", "title": "[Recommendations of the Groupe Francophone des Myélodysplasies (GFM) - Diagnostic approach and management of myelodysplastic syndromes, chronic myelomonocytic leukemias, and VEXAS syndrome].", "content_text": "Published in Bull Cancer on 15 October 2026; matched the OnCo record for Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Bull Cancer", "doi": "10.1016/j.bulcan.2026.08.009", "records": [ { "id": "cmml", "kind": "cancer", "name": "Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms", "url": "https://onco.cc/cancers/cmml/" }, { "id": "imetelstat", "kind": "drug", "name": "Imetelstat", "url": "https://onco.cc/drugs/imetelstat/" }, { "id": "luspatercept", "kind": "drug", "name": "Luspatercept", "url": "https://onco.cc/drugs/luspatercept/" } ] } }, { "id": "https://doi.org/10.1002/hem3.70500#onco-edge-paper", "url": "https://doi.org/10.1002/hem3.70500", "title": "EZH2 mutation status predicts inferior outcomes after bendamustine-based immunochemotherapy in frontline follicular lymphoma: A GELTAMO multicenter validation study.", "content_text": "Published in Hemasphere on 15 October 2026; matched the OnCo record for Bendamustine.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Hemasphere", "doi": "10.1002/hem3.70500", "records": [ { "id": "bendamustine", "kind": "drug", "name": "Bendamustine", "url": "https://onco.cc/drugs/bendamustine/" } ] } }, { "id": "https://doi.org/10.1016/j.bioorg.2026.110662#onco-edge-paper", "url": "https://doi.org/10.1016/j.bioorg.2026.110662", "title": "2-Azabicyclo[3.2.1]octane-based ALK inhibitors inspired by aconitine scaffold remodeling: design, synthesis, and biological evaluation.", "content_text": "Published in Bioorg Chem on 15 October 2026; matched the OnCo record for Ceritinib.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Bioorg Chem", "doi": "10.1016/j.bioorg.2026.110662", "records": [ { "id": "ceritinib", "kind": "drug", "name": "Ceritinib", "url": "https://onco.cc/drugs/ceritinib/" } ] } }, { "id": "https://doi.org/10.1038/s41418-026-01891-7#onco-edge-paper", "url": "https://doi.org/10.1038/s41418-026-01891-7", "title": "A chemical-genetic system for calreticulin exposure on cancer cells reveals immune-dependent antitumor effects.", "content_text": "Published in Cell Death Differ on 15 October 2026; matched the OnCo record for POLD1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cell Death Differ", "doi": "10.1038/s41418-026-01891-7", "records": [ { "id": "pold1", "kind": "target", "name": "POLD1", "url": "https://onco.cc/targets/pold1/" } ] } }, { "id": "https://doi.org/10.20945/2359-4292-2026-0119#onco-edge-paper", "url": "https://doi.org/10.20945/2359-4292-2026-0119", "title": "A combined genetic and bioinformatic analysis implicates the CDKN1A rs1059234 variant in differentiated thyroid carcinoma susceptibility.", "content_text": "Published in Arch Endocrinol Metab on 15 October 2026; matched the OnCo record for CDKN1B.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Arch Endocrinol Metab", "doi": "10.20945/2359-4292-2026-0119", "records": [ { "id": "cdkn1b", "kind": "target", "name": "CDKN1B", "url": "https://onco.cc/targets/cdkn1b/" } ] } }, { "id": "https://doi.org/10.1093/ejendo/lvag188#onco-edge-paper", "url": "https://doi.org/10.1093/ejendo/lvag188", "title": "A Genetic Risk Approach to Differential Diagnosis of Type 1 Diabetes and Risk Stratification in the Spanish Population.", "content_text": "Published in Eur J Endocrinol on 15 October 2026; matched the OnCo record for CD40.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Eur J Endocrinol", "doi": "10.1093/ejendo/lvag188", "records": [ { "id": "cd40", "kind": "target", "name": "CD40", "url": "https://onco.cc/targets/cd40/" }, { "id": "psip1", "kind": "target", "name": "PSIP1", "url": "https://onco.cc/targets/psip1/" } ] } }, { "id": "https://doi.org/10.1007/s12029-026-01608-6#onco-edge-paper", "url": "https://doi.org/10.1007/s12029-026-01608-6", "title": "A Meta-Analysis on Outcomes of Zanidatamab Plus Chemotherapy in Patients with Advanced HER2-positive Gastroesophageal Adenocarcinoma.", "content_text": "Published in J Gastrointest Cancer on 15 October 2026; matched the OnCo record for Tislelizumab.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Gastrointest Cancer", "doi": "10.1007/s12029-026-01608-6", "records": [ { "id": "tislelizumab", "kind": "drug", "name": "Tislelizumab", "url": "https://onco.cc/drugs/tislelizumab/" }, { "id": "zanidatamab", "kind": "drug", "name": "Zanidatamab", "url": "https://onco.cc/drugs/zanidatamab/" } ] } }, { "id": "https://doi.org/10.1002/smll.76306#onco-edge-paper", "url": "https://doi.org/10.1002/smll.76306", "title": "A Nanodelivery Platform Harnessing Synthetic Lethality and Efferocytosis Inhibition for Synergistically Enhanced Immunotherapy of Triple-Negative Breast Cancer.", "content_text": "Published in Small on 15 October 2026; matched the OnCo record for PLK1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Small", "doi": "10.1002/smll.76306", "records": [ { "id": "plk1", "kind": "target", "name": "PLK1", "url": "https://onco.cc/targets/plk1/" } ] } }, { "id": "https://doi.org/10.1016/j.jtct.2026.10.020#onco-edge-paper", "url": "https://doi.org/10.1016/j.jtct.2026.10.020", "title": "A Pilot Study of Condensed Busulfan, Melphalan, and Fludarabine Myeloablative Conditioning in Ex Vivo CD34-Selected Allogeneic Hematopoietic Cell Transplantation.", "content_text": "Published in Transplant Cell Ther on 15 October 2026; matched the OnCo record for Busulfan.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Transplant Cell Ther", "doi": "10.1016/j.jtct.2026.10.020", "records": [ { "id": "busulfan", "kind": "drug", "name": "Busulfan", "url": "https://onco.cc/drugs/busulfan/" }, { "id": "melphalan", "kind": "drug", "name": "Melphalan", "url": "https://onco.cc/drugs/melphalan/" } ] } }, { "id": "https://doi.org/10.3390/curroncol33100621#onco-edge-paper", "url": "https://doi.org/10.3390/curroncol33100621", "title": "A Remotely Delivered Exercise-Based Rehabilitation Program for Patients with Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN): A Phase I Feasibility Trial.", "content_text": "Published in Curr Oncol on 15 October 2026; found by the roadmap watch for EX-CIPN: virtual exercise-based rehabilitation for persistent chemotherapy nerve damage.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Curr Oncol", "doi": "10.3390/curroncol33100621", "records": [ { "id": "rejuv-trial-ex-cipn", "kind": "trial", "name": "EX-CIPN: virtual exercise-based rehabilitation for persistent chemotherapy nerve damage", "url": "https://onco.cc/trials/rejuv-trial-ex-cipn/" }, { "id": "rejuvenation-roadmap", "kind": "roadmap", "name": "Recovery and rejuvenation roadmap: cure is not enough → survivorship gets a name → the cohorts that measured the cost → exercise proven as treatment → biological ageing measured and sold → repair, if anyone funds it", "url": "https://onco.cc/roadmaps/rejuvenation-roadmap/" } ] } }, { "id": "https://doi.org/10.1080/14737140.2026.2749345#onco-edge-paper", "url": "https://doi.org/10.1080/14737140.2026.2749345", "title": "Apalutamide in prostate cancer: clinical evidence, disease modification hypothesis, and emerging treatment de‑intensification strategies.", "content_text": "Published in Expert Rev Anticancer Ther on 15 October 2026; matched the OnCo record for Apalutamide.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Expert Rev Anticancer Ther", "doi": "10.1080/14737140.2026.2749345", "records": [ { "id": "apalutamide", "kind": "drug", "name": "Apalutamide", "url": "https://onco.cc/drugs/apalutamide/" } ] } }, { "id": "https://doi.org/10.1016/j.jaccao.2026.08.007#onco-edge-paper", "url": "https://doi.org/10.1016/j.jaccao.2026.08.007", "title": "Association of Life's Essential 8 With Clonal Hematopoiesis and Coronary Artery Disease.", "content_text": "Published in JACC CardioOncol on 15 October 2026; matched the OnCo record for ASXL1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "JACC CardioOncol", "doi": "10.1016/j.jaccao.2026.08.007", "records": [ { "id": "asxl1", "kind": "target", "name": "ASXL1", "url": "https://onco.cc/targets/asxl1/" } ] } }, { "id": "https://doi.org/10.12659/ajcr.953658#onco-edge-paper", "url": "https://doi.org/10.12659/ajcr.953658", "title": "Behind the Sella: A Rare Case of Pituicytoma Mimicking a Pituitary Adenoma.", "content_text": "Published in Am J Case Rep on 15 October 2026; matched the OnCo record for Lactotroph pituitary neuroendocrine tumour.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Am J Case Rep", "doi": "10.12659/ajcr.953658", "records": [ { "id": "lactotroph-pitnet", "kind": "cancer", "name": "Lactotroph pituitary neuroendocrine tumour", "url": "https://onco.cc/cancers/lactotroph-pitnet/" } ] } }, { "id": "https://doi.org/10.1097/mph.0000000000003304#onco-edge-paper", "url": "https://doi.org/10.1097/mph.0000000000003304", "title": "Beyond Reirradiation: Third-Course Radiation Therapy in Recurrent Diffuse Intrinsic Pontine Glioma-Case Series and Literature Review.", "content_text": "Published in J Pediatr Hematol Oncol on 15 October 2026; matched the OnCo record for Diffuse midline glioma, H3 K27-altered.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Pediatr Hematol Oncol", "doi": "10.1097/mph.0000000000003304", "records": [ { "id": "dipg-dmg", "kind": "cancer", "name": "Diffuse midline glioma, H3 K27-altered", "url": "https://onco.cc/cancers/dipg-dmg/" } ] } }, { "id": "https://doi.org/10.1002/mco2.71058#onco-edge-paper", "url": "https://doi.org/10.1002/mco2.71058", "title": "Bispecific NK-Cell Engager Targeting TP53 Mutation Through Integration of a TCR-mimic Antibody.", "content_text": "Published in MedComm (2020) on 15 October 2026; matched the OnCo record for NK cell engagers.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "MedComm (2020)", "doi": "10.1002/mco2.71058", "records": [ { "id": "nk-cell-engagers", "kind": "technology", "name": "NK cell engagers", "url": "https://onco.cc/technologies/nk-cell-engagers/" } ] } }, { "id": "https://doi.org/10.2967/jnumed.126.272351#onco-edge-paper", "url": "https://doi.org/10.2967/jnumed.126.272351", "title": "Brain-Specific Quantification of Somatostatin Receptor Expression: SUV<sub>max</sub> and SUVR<sub>sss</sub> as Quantitative Correlates of the Krenning Score in Meningioma.", "content_text": "Published in J Nucl Med on 15 October 2026; matched the OnCo record for Somatostatin analogues.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Nucl Med", "doi": "10.2967/jnumed.126.272351", "records": [ { "id": "octreotide-lanreotide", "kind": "drug", "name": "Somatostatin analogues", "url": "https://onco.cc/drugs/octreotide-lanreotide/" }, { "id": "prrt", "kind": "technology", "name": "Peptide receptor radionuclide therapy", "url": "https://onco.cc/technologies/prrt/" } ] } }, { "id": "https://doi.org/10.2169/internalmedicine.8150-26#onco-edge-paper", "url": "https://doi.org/10.2169/internalmedicine.8150-26", "title": "Calcified Pleural Dissemination and Malignant Pleural Effusion in Dedifferentiated Chondrosarcoma: A Case Report with an Institutional Review.", "content_text": "Published in Intern Med on 15 October 2026; matched the OnCo record for Chondrosarcoma.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Intern Med", "doi": "10.2169/internalmedicine.8150-26", "records": [ { "id": "chondrosarcoma", "kind": "cancer", "name": "Chondrosarcoma", "url": "https://onco.cc/cancers/chondrosarcoma/" } ] } }, { "id": "https://doi.org/10.1111/1754-9485.70209#onco-edge-paper", "url": "https://doi.org/10.1111/1754-9485.70209", "title": "Can Simple MRI Characteristics Predict Molecular Subgroups in Paediatric Medulloblastoma?", "content_text": "Published in J Med Imaging Radiat Oncol on 15 October 2026; matched the OnCo record for Group 3 and group 4 medulloblastoma.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Med Imaging Radiat Oncol", "doi": "10.1111/1754-9485.70209", "records": [ { "id": "medulloblastoma-group-3-4", "kind": "cancer", "name": "Group 3 and group 4 medulloblastoma", "url": "https://onco.cc/cancers/medulloblastoma-group-3-4/" }, { "id": "medulloblastoma-shh", "kind": "cancer", "name": "SHH-activated medulloblastoma", "url": "https://onco.cc/cancers/medulloblastoma-shh/" } ] } }, { "id": "https://doi.org/10.2967/jnumed.126.273553#onco-edge-paper", "url": "https://doi.org/10.2967/jnumed.126.273553", "title": "CD70-Targeted PET/CT in a Patient with von Hippel-Lindau Syndrome and Clear Cell Renal Cell Carcinoma.", "content_text": "Published in J Nucl Med on 15 October 2026; matched the OnCo record for CD70.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Nucl Med", "doi": "10.2967/jnumed.126.273553", "records": [ { "id": "cd70", "kind": "target", "name": "CD70", "url": "https://onco.cc/targets/cd70/" } ] } }, { "id": "https://doi.org/10.1080/09553002.2026.2739263#onco-edge-paper", "url": "https://doi.org/10.1080/09553002.2026.2739263", "title": "CDK4/6 inhibition radiosensitizes p16-negative squamous cell carcinomas of the aerodigestive tract via cell cycle arrest.", "content_text": "Published in Int J Radiat Biol on 15 October 2026; matched the OnCo record for Abemaciclib.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Int J Radiat Biol", "doi": "10.1080/09553002.2026.2739263", "records": [ { "id": "abemaciclib", "kind": "drug", "name": "Abemaciclib", "url": "https://onco.cc/drugs/abemaciclib/" } ] } }, { "id": "https://doi.org/10.1093/oncolo/oyag417#onco-edge-paper", "url": "https://doi.org/10.1093/oncolo/oyag417", "title": "Cerebrospinal Fluid Tumor-Derived DNA Analysis Aids in the Diagnosis of Postpartum Diffuse Midline Glioma.", "content_text": "Published in Oncologist on 15 October 2026; matched the OnCo record for Diffuse midline glioma, H3 K27-altered.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Oncologist", "doi": "10.1093/oncolo/oyag417", "records": [ { "id": "dipg-dmg", "kind": "cancer", "name": "Diffuse midline glioma, H3 K27-altered", "url": "https://onco.cc/cancers/dipg-dmg/" }, { "id": "dordaviprone", "kind": "drug", "name": "Dordaviprone", "url": "https://onco.cc/drugs/dordaviprone/" }, { "id": "h3-3a", "kind": "target", "name": "Histone H3.3", "url": "https://onco.cc/targets/h3-3a/" } ] } }, { "id": "https://doi.org/10.1002/1545-5017.70767#onco-edge-paper", "url": "https://doi.org/10.1002/1545-5017.70767", "title": "Clinical Characteristics of Intracranial Hemorrhage in Pediatric Acute Leukemia.", "content_text": "Published in Pediatr Blood Cancer on 15 October 2026; matched the OnCo record for KMT2A (MLL) rearrangement.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Pediatr Blood Cancer", "doi": "10.1002/1545-5017.70767", "records": [ { "id": "kmt2a", "kind": "target", "name": "KMT2A (MLL) rearrangement", "url": "https://onco.cc/targets/kmt2a/" } ] } }, { "id": "https://doi.org/10.1016/j.trim.2026.102467#onco-edge-paper", "url": "https://doi.org/10.1016/j.trim.2026.102467", "title": "Clinical relevance of the newly reclassified HLA-C*04:09L low-expression allele in allogeneic hematopoietic cell transplantation: a case report.", "content_text": "Published in Transpl Immunol on 15 October 2026; matched the OnCo record for HLA-C.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Transpl Immunol", "doi": "10.1016/j.trim.2026.102467", "records": [ { "id": "hla-c", "kind": "target", "name": "HLA-C", "url": "https://onco.cc/targets/hla-c/" } ] } }, { "id": "https://doi.org/10.1053/j.semnuclmed.2026.09.002#onco-edge-paper", "url": "https://doi.org/10.1053/j.semnuclmed.2026.09.002", "title": "Clinical translation of targeted alpha therapy: safety, dosimetry, radiation protection, and regulatory considerations.", "content_text": "Published in Semin Nucl Med on 15 October 2026; matched the OnCo record for Targeted alpha therapy.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Semin Nucl Med", "doi": "10.1053/j.semnuclmed.2026.09.002", "records": [ { "id": "targeted-alpha-therapy", "kind": "technology", "name": "Targeted alpha therapy", "url": "https://onco.cc/technologies/targeted-alpha-therapy/" } ] } }, { "id": "https://doi.org/10.1038/s41585-026-01193-0#onco-edge-paper", "url": "https://doi.org/10.1038/s41585-026-01193-0", "title": "Combination therapy for BCG-unresponsive non-muscle-invasive bladder cancer: biological rationale and ongoing clinical strategies.", "content_text": "Published in Nat Rev Urol on 15 October 2026; matched the OnCo record for Nadofaragene firadenovec.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Nat Rev Urol", "doi": "10.1038/s41585-026-01193-0", "records": [ { "id": "nadofaragene-firadenovec", "kind": "drug", "name": "Nadofaragene firadenovec", "url": "https://onco.cc/drugs/nadofaragene-firadenovec/" }, { "id": "valrubicin", "kind": "drug", "name": "Valrubicin", "url": "https://onco.cc/drugs/valrubicin/" } ] } }, { "id": "https://doi.org/10.1007/s11701-026-04056-3#onco-edge-paper", "url": "https://doi.org/10.1007/s11701-026-04056-3", "title": "Correction: Transoral Robotic Surgery (TORS) versus radical radiotherapy following neoadjuvant therapy for oropharyngeal carcinoma: a multicenter, real-world efficacy and safety analysis.", "content_text": "Published in J Robot Surg on 15 October 2026; matched the OnCo record for Transoral robotic surgery.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Robot Surg", "doi": "10.1007/s11701-026-04056-3", "records": [ { "id": "tors", "kind": "technology", "name": "Transoral robotic surgery", "url": "https://onco.cc/technologies/tors/" } ] } }, { "id": "https://doi.org/10.1002/wjo2.70174#onco-edge-paper", "url": "https://doi.org/10.1002/wjo2.70174", "title": "Correspondence of Papillary Thyroid Cancer With Cutaneous Metastasis in Thyroidology.", "content_text": "Published in World J Otorhinolaryngol Head Neck Surg on 15 October 2026; matched the OnCo record for PAX8.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "World J Otorhinolaryngol Head Neck Surg", "doi": "10.1002/wjo2.70174", "records": [ { "id": "pax8", "kind": "target", "name": "PAX8", "url": "https://onco.cc/targets/pax8/" } ] } }, { "id": "https://doi.org/10.1080/14737167.2026.2746857#onco-edge-paper", "url": "https://doi.org/10.1080/14737167.2026.2746857", "title": "Cost-effectiveness of amivantamab plus lazertinib and osimertinib plus chemotherapy versus osimertinib monotherapy for first-line EGFR-mutated advanced non-small cell lung cancer: an updated analysis.", "content_text": "Published in Expert Rev Pharmacoecon Outcomes Res on 15 October 2026; matched the OnCo record for Amivantamab.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Expert Rev Pharmacoecon Outcomes Res", "doi": "10.1080/14737167.2026.2746857", "records": [ { "id": "amivantamab", "kind": "drug", "name": "Amivantamab", "url": "https://onco.cc/drugs/amivantamab/" }, { "id": "lazertinib", "kind": "drug", "name": "Lazertinib", "url": "https://onco.cc/drugs/lazertinib/" } ] } }, { "id": "https://doi.org/10.1016/j.jval.2026.10.002#onco-edge-paper", "url": "https://doi.org/10.1016/j.jval.2026.10.002", "title": "Cost-Effectiveness of Telisotuzumab Vedotin-tllv for Previously Treated High c-Met Protein-Overexpressing Nonsquamous Non-Small Cell Lung Cancer in the United States.", "content_text": "Published in Value Health on 15 October 2026; matched the OnCo record for Telisotuzumab vedotin.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Value Health", "doi": "10.1016/j.jval.2026.10.002", "records": [ { "id": "telisotuzumab-vedotin", "kind": "drug", "name": "Telisotuzumab vedotin", "url": "https://onco.cc/drugs/telisotuzumab-vedotin/" } ] } }, { "id": "https://doi.org/10.1016/j.canlet.2026.218888#onco-edge-paper", "url": "https://doi.org/10.1016/j.canlet.2026.218888", "title": "CRISPR-based interrogation of alternative lengthening of telomeres: mapping dependencies, stress-buffering pathways, and therapeutic vulnerabilities.", "content_text": "Published in Cancer Lett on 15 October 2026; matched the OnCo record for FANCM.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cancer Lett", "doi": "10.1016/j.canlet.2026.218888", "records": [ { "id": "fancm", "kind": "target", "name": "FANCM", "url": "https://onco.cc/targets/fancm/" } ] } }, { "id": "https://doi.org/10.1158/2326-6066.cir-26-0181#onco-edge-paper", "url": "https://doi.org/10.1158/2326-6066.cir-26-0181", "title": "Cullin-5 RING E3 ligase limits CD8⁺ T-cell persistence and effector responses during chronic antigen stimulation.", "content_text": "Published in Cancer Immunol Res on 15 October 2026; matched the OnCo record for CTAG1B.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cancer Immunol Res", "doi": "10.1158/2326-6066.cir-26-0181", "records": [ { "id": "ctag1b", "kind": "target", "name": "CTAG1B", "url": "https://onco.cc/targets/ctag1b/" }, { "id": "pevonedistat", "kind": "drug", "name": "Pevonedistat", "url": "https://onco.cc/drugs/pevonedistat/" } ] } }, { "id": "https://doi.org/10.1080/14656566.2026.2749650#onco-edge-paper", "url": "https://doi.org/10.1080/14656566.2026.2749650", "title": "Current management and emerging pharmacotherapeutic strategies in acute promyelocytic leukemia.", "content_text": "Published in Expert Opin Pharmacother on 15 October 2026; matched the OnCo record for Arsenic trioxide.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Expert Opin Pharmacother", "doi": "10.1080/14656566.2026.2749650", "records": [ { "id": "arsenic-trioxide", "kind": "drug", "name": "Arsenic trioxide", "url": "https://onco.cc/drugs/arsenic-trioxide/" }, { "id": "cd33", "kind": "target", "name": "CD33", "url": "https://onco.cc/targets/cd33/" }, { "id": "gemtuzumab-ozogamicin", "kind": "drug", "name": "Gemtuzumab ozogamicin", "url": "https://onco.cc/drugs/gemtuzumab-ozogamicin/" } ] } }, { "id": "https://doi.org/10.1177/15473287261497533#onco-edge-paper", "url": "https://doi.org/10.1177/15473287261497533", "title": "CXM102 Regulates the Multiple Differentiation and Anti-Inflammation of Human Bone Marrow-Derived Leptin Receptor-Positive Stromal Cells <i>In Vitro</i>.", "content_text": "Published in Stem Cells Dev on 15 October 2026; matched the OnCo record for LEPR.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Stem Cells Dev", "doi": "10.1177/15473287261497533", "records": [ { "id": "lepr", "kind": "target", "name": "LEPR", "url": "https://onco.cc/targets/lepr/" } ] } }, { "id": "https://doi.org/10.1001/jamaophthalmol.2026.4378#onco-edge-paper", "url": "https://doi.org/10.1001/jamaophthalmol.2026.4378", "title": "Cytopathology and Prognostic Accuracy of 15-GEP/PRAME: The Collaborative Ocular Oncology Group Study 2.", "content_text": "Published in JAMA Ophthalmol on 15 October 2026; matched the OnCo record for PRAME.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "JAMA Ophthalmol", "doi": "10.1001/jamaophthalmol.2026.4378", "records": [ { "id": "prame", "kind": "target", "name": "PRAME", "url": "https://onco.cc/targets/prame/" }, { "id": "uveal-melanoma", "kind": "cancer", "name": "Uveal melanoma", "url": "https://onco.cc/cancers/uveal-melanoma/" } ] } }, { "id": "https://doi.org/10.1186/s12885-026-16748-y#onco-edge-paper", "url": "https://doi.org/10.1186/s12885-026-16748-y", "title": "Decoupling T cell cytotoxicity: a CCL21+ICAM1-based synthetic immune niche enhances tumor elimination by accelerating lytic hit delivery.", "content_text": "Published on 15 October 2026 after first appearing as a preprint; matched CD8.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "doi": "10.1186/s12885-026-16748-y", "records": [ { "id": "cd8", "kind": "target", "name": "CD8", "url": "https://onco.cc/targets/cd8/" } ] } }, { "id": "https://doi.org/10.1016/j.urology.2026.10.010#onco-edge-paper", "url": "https://doi.org/10.1016/j.urology.2026.10.010", "title": "Diet quality and prognosis in patients with non-muscle invasive bladder cancer: the Be-Well Study.", "content_text": "Published in Urology on 15 October 2026; matched the OnCo record for Mitomycin C.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Urology", "doi": "10.1016/j.urology.2026.10.010", "records": [ { "id": "mitomycin", "kind": "drug", "name": "Mitomycin C", "url": "https://onco.cc/drugs/mitomycin/" } ] } }, { "id": "https://doi.org/10.1158/2326-6066.cir-26-0608#onco-edge-paper", "url": "https://doi.org/10.1158/2326-6066.cir-26-0608", "title": "Disruption of the CRL5 ubiquitin ligase complex enhances engineered T-cell persistence under chronic tumor antigen exposure.", "content_text": "Published in Cancer Immunol Res on 15 October 2026; matched the OnCo record for Cytokines & engineered cytokines.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cancer Immunol Res", "doi": "10.1158/2326-6066.cir-26-0608", "records": [ { "id": "cytokine-therapy", "kind": "technology", "name": "Cytokines & engineered cytokines", "url": "https://onco.cc/technologies/cytokine-therapy/" } ] } }, { "id": "https://doi.org/10.1002/ccr3.73745#onco-edge-paper", "url": "https://doi.org/10.1002/ccr3.73745", "title": "Disseminated Mixed Lytic-Sclerotic Skeletal Metastases as Initial Presentation of Gallbladder Carcinoma: A Case Report.", "content_text": "Published in Clin Case Rep on 15 October 2026; matched the OnCo record for Gallbladder cancer.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Clin Case Rep", "doi": "10.1002/ccr3.73745", "records": [ { "id": "gallbladder", "kind": "cancer", "name": "Gallbladder cancer", "url": "https://onco.cc/cancers/gallbladder/" } ] } }, { "id": "https://doi.org/10.3390/cancers18203331#onco-edge-paper", "url": "https://doi.org/10.3390/cancers18203331", "title": "Early Local Tumour Control and Feasibility of Intratumoral P-32 Microparticle Implantation in Patients with Locally Advanced Pancreatic Cancer: A Prospective Single-Center Observational Cohort Study.", "content_text": "Published on 15 October 2026 after first appearing as a preprint; matched Nab-paclitaxel, SPECT & bone scan and Gemcitabine.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "doi": "10.3390/cancers18203331", "records": [ { "id": "nab-paclitaxel", "kind": "drug", "name": "Nab-paclitaxel", "url": "https://onco.cc/drugs/nab-paclitaxel/" }, { "id": "spect", "kind": "technology", "name": "SPECT & bone scan", "url": "https://onco.cc/technologies/spect/" }, { "id": "gemcitabine", "kind": "drug", "name": "Gemcitabine", "url": "https://onco.cc/drugs/gemcitabine/" }, { "id": "phosphorus-32", "kind": "drug", "name": "Phosphorus-32", "url": "https://onco.cc/drugs/phosphorus-32/" }, { "id": "spect-ct", "kind": "technology", "name": "SPECT/CT", "url": "https://onco.cc/technologies/spect-ct/" } ] } }, { "id": "https://doi.org/10.17219/acem/215822#onco-edge-paper", "url": "https://doi.org/10.17219/acem/215822", "title": "Efficacy of continuous ibrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia with high-burden and low-burden TP53 mutations: Multicenter retrospective analysis of the Polish Adult Leukemia Group (PALG).", "content_text": "Published in Adv Clin Exp Med on 15 October 2026; matched the OnCo record for Relapsed or refractory chronic lymphocytic leukaemia.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Adv Clin Exp Med", "doi": "10.17219/acem/215822", "records": [ { "id": "cll-relapsed", "kind": "cancer", "name": "Relapsed or refractory chronic lymphocytic leukaemia", "url": "https://onco.cc/cancers/cll-relapsed/" } ] } }, { "id": "https://doi.org/10.1093/neuonc/noag174#onco-edge-paper", "url": "https://doi.org/10.1093/neuonc/noag174", "title": "Emergence of inactivating NOTCH1 mutations in an IDH-mutant astrocytoma with clinical resistance to vorasidenib treatment.", "content_text": "Published in Neuro Oncol on 15 October 2026; matched the OnCo record for Astrocytoma, IDH-mutant.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Neuro Oncol", "doi": "10.1093/neuonc/noag174", "records": [ { "id": "idh-mutant-astrocytoma", "kind": "cancer", "name": "Astrocytoma, IDH-mutant", "url": "https://onco.cc/cancers/idh-mutant-astrocytoma/" }, { "id": "vorasidenib", "kind": "drug", "name": "Vorasidenib", "url": "https://onco.cc/drugs/vorasidenib/" } ] } }, { "id": "https://doi.org/10.1073/pnas.2613054123#onco-edge-paper", "url": "https://doi.org/10.1073/pnas.2613054123", "title": "Environmental chemical mixtures reprogram mammary epithelial development to epigenetic states associated with breast cancer.", "content_text": "Published on 15 October 2026 after first appearing as a preprint; matched DNA methylation profiling.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "doi": "10.1073/pnas.2613054123", "records": [ { "id": "methylation-profiling", "kind": "technology", "name": "DNA methylation profiling", "url": "https://onco.cc/technologies/methylation-profiling/" } ] } }, { "id": "https://doi.org/10.1007/s00345-026-06811-5#onco-edge-paper", "url": "https://doi.org/10.1007/s00345-026-06811-5", "title": "EQUIPOISE: EQUivalence In Prostate cancer treatment: surgery Or radiotherapy? An Intention-to-treat Survival analysis from real-world Evidence.", "content_text": "Published in World J Urol on 15 October 2026; matched the OnCo record for SCN9A.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "World J Urol", "doi": "10.1007/s00345-026-06811-5", "records": [ { "id": "scn9a", "kind": "target", "name": "SCN9A", "url": "https://onco.cc/targets/scn9a/" } ] } }, { "id": "https://doi.org/10.1177/00220345261478636#onco-edge-paper", "url": "https://doi.org/10.1177/00220345261478636", "title": "Fanconi Anemia: Matrix Remodeling and Oral Carcinogenesis.", "content_text": "Published in J Dent Res on 15 October 2026; matched the OnCo record for FANCA.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Dent Res", "doi": "10.1177/00220345261478636", "records": [ { "id": "fanca", "kind": "target", "name": "FANCA", "url": "https://onco.cc/targets/fanca/" } ] } }, { "id": "https://doi.org/10.1182/bloodadvances.2026020724#onco-edge-paper", "url": "https://doi.org/10.1182/bloodadvances.2026020724", "title": "Flow MRD pre-blinatumomab consolidation, despite subsequent clearance, is associated with inferior survival in Ph+ B-ALL.", "content_text": "Published in Blood Adv on 15 October 2026; matched the OnCo record for Blinatumomab.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Blood Adv", "doi": "10.1182/bloodadvances.2026020724", "records": [ { "id": "blinatumomab", "kind": "drug", "name": "Blinatumomab", "url": "https://onco.cc/drugs/blinatumomab/" }, { "id": "ikzf1", "kind": "target", "name": "IKZF1", "url": "https://onco.cc/targets/ikzf1/" } ] } }, { "id": "https://doi.org/10.1002/path.70137#onco-edge-paper", "url": "https://doi.org/10.1002/path.70137", "title": "FOXC2 regulates macrophage polarization and osteosarcoma progression via the CXCL12/CXCR4 signaling axis.", "content_text": "Published in J Pathol on 15 October 2026; matched the OnCo record for FOXC2.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Pathol", "doi": "10.1002/path.70137", "records": [ { "id": "foxc2", "kind": "target", "name": "FOXC2", "url": "https://onco.cc/targets/foxc2/" } ] } }, { "id": "https://doi.org/10.1016/j.ygyno.2026.10.009#onco-edge-paper", "url": "https://doi.org/10.1016/j.ygyno.2026.10.009", "title": "Genomic characterization of advanced and recurrent endometrial carcinoma: KRAS and TP53 co-mutation as a biomarker for adverse prognosis and therapeutic failure.", "content_text": "Published in Gynecol Oncol on 15 October 2026; matched the OnCo record for Advanced or recurrent endometrial cancer.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Gynecol Oncol", "doi": "10.1016/j.ygyno.2026.10.009", "records": [ { "id": "advanced-recurrent-endometrial-cancer", "kind": "cancer", "name": "Advanced or recurrent endometrial cancer", "url": "https://onco.cc/cancers/advanced-recurrent-endometrial-cancer/" } ] } }, { "id": "https://doi.org/10.70962/jhi.20260123#onco-edge-paper", "url": "https://doi.org/10.70962/jhi.20260123", "title": "Hematopoietic cell transplantation using treosulfan-based conditioning for IL-10 receptor deficiency.", "content_text": "Published in J Hum Immun on 15 October 2026; matched the OnCo record for Interleukin-10.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Hum Immun", "doi": "10.70962/jhi.20260123", "records": [ { "id": "il10", "kind": "target", "name": "Interleukin-10", "url": "https://onco.cc/targets/il10/" }, { "id": "treosulfan", "kind": "drug", "name": "Treosulfan", "url": "https://onco.cc/drugs/treosulfan/" } ] } }, { "id": "https://doi.org/10.14309/crj.0000000000002355#onco-edge-paper", "url": "https://doi.org/10.14309/crj.0000000000002355", "title": "Hidden in Plain Sight: Gastric Adenocarcinoma in Endoscopically Normal Mucosa in a CDH1 Mutation Carrier.", "content_text": "Published in ACG Case Rep J on 15 October 2026; matched the OnCo record for CDH1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "ACG Case Rep J", "doi": "10.14309/crj.0000000000002355", "records": [ { "id": "cdh1", "kind": "target", "name": "CDH1", "url": "https://onco.cc/targets/cdh1/" } ] } }, { "id": "https://doi.org/10.1016/j.celrep.2026.118149#onco-edge-paper", "url": "https://doi.org/10.1016/j.celrep.2026.118149", "title": "Histone H3K27 methylation states are sequentially catalyzed in cycling cells.", "content_text": "Published on 15 October 2026 after first appearing as a preprint; matched EZH2 and H3C14.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "doi": "10.1016/j.celrep.2026.118149", "records": [ { "id": "ezh2", "kind": "target", "name": "EZH2", "url": "https://onco.cc/targets/ezh2/" }, { "id": "h3c14", "kind": "target", "name": "H3C14", "url": "https://onco.cc/targets/h3c14/" } ] } }, { "id": "https://doi.org/10.1007/s10689-026-00611-x#onco-edge-paper", "url": "https://doi.org/10.1007/s10689-026-00611-x", "title": "Histopathological and immunohistochemical analyses do not indicate timing of prophylactic hysterectomy: a retrospective analysis of endometrial biopsies in Lynch syndrome carriers.", "content_text": "Published in Fam Cancer on 15 October 2026; matched the OnCo record for ARID1A.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Fam Cancer", "doi": "10.1007/s10689-026-00611-x", "records": [ { "id": "arid1a", "kind": "target", "name": "ARID1A", "url": "https://onco.cc/targets/arid1a/" } ] } }, { "id": "https://doi.org/10.1080/22221751.2026.2744492#onco-edge-paper", "url": "https://doi.org/10.1080/22221751.2026.2744492", "title": "HLA profiles and susceptibility to Alveolar echinococcosis: evidence from a large cohort with population and household controls.", "content_text": "Published in Emerg Microbes Infect on 15 October 2026; matched the OnCo record for HLA-A.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Emerg Microbes Infect", "doi": "10.1080/22221751.2026.2744492", "records": [ { "id": "hla-a", "kind": "target", "name": "HLA-A", "url": "https://onco.cc/targets/hla-a/" } ] } }, { "id": "https://doi.org/10.3324/haematol.2026.301348#onco-edge-paper", "url": "https://doi.org/10.3324/haematol.2026.301348", "title": "Hyperinflammatory differentiation syndrome with hemophagocytic lymphohistiocytosis-like features following menin inhibition in acute myeloid leukemia.", "content_text": "Published in Haematologica on 15 October 2026; matched the OnCo record for Menin.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Haematologica", "doi": "10.3324/haematol.2026.301348", "records": [ { "id": "menin", "kind": "target", "name": "Menin", "url": "https://onco.cc/targets/menin/" } ] } }, { "id": "https://doi.org/10.1371/journal.pdig.0001777#onco-edge-paper", "url": "https://doi.org/10.1371/journal.pdig.0001777", "title": "Identifying facilitators of and barriers to digital health literacy in pediatric rheumatic disease: A scoping review.", "content_text": "Published in PLOS Digit Health on 15 October 2026; matched the OnCo record for High-grade B-cell lymphoma with MYC and BCL2 rearrangements.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "PLOS Digit Health", "doi": "10.1371/journal.pdig.0001777", "records": [ { "id": "high-grade-b-cell-lymphoma-myc-bcl2", "kind": "cancer", "name": "High-grade B-cell lymphoma with MYC and BCL2 rearrangements", "url": "https://onco.cc/cancers/high-grade-b-cell-lymphoma-myc-bcl2/" } ] } }, { "id": "https://doi.org/10.1097/dad.0000000000003457#onco-edge-paper", "url": "https://doi.org/10.1097/dad.0000000000003457", "title": "Immunohistochemical Analysis of INSM1, MCPyV, and PHOX2B Expression in Merkel Cell Carcinoma.", "content_text": "Published in Am J Dermatopathol on 15 October 2026; matched the OnCo record for PHOX2B.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Am J Dermatopathol", "doi": "10.1097/dad.0000000000003457", "records": [ { "id": "phox2b", "kind": "target", "name": "PHOX2B", "url": "https://onco.cc/targets/phox2b/" } ] } }, { "id": "https://doi.org/10.1016/j.ygyno.2026.10.007#onco-edge-paper", "url": "https://doi.org/10.1016/j.ygyno.2026.10.007", "title": "Impact of adjuvant treatment on survival in surgically staged 2009 FIGO stage I uterine serous carcinoma.", "content_text": "Published in Gynecol Oncol on 15 October 2026; matched the OnCo record for p53-abnormal endometrial cancer, including uterine serous carcinoma.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Gynecol Oncol", "doi": "10.1016/j.ygyno.2026.10.007", "records": [ { "id": "endometrial-p53-abnormal", "kind": "cancer", "name": "p53-abnormal endometrial cancer, including uterine serous carcinoma", "url": "https://onco.cc/cancers/endometrial-p53-abnormal/" } ] } }, { "id": "https://doi.org/10.1177/10781552261497955#onco-edge-paper", "url": "https://doi.org/10.1177/10781552261497955", "title": "Impact of comedication on survival and toxicity in patients treated with systemic therapy for unresectable hepatocellular carcinoma.", "content_text": "Published in J Oncol Pharm Pract on 15 October 2026; matched the OnCo record for Tremelimumab.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Oncol Pharm Pract", "doi": "10.1177/10781552261497955", "records": [ { "id": "tremelimumab", "kind": "drug", "name": "Tremelimumab", "url": "https://onco.cc/drugs/tremelimumab/" } ] } }, { "id": "https://doi.org/10.4269/ajtmh.26-0352#onco-edge-paper", "url": "https://doi.org/10.4269/ajtmh.26-0352", "title": "Infectious, Environmental, and Chronic Disease Burden among 1,844 Newly Arrived Humanitarian Migrants in Oklahoma, 2019-2025.", "content_text": "Published in Am J Trop Med Hyg on 15 October 2026; matched the OnCo record for Ivermectin.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Am J Trop Med Hyg", "doi": "10.4269/ajtmh.26-0352", "records": [ { "id": "ivermectin", "kind": "drug", "name": "Ivermectin", "url": "https://onco.cc/drugs/ivermectin/" } ] } }, { "id": "https://doi.org/10.1007/s13205-026-05099-x#onco-edge-paper", "url": "https://doi.org/10.1007/s13205-026-05099-x", "title": "Integrated identification of CYP1A1 and CYP1B1 as potential drivers of smoking-related lung carcinogenesis.", "content_text": "Published in 3 Biotech on 15 October 2026; matched the OnCo record for CYP1B1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "3 Biotech", "doi": "10.1007/s13205-026-05099-x", "records": [ { "id": "cyp1b1", "kind": "target", "name": "CYP1B1", "url": "https://onco.cc/targets/cyp1b1/" }, { "id": "hla-dr", "kind": "target", "name": "HLA-DR", "url": "https://onco.cc/targets/hla-dr/" }, { "id": "hla-dra", "kind": "target", "name": "HLA-DRA", "url": "https://onco.cc/targets/hla-dra/" } ] } }, { "id": "https://doi.org/10.1097/spc.0000000000000828#onco-edge-paper", "url": "https://doi.org/10.1097/spc.0000000000000828", "title": "Integrated models of palliative medicine and pain management for the treatment of cancer-related pain: a review.", "content_text": "Published in Curr Opin Support Palliat Care on 15 October 2026; matched the OnCo record for Cancer pain management.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Curr Opin Support Palliat Care", "doi": "10.1097/spc.0000000000000828", "records": [ { "id": "pain-management", "kind": "technology", "name": "Cancer pain management", "url": "https://onco.cc/technologies/pain-management/" } ] } }, { "id": "https://doi.org/10.1007/s00210-026-05933-2#onco-edge-paper", "url": "https://doi.org/10.1007/s00210-026-05933-2", "title": "Investigating potential prognostic genes and candidate therapeutic targets for acute myeloid leukemia in food-medicine homologous plants via integrated network pharmacology and transcriptomics.", "content_text": "Published in Naunyn Schmiedebergs Arch Pharmacol on 15 October 2026; matched the OnCo record for ITGB3.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Naunyn Schmiedebergs Arch Pharmacol", "doi": "10.1007/s00210-026-05933-2", "records": [ { "id": "itgb3", "kind": "target", "name": "ITGB3", "url": "https://onco.cc/targets/itgb3/" }, { "id": "myb", "kind": "target", "name": "MYB", "url": "https://onco.cc/targets/myb/" }, { "id": "mybl1", "kind": "target", "name": "MYBL1", "url": "https://onco.cc/targets/mybl1/" } ] } }, { "id": "https://doi.org/10.1182/bloodadvances.2026020494#onco-edge-paper", "url": "https://doi.org/10.1182/bloodadvances.2026020494", "title": "Loncastuximab and Rituximab in Elderly Unfit/Frail Patients With Previously Untreated Diffuse Large B-Cell Lymphoma.", "content_text": "Published in Blood Adv on 15 October 2026; matched the OnCo record for Loncastuximab tesirine.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Blood Adv", "doi": "10.1182/bloodadvances.2026020494", "records": [ { "id": "zynlonta", "kind": "drug", "name": "Loncastuximab tesirine", "url": "https://onco.cc/drugs/zynlonta/" } ] } }, { "id": "https://doi.org/10.1007/s11095-026-04223-z#onco-edge-paper", "url": "https://doi.org/10.1007/s11095-026-04223-z", "title": "Long-lasting Inhibition of L-type Amino Acid Transporter 1 by Nanvuranlat is Associated with Prolonged Cellular Retention Counteracted by Cancer-type OATP1B3 in Cholangiocarcinoma Cells.", "content_text": "Published in Pharm Res on 15 October 2026; matched the OnCo record for NVL.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Pharm Res", "doi": "10.1007/s11095-026-04223-z", "records": [ { "id": "nvl", "kind": "target", "name": "NVL", "url": "https://onco.cc/targets/nvl/" } ] } }, { "id": "https://doi.org/10.1177/00048674261493339#onco-edge-paper", "url": "https://doi.org/10.1177/00048674261493339", "title": "Lung cancer incidence, metastatic disease and mortality in people accessing mental health services: Opportunities for screening.", "content_text": "Published in Aust N Z J Psychiatry on 15 October 2026; matched the OnCo record for NHS Targeted Lung Health Check.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Aust N Z J Psychiatry", "doi": "10.1177/00048674261493339", "records": [ { "id": "nhs-targeted-lung-health-check", "kind": "technology", "name": "NHS Targeted Lung Health Check", "url": "https://onco.cc/technologies/nhs-targeted-lung-health-check/" } ] } }, { "id": "https://doi.org/10.1016/j.celrep.2026.118130#onco-edge-paper", "url": "https://doi.org/10.1016/j.celrep.2026.118130", "title": "Lymphangiogenesis driven by VEGF-C reshapes tumor immune landscape and enables tumor eradication by viral immunotherapy in mouse melanoma models.", "content_text": "Published in Cell Rep on 15 October 2026; matched the OnCo record for VEGFC.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cell Rep", "doi": "10.1016/j.celrep.2026.118130", "records": [ { "id": "vegfc", "kind": "target", "name": "VEGFC", "url": "https://onco.cc/targets/vegfc/" } ] } }, { "id": "https://doi.org/10.1007/s12094-026-04588-y#onco-edge-paper", "url": "https://doi.org/10.1007/s12094-026-04588-y", "title": "MACC1 in colorectal cancer: a claim-level evidence audit from metastasis driver to proposed microenvironmental regulator.", "content_text": "Published in Clin Transl Oncol on 15 October 2026; matched the OnCo record for MACC1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Clin Transl Oncol", "doi": "10.1007/s12094-026-04588-y", "records": [ { "id": "macc1", "kind": "target", "name": "MACC1", "url": "https://onco.cc/targets/macc1/" } ] } }, { "id": "https://doi.org/10.1016/j.euo.2026.09.015#onco-edge-paper", "url": "https://doi.org/10.1016/j.euo.2026.09.015", "title": "Machine Learning Models Combining [<sup>68</sup>Ga]Ga-PSMA-11 PET Radiomics and Clinical Features to Predict Overall Survival for Metastatic Castration-resistant Prostate Cancer Treated with [<sup>177</sup>Lu]Lu-PSMA Radioligand Therapy.", "content_text": "Published in Eur Urol Oncol on 15 October 2026; matched the OnCo record for Gallium-68 gozetotide.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Eur Urol Oncol", "doi": "10.1016/j.euo.2026.09.015", "records": [ { "id": "ga68-psma-11", "kind": "drug", "name": "Gallium-68 gozetotide", "url": "https://onco.cc/drugs/ga68-psma-11/" }, { "id": "lu177-radioligand-therapy", "kind": "technology", "name": "Lutetium-177 radioligand therapy", "url": "https://onco.cc/technologies/lu177-radioligand-therapy/" } ] } }, { "id": "https://doi.org/10.1080/17434440.2026.2749360#onco-edge-paper", "url": "https://doi.org/10.1080/17434440.2026.2749360", "title": "Mechanical ventilation before and during veno-venous extracorporeal membrane oxygenation.", "content_text": "Published in Expert Rev Med Devices on 15 October 2026; matched the OnCo record for Visual inspection with acetic acid (VIA) for cervical screening.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Expert Rev Med Devices", "doi": "10.1080/17434440.2026.2749360", "records": [ { "id": "via-cervical-screening", "kind": "technology", "name": "Visual inspection with acetic acid (VIA) for cervical screening", "url": "https://onco.cc/technologies/via-cervical-screening/" } ] } }, { "id": "https://doi.org/10.1007/s10495-026-02462-4#onco-edge-paper", "url": "https://doi.org/10.1007/s10495-026-02462-4", "title": "Mechanistic insights and therapeutic implications of mitoxyperilysis: a spatially gated mitochondria-dependent lytic cell death.", "content_text": "Published in Apoptosis on 15 October 2026; matched the OnCo record for RICTOR.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Apoptosis", "doi": "10.1007/s10495-026-02462-4", "records": [ { "id": "rictor", "kind": "target", "name": "RICTOR", "url": "https://onco.cc/targets/rictor/" } ] } }, { "id": "https://doi.org/10.1007/s10689-026-00609-5#onco-edge-paper", "url": "https://doi.org/10.1007/s10689-026-00609-5", "title": "Moderate-risk variants in hereditary breast and ovarian cancer: seven-year experience from a specialized center.", "content_text": "Published in Fam Cancer on 15 October 2026; matched the OnCo record for BARD1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Fam Cancer", "doi": "10.1007/s10689-026-00609-5", "records": [ { "id": "bard1", "kind": "target", "name": "BARD1", "url": "https://onco.cc/targets/bard1/" }, { "id": "chek2", "kind": "target", "name": "CHEK2", "url": "https://onco.cc/targets/chek2/" }, { "id": "rad51c", "kind": "target", "name": "RAD51C", "url": "https://onco.cc/targets/rad51c/" }, { "id": "rad51d", "kind": "target", "name": "RAD51D", "url": "https://onco.cc/targets/rad51d/" } ] } }, { "id": "https://doi.org/10.1002/cai2.70082#onco-edge-paper", "url": "https://doi.org/10.1002/cai2.70082", "title": "Molecular Mechanisms and Therapeutic Advances in KRAS G12C-Mutant Non-Small Cell Lung Cancer: Toward Mechanism-Guided Longitudinal Management.", "content_text": "Published in Cancer Innov on 15 October 2026; matched the OnCo record for Adagrasib.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cancer Innov", "doi": "10.1002/cai2.70082", "records": [ { "id": "adagrasib", "kind": "drug", "name": "Adagrasib", "url": "https://onco.cc/drugs/adagrasib/" }, { "id": "kras-g12c-nsclc", "kind": "cancer", "name": "KRAS G12C-mutant non-small-cell lung cancer", "url": "https://onco.cc/cancers/kras-g12c-nsclc/" }, { "id": "sotorasib", "kind": "drug", "name": "Sotorasib", "url": "https://onco.cc/drugs/sotorasib/" }, { "id": "stk11", "kind": "target", "name": "STK11", "url": "https://onco.cc/targets/stk11/" } ] } }, { "id": "https://doi.org/10.1002/ccr3.73700#onco-edge-paper", "url": "https://doi.org/10.1002/ccr3.73700", "title": "Multidisciplinary Management of a Giant Ovarian Sertoli-Leydig Cell Tumor Presenting With Isosexual Precocious Puberty: A Pediatric Case Report.", "content_text": "Published in Clin Case Rep on 15 October 2026; matched the OnCo record for Leydig cell tumour of the testis.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Clin Case Rep", "doi": "10.1002/ccr3.73700", "records": [ { "id": "leydig-cell-tumour", "kind": "cancer", "name": "Leydig cell tumour of the testis", "url": "https://onco.cc/cancers/leydig-cell-tumour/" } ] } }, { "id": "https://doi.org/10.1172/jci202305#onco-edge-paper", "url": "https://doi.org/10.1172/jci202305", "title": "Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.", "content_text": "Published in J Clin Invest on 15 October 2026; matched the OnCo record for Rivoceranib.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Clin Invest", "doi": "10.1172/jci202305", "records": [ { "id": "rivoceranib", "kind": "drug", "name": "Rivoceranib", "url": "https://onco.cc/drugs/rivoceranib/" } ] } }, { "id": "https://doi.org/10.1080/00207454.2026.2749808#onco-edge-paper", "url": "https://doi.org/10.1080/00207454.2026.2749808", "title": "Multimodal based Brain Tumor Classification using Clustered Federated Learning in Edge based IoT Network.", "content_text": "Published in Int J Neurosci on 15 October 2026; matched the OnCo record for TPR.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Int J Neurosci", "doi": "10.1080/00207454.2026.2749808", "records": [ { "id": "tpr", "kind": "target", "name": "TPR", "url": "https://onco.cc/targets/tpr/" } ] } }, { "id": "https://doi.org/10.1016/j.xgen.2026.101397#onco-edge-paper", "url": "https://doi.org/10.1016/j.xgen.2026.101397", "title": "NeoBridge: Biophysics-informed neoantigen prioritization and clonal architecture profiling in pancreatic cancer.", "content_text": "Published in Cell Genom on 15 October 2026; matched the OnCo record for Personalised neoantigen (mRNA) vaccines.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cell Genom", "doi": "10.1016/j.xgen.2026.101397", "records": [ { "id": "neoantigen-mrna-vaccine", "kind": "technology", "name": "Personalised neoantigen (mRNA) vaccines", "url": "https://onco.cc/technologies/neoantigen-mrna-vaccine/" } ] } }, { "id": "https://doi.org/10.1530/erc-26-0317#onco-edge-paper", "url": "https://doi.org/10.1530/erc-26-0317", "title": "New Horizons in Pharmacotherapy for Cushing's Disease and Acromegaly.", "content_text": "Published in Endocr Relat Cancer on 15 October 2026; matched the OnCo record for Somatostatin analogues.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Endocr Relat Cancer", "doi": "10.1530/erc-26-0317", "records": [ { "id": "octreotide-lanreotide", "kind": "drug", "name": "Somatostatin analogues", "url": "https://onco.cc/drugs/octreotide-lanreotide/" }, { "id": "pegvisomant", "kind": "drug", "name": "Pegvisomant", "url": "https://onco.cc/drugs/pegvisomant/" }, { "id": "somatotroph-pitnet", "kind": "cancer", "name": "Somatotroph pituitary neuroendocrine tumour", "url": "https://onco.cc/cancers/somatotroph-pitnet/" } ] } }, { "id": "https://doi.org/10.1007/s12098-026-06494-1#onco-edge-paper", "url": "https://doi.org/10.1007/s12098-026-06494-1", "title": "Nine Years of Vemurafenib Therapy in BRAF V600E-Positive Multisystem Langerhans Cell Histiocytosis with Asymptomatic Neurodegenerative Changes.", "content_text": "Published in Indian J Pediatr on 15 October 2026; matched the OnCo record for Langerhans cell histiocytosis.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Indian J Pediatr", "doi": "10.1007/s12098-026-06494-1", "records": [ { "id": "langerhans-cell-histiocytosis", "kind": "cancer", "name": "Langerhans cell histiocytosis", "url": "https://onco.cc/cancers/langerhans-cell-histiocytosis/" }, { "id": "lch-multisystem", "kind": "cancer", "name": "Multisystem Langerhans cell histiocytosis", "url": "https://onco.cc/cancers/lch-multisystem/" } ] } }, { "id": "https://doi.org/10.1186/s13045-026-01854-y#onco-edge-paper", "url": "https://doi.org/10.1186/s13045-026-01854-y", "title": "Novel antibody-based regimens for large B-cell lymphoma: latest updates from the 2026 ASCO Annual Meeting.", "content_text": "Published in J Hematol Oncol on 15 October 2026; matched the OnCo record for CD79b.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Hematol Oncol", "doi": "10.1186/s13045-026-01854-y", "records": [ { "id": "cd79b", "kind": "target", "name": "CD79b", "url": "https://onco.cc/targets/cd79b/" }, { "id": "epcoritamab", "kind": "drug", "name": "Epcoritamab", "url": "https://onco.cc/drugs/epcoritamab/" }, { "id": "mosunetuzumab", "kind": "drug", "name": "Mosunetuzumab", "url": "https://onco.cc/drugs/mosunetuzumab/" }, { "id": "polatuzumab-vedotin", "kind": "drug", "name": "Polatuzumab vedotin", "url": "https://onco.cc/drugs/polatuzumab-vedotin/" }, { "id": "tafasitamab", "kind": "drug", "name": "Tafasitamab", "url": "https://onco.cc/drugs/tafasitamab/" } ] } }, { "id": "https://doi.org/10.1093/nar/gkag1009#onco-edge-paper", "url": "https://doi.org/10.1093/nar/gkag1009", "title": "OAS-nano: the Observed VHH Space Database.", "content_text": "Published in Nucleic Acids Res on 15 October 2026; matched the OnCo record for CTAG2.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Nucleic Acids Res", "doi": "10.1093/nar/gkag1009", "records": [ { "id": "ctag2", "kind": "target", "name": "CTAG2", "url": "https://onco.cc/targets/ctag2/" } ] } }, { "id": "https://doi.org/10.1080/10428194.2026.2747547#onco-edge-paper", "url": "https://doi.org/10.1080/10428194.2026.2747547", "title": "Oral azacitidine as time-limited, PCR-dependent maintenance in acute myeloid leukemia with inv(16): two case reports.", "content_text": "Published in Leuk Lymphoma on 15 October 2026; matched the OnCo record for CBFB.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Leuk Lymphoma", "doi": "10.1080/10428194.2026.2747547", "records": [ { "id": "cbfb", "kind": "target", "name": "CBFB", "url": "https://onco.cc/targets/cbfb/" }, { "id": "myh11", "kind": "target", "name": "MYH11", "url": "https://onco.cc/targets/myh11/" } ] } }, { "id": "https://doi.org/10.1080/10717544.2026.2741456#onco-edge-paper", "url": "https://doi.org/10.1080/10717544.2026.2741456", "title": "Overcoming the nuclear barrier in nonviral gene therapy: mechanisms, carrier design, and translational perspectives on NLS peptide and DNA targeting sequence strategies.", "content_text": "Published in Drug Deliv on 15 October 2026; matched the OnCo record for Nogapendekin alfa inbakicept.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Drug Deliv", "doi": "10.1080/10717544.2026.2741456", "records": [ { "id": "nogapendekin-alfa", "kind": "drug", "name": "Nogapendekin alfa inbakicept", "url": "https://onco.cc/drugs/nogapendekin-alfa/" } ] } }, { "id": "https://doi.org/10.1242/jcs.265172#onco-edge-paper", "url": "https://doi.org/10.1242/jcs.265172", "title": "Pharmacological inhibition of MCL-1 disrupts mitochondrial cristae and depletes the human neural progenitor cell pool.", "content_text": "Published in J Cell Sci on 15 October 2026; matched the OnCo record for MED12.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Cell Sci", "doi": "10.1242/jcs.265172", "records": [ { "id": "med12", "kind": "target", "name": "MED12", "url": "https://onco.cc/targets/med12/" } ] } }, { "id": "https://doi.org/10.1016/j.jmgm.2026.109594#onco-edge-paper", "url": "https://doi.org/10.1016/j.jmgm.2026.109594", "title": "Pharmacophore modelling-based screening of natural allosteric EGFR inhibitors using molecular docking, DFT, and molecular dynamics simulations.", "content_text": "Published in J Mol Graph Model on 15 October 2026; matched the OnCo record for Cetuximab.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Mol Graph Model", "doi": "10.1016/j.jmgm.2026.109594", "records": [ { "id": "cetuximab", "kind": "drug", "name": "Cetuximab", "url": "https://onco.cc/drugs/cetuximab/" } ] } }, { "id": "https://doi.org/10.1016/j.pbi.2026.102981#onco-edge-paper", "url": "https://doi.org/10.1016/j.pbi.2026.102981", "title": "Plant DICER-LIKE, dual measurement RNA rulers.", "content_text": "Published in Curr Opin Plant Biol on 15 October 2026; matched the OnCo record for DICER1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Curr Opin Plant Biol", "doi": "10.1016/j.pbi.2026.102981", "records": [ { "id": "dicer1", "kind": "target", "name": "DICER1", "url": "https://onco.cc/targets/dicer1/" } ] } }, { "id": "https://doi.org/10.1016/j.transproceed.2026.09.018#onco-edge-paper", "url": "https://doi.org/10.1016/j.transproceed.2026.09.018", "title": "Post-Transplant Lymphoproliferative Disorder After Successful Treatment of Graft-Versus Host Disease Following Liver Transplantation.", "content_text": "Published in Transplant Proc on 15 October 2026; matched the OnCo record for Post-transplant lymphoproliferative disorder.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Transplant Proc", "doi": "10.1016/j.transproceed.2026.09.018", "records": [ { "id": "post-transplant-lymphoproliferative-disorder", "kind": "cancer", "name": "Post-transplant lymphoproliferative disorder", "url": "https://onco.cc/cancers/post-transplant-lymphoproliferative-disorder/" } ] } }, { "id": "https://doi.org/10.1080/03630269.2026.2725724#onco-edge-paper", "url": "https://doi.org/10.1080/03630269.2026.2725724", "title": "Precision Medicine in Sickle Cell Disease: From Molecular Pathways to Curative Strategies.", "content_text": "Published in Hemoglobin on 15 October 2026; matched the OnCo record for BCL11A.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Hemoglobin", "doi": "10.1080/03630269.2026.2725724", "records": [ { "id": "bcl11a", "kind": "target", "name": "BCL11A", "url": "https://onco.cc/targets/bcl11a/" }, { "id": "myb", "kind": "target", "name": "MYB", "url": "https://onco.cc/targets/myb/" }, { "id": "mybl1", "kind": "target", "name": "MYBL1", "url": "https://onco.cc/targets/mybl1/" } ] } }, { "id": "https://doi.org/10.1038/s41416-026-03634-4#onco-edge-paper", "url": "https://doi.org/10.1038/s41416-026-03634-4", "title": "Preclinical efficacy of a systemically-administered, second-generation STING agonist that promotes anti-tumour immunity in combination with radiotherapy.", "content_text": "Published on 15 October 2026 after first appearing as a preprint; matched Immune checkpoint inhibitors, STING & innate immune agonists and PD-1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "doi": "10.1038/s41416-026-03634-4", "records": [ { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" }, { "id": "sting-agonist", "kind": "technology", "name": "STING & innate immune agonists", "url": "https://onco.cc/technologies/sting-agonist/" }, { "id": "pd1", "kind": "target", "name": "PD-1", "url": "https://onco.cc/targets/pd1/" }, { "id": "pdl1", "kind": "target", "name": "PD-L1", "url": "https://onco.cc/targets/pdl1/" }, { "id": "ctla4", "kind": "target", "name": "CTLA-4", "url": "https://onco.cc/targets/ctla4/" }, { "id": "cd8", "kind": "target", "name": "CD8", "url": "https://onco.cc/targets/cd8/" } ] } }, { "id": "https://doi.org/10.1016/j.xcrm.2026.103114#onco-edge-paper", "url": "https://doi.org/10.1016/j.xcrm.2026.103114", "title": "Prediction of immunotherapy response using live tumor fragments from routine clinical biopsies.", "content_text": "Published in Cell Rep Med on 15 October 2026; matched the OnCo record for Companion diagnostics.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Cell Rep Med", "doi": "10.1016/j.xcrm.2026.103114", "records": [ { "id": "companion-diagnostic", "kind": "technology", "name": "Companion diagnostics", "url": "https://onco.cc/technologies/companion-diagnostic/" }, { "id": "checkpoint-inhibitor", "kind": "technology", "name": "Immune checkpoint inhibitors", "url": "https://onco.cc/technologies/checkpoint-inhibitor/" } ] } }, { "id": "https://doi.org/10.1245/s10434-026-20718-w#onco-edge-paper", "url": "https://doi.org/10.1245/s10434-026-20718-w", "title": "Prefoldin Subunit 2 Promotes Migration of Hepatocellular Carcinoma Cells and Is Associated with Poor Prognosis.", "content_text": "Published in Ann Surg Oncol on 15 October 2026; matched the OnCo record for HLF.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Ann Surg Oncol", "doi": "10.1245/s10434-026-20718-w", "records": [ { "id": "hlf", "kind": "target", "name": "HLF", "url": "https://onco.cc/targets/hlf/" }, { "id": "rac1", "kind": "target", "name": "RAC1", "url": "https://onco.cc/targets/rac1/" } ] } }, { "id": "https://doi.org/10.1002/iju5.70282#onco-edge-paper", "url": "https://doi.org/10.1002/iju5.70282", "title": "Primary Pure Yolk Sac Tumor of the Urinary Bladder: A Case Report.", "content_text": "Published in IJU Case Rep on 15 October 2026; matched the OnCo record for Etoposide.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "IJU Case Rep", "doi": "10.1002/iju5.70282", "records": [ { "id": "etoposide", "kind": "drug", "name": "Etoposide", "url": "https://onco.cc/drugs/etoposide/" }, { "id": "gpc3", "kind": "target", "name": "Glypican-3", "url": "https://onco.cc/targets/gpc3/" }, { "id": "sall4", "kind": "target", "name": "SALL4", "url": "https://onco.cc/targets/sall4/" }, { "id": "yolk-sac-tumour-postpubertal", "kind": "cancer", "name": "Yolk sac tumour of the testis, postpubertal type", "url": "https://onco.cc/cancers/yolk-sac-tumour-postpubertal/" } ] } }, { "id": "https://doi.org/10.1182/bloodadvances.2026021259#onco-edge-paper", "url": "https://doi.org/10.1182/bloodadvances.2026021259", "title": "Prognosis and treatment-related toxicities in Down syndrome acute lymphoblastic leukemia in JCCG ALL-B12.", "content_text": "Published in Blood Adv on 15 October 2026; matched the OnCo record for CRLF2.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Blood Adv", "doi": "10.1182/bloodadvances.2026021259", "records": [ { "id": "crlf2", "kind": "target", "name": "CRLF2", "url": "https://onco.cc/targets/crlf2/" } ] } }, { "id": "https://doi.org/10.1038/s44321-026-00533-2#onco-edge-paper", "url": "https://doi.org/10.1038/s44321-026-00533-2", "title": "PTEN-loss confers dependence on the guanylate synthesis enzyme IMPDH in T-cell acute lymphoblastic leukemia.", "content_text": "Published on 15 October 2026 after first appearing as a preprint; matched AKT and PTEN.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "doi": "10.1038/s44321-026-00533-2", "records": [ { "id": "akt", "kind": "target", "name": "AKT", "url": "https://onco.cc/targets/akt/" }, { "id": "pten", "kind": "target", "name": "PTEN", "url": "https://onco.cc/targets/pten/" } ] } }, { "id": "https://doi.org/10.1016/j.imbio.2026.153258#onco-edge-paper", "url": "https://doi.org/10.1016/j.imbio.2026.153258", "title": "Putrescine alters the composition of interstitial dendritic cell subsets by suppressing Cybb-dependent oxidative phosphorylation.", "content_text": "Published in Immunobiology on 15 October 2026; matched the OnCo record for POLD1.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Immunobiology", "doi": "10.1016/j.imbio.2026.153258", "records": [ { "id": "pold1", "kind": "target", "name": "POLD1", "url": "https://onco.cc/targets/pold1/" } ] } }, { "id": "https://doi.org/10.1111/jdv.70807#onco-edge-paper", "url": "https://doi.org/10.1111/jdv.70807", "title": "Real-world comparison of sonidegib and vismodegib in advanced basal cell carcinoma.", "content_text": "Published in J Eur Acad Dermatol Venereol on 15 October 2026; matched the OnCo record for Locally advanced and metastatic basal cell carcinoma.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Eur Acad Dermatol Venereol", "doi": "10.1111/jdv.70807", "records": [ { "id": "locally-advanced-bcc", "kind": "cancer", "name": "Locally advanced and metastatic basal cell carcinoma", "url": "https://onco.cc/cancers/locally-advanced-bcc/" }, { "id": "sonidegib", "kind": "drug", "name": "Sonidegib", "url": "https://onco.cc/drugs/sonidegib/" }, { "id": "vismodegib", "kind": "drug", "name": "Vismodegib", "url": "https://onco.cc/drugs/vismodegib/" } ] } }, { "id": "https://doi.org/10.1002/jha2.70384#onco-edge-paper", "url": "https://doi.org/10.1002/jha2.70384", "title": "Real-World Treatment Patterns, Burden of Illness, and Survival of Autologous Stem Cell Transplant-Ineligible Patients With Mantle Cell Lymphoma in Ontario, Canada.", "content_text": "Published in EJHaem on 15 October 2026; matched the OnCo record for Autologous stem cell transplant.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "EJHaem", "doi": "10.1002/jha2.70384", "records": [ { "id": "autologous-stem-cell-transplant", "kind": "technology", "name": "Autologous stem cell transplant", "url": "https://onco.cc/technologies/autologous-stem-cell-transplant/" }, { "id": "bendamustine", "kind": "drug", "name": "Bendamustine", "url": "https://onco.cc/drugs/bendamustine/" } ] } }, { "id": "https://doi.org/10.1097/mph.0000000000003302#onco-edge-paper", "url": "https://doi.org/10.1097/mph.0000000000003302", "title": "Real-World Use of Dinutuximab Beta for High-Risk Neuroblastoma in Clinical Settings in France: The QUATUOR Study.", "content_text": "Published in J Pediatr Hematol Oncol on 15 October 2026; matched the OnCo record for Dinutuximab (ch14.18) / dinutuximab beta.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "J Pediatr Hematol Oncol", "doi": "10.1097/mph.0000000000003302", "records": [ { "id": "dinutuximab", "kind": "drug", "name": "Dinutuximab (ch14.18) / dinutuximab beta", "url": "https://onco.cc/drugs/dinutuximab/" } ] } }, { "id": "https://doi.org/10.1111/bjh.70887#onco-edge-paper", "url": "https://doi.org/10.1111/bjh.70887", "title": "Reduced-dose pegylated asparaginase reliably achieves therapeutic levels in adult patients with acute lymphoblastic leukaemia and lymphoblastic lymphoma.", "content_text": "Published in Br J Haematol on 15 October 2026; matched the OnCo record for Acute lymphoblastic leukaemia.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Br J Haematol", "doi": "10.1111/bjh.70887", "records": [ { "id": "all-leukemia", "kind": "cancer", "name": "Acute lymphoblastic leukaemia", "url": "https://onco.cc/cancers/all-leukemia/" }, { "id": "asparaginase", "kind": "drug", "name": "Asparaginase", "url": "https://onco.cc/drugs/asparaginase/" } ] } }, { "id": "https://doi.org/10.2169/internalmedicine.8128-26#onco-edge-paper", "url": "https://doi.org/10.2169/internalmedicine.8128-26", "title": "Response to Venetoclax and Azacitidine in Induction-Refractory Adult Acute Myeloid Leukemia with UBTF Tandem Duplication and Associated Aberrant Splicing: A Case Report.", "content_text": "Published in Intern Med on 15 October 2026; matched the OnCo record for UBTF.", "date_published": "2026-10-15T00:00:00Z", "tags": [ "paper" ], "_onco": { "kind": "paper", "date": "2026-10-15", "precision": "day", "venue": "Intern Med", "doi": "10.2169/internalmedicine.8128-26", "records": [ { "id": "ubtf", "kind": "target", "name": "UBTF", "url": "https://onco.cc/targets/ubtf/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-belzutifan-combination-lenvatinib-advanced-renal-cell-carcinoma-clear-cell-component#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-belzutifan-combination-lenvatinib-advanced-renal-cell-carcinoma-clear-cell-component", "title": "FDA approves belzutifan in combination with lenvatinib for advanced renal cell carcinoma with a clear cell component", "content_text": "On September 24, 2026, the Food and Drug Administration approved belzutifan (Welireg, Merck & Co., Inc.) in combination with lenvatinib (Lenvima, Eisai Inc.) for adults with advanced renal cell carcinoma with a clear cell component (ccRCC) following a programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor.", "date_published": "2026-09-24T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-09-24", "precision": "day", "venue": "FDA", "records": [ { "id": "lenvatinib", "kind": "drug", "name": "Lenvatinib", "url": "https://onco.cc/drugs/lenvatinib/" }, { "id": "belzutifan", "kind": "drug", "name": "Belzutifan", "url": "https://onco.cc/drugs/belzutifan/" }, { "id": "rcc", "kind": "cancer", "name": "Renal cell carcinoma", "url": "https://onco.cc/cancers/rcc/" }, { "id": "clear-cell-rcc", "kind": "cancer", "name": "Clear cell renal cell carcinoma", "url": "https://onco.cc/cancers/clear-cell-rcc/" }, { "id": "spinal-cord-tumours", "kind": "cancer", "name": "Spinal cord tumours", "url": "https://onco.cc/cancers/spinal-cord-tumours/" }, { "id": "pancreatic-net", "kind": "cancer", "name": "Pancreatic neuroendocrine tumours", "url": "https://onco.cc/cancers/pancreatic-net/" }, { "id": "hereditary-ppgl", "kind": "cancer", "name": "Hereditary pheochromocytoma and paraganglioma", "url": "https://onco.cc/cancers/hereditary-ppgl/" }, { "id": "hcc", "kind": "cancer", "name": "Hepatocellular carcinoma", "url": "https://onco.cc/cancers/hcc/" }, { "id": "hcc-advanced", "kind": "cancer", "name": "Advanced hepatocellular carcinoma", "url": "https://onco.cc/cancers/hcc-advanced/" }, { "id": "hcc-intermediate", "kind": "cancer", "name": "Intermediate hepatocellular carcinoma", "url": "https://onco.cc/cancers/hcc-intermediate/" }, { "id": "thyroid", "kind": "cancer", "name": "Thyroid cancer", "url": "https://onco.cc/cancers/thyroid/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lirafugratinib-previously-treated-unresectable-locally-advanced-or-metastatic#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-lirafugratinib-previously-treated-unresectable-locally-advanced-or-metastatic", "title": "FDA approves lirafugratinib for previously treated, unresectable, locally advanced or metastatic cholangiocarcinoma", "content_text": "On September 23, 2026, the Food and Drug Administration approved lirafugratinib (Lyrfigtu, Elevar Therapeutics, Inc.), a kinase inhibitor, for the treatment of adults with previously treated unresectable, locally advanced or metastatic cholangiocarcinoma harboring a fibroblast growth factor receptor 2 (FGFR2) gene fusion or other rearrangement.", "date_published": "2026-09-23T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-09-23", "precision": "day", "venue": "FDA", "records": [ { "id": "lirafugratinib", "kind": "drug", "name": "Lirafugratinib", "url": "https://onco.cc/drugs/lirafugratinib/" }, { "id": "cholangiocarcinoma", "kind": "cancer", "name": "Biliary tract cancer", "url": "https://onco.cc/cancers/cholangiocarcinoma/" }, { "id": "fgfr2", "kind": "target", "name": "FGFR2", "url": "https://onco.cc/targets/fgfr2/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-imlunestrant-combination-abemaciclib-er-positive-her2-negative-esr1-mutated-advanced-or#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-imlunestrant-combination-abemaciclib-er-positive-her2-negative-esr1-mutated-advanced-or", "title": "FDA approves imlunestrant in combination with abemaciclib for ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer", "content_text": "On September 18, 2026, the Food and Drug Administration approved imlunestrant (Inluriyo) in combination with abemaciclib (Verzenio), for adults with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, estrogen receptor 1 (ESR1)-mutated advanced or metastatic breast cancer, as detected by an FDA-authorized test, with disease progression following at least one line of endocrine therapy.", "date_published": "2026-09-18T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-09-18", "precision": "day", "venue": "FDA", "records": [ { "id": "imlunestrant", "kind": "drug", "name": "Imlunestrant", "url": "https://onco.cc/drugs/imlunestrant/" }, { "id": "abemaciclib", "kind": "drug", "name": "Abemaciclib", "url": "https://onco.cc/drugs/abemaciclib/" }, { "id": "breast-hr-positive", "kind": "cancer", "name": "HR-positive / HER2-negative breast cancer", "url": "https://onco.cc/cancers/breast-hr-positive/" }, { "id": "breast-cancer", "kind": "cancer", "name": "Breast cancer", "url": "https://onco.cc/cancers/breast-cancer/" }, { "id": "hr-positive-early-high-risk", "kind": "cancer", "name": "High-risk early HR-positive breast cancer", "url": "https://onco.cc/cancers/hr-positive-early-high-risk/" }, { "id": "hr-positive-metastatic-post-cdk46", "kind": "cancer", "name": "HR-positive metastatic breast cancer after CDK4/6 inhibitors", "url": "https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/" }, { "id": "cdk4-6", "kind": "target", "name": "CDK4/6", "url": "https://onco.cc/targets/cdk4-6/" }, { "id": "estrogen-receptor", "kind": "target", "name": "Estrogen receptor", "url": "https://onco.cc/targets/estrogen-receptor/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-sevabertinib-locally-advanced-or-metastatic-non-squamous-non-small#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-sevabertinib-locally-advanced-or-metastatic-non-squamous-non-small", "title": "FDA grants accelerated approval to sevabertinib for locally advanced or metastatic non-squamous non-small cell lung cancer", "content_text": "On September 9, 2026, the Food and Drug Administration granted accelerated approval to sevabertinib (Hyrnuo, Bayer Healthcare Pharmaceuticals Inc.), a kinase inhibitor, for adult patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC) whose tumors have HER2 (ERBB2) tyrosine kinase domain (TKD) activating mutations, as detected by an FDA-authorized test.", "date_published": "2026-09-09T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-09-09", "precision": "day", "venue": "FDA", "records": [ { "id": "sevabertinib", "kind": "drug", "name": "Sevabertinib", "url": "https://onco.cc/drugs/sevabertinib/" }, { "id": "lung-cancer", "kind": "cancer", "name": "Lung cancer", "url": "https://onco.cc/cancers/lung-cancer/" }, { "id": "lung-squamous-cell-carcinoma", "kind": "cancer", "name": "Squamous cell carcinoma of the lung", "url": "https://onco.cc/cancers/lung-squamous-cell-carcinoma/" }, { "id": "nsclc", "kind": "cancer", "name": "Non-small-cell lung cancer", "url": "https://onco.cc/cancers/nsclc/" }, { "id": "her2-mutant-nsclc", "kind": "cancer", "name": "HER2-mutant non-small-cell lung cancer", "url": "https://onco.cc/cancers/her2-mutant-nsclc/" }, { "id": "her2", "kind": "target", "name": "HER2", "url": "https://onco.cc/targets/her2/" } ] } }, { "id": "https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-new-breast-cancer-treatment#onco-edge-approval", "url": "https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-new-breast-cancer-treatment", "title": "Accelerated approval: Camizestrant (US)", "content_text": "Accelerated approval (Etcamah) The confirmatory requirement was still open 0.0 years later, when the FDA's table was read.", "date_published": "2026-09-04T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-09-04", "precision": "day", "venue": "FDA", "records": [ { "id": "camizestrant", "kind": "drug", "name": "Camizestrant", "url": "https://onco.cc/drugs/camizestrant/" }, { "id": "breast-hr-positive", "kind": "cancer", "name": "HR-positive / HER2-negative breast cancer", "url": "https://onco.cc/cancers/breast-hr-positive/" }, { "id": "hr-positive-metastatic-post-cdk46", "kind": "cancer", "name": "HR-positive metastatic breast cancer after CDK4/6 inhibitors", "url": "https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/" }, { "id": "estrogen-receptor", "kind": "target", "name": "Estrogen receptor", "url": "https://onco.cc/targets/estrogen-receptor/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-camizestrant-cdk46-inhibitor-esr1-mutated-hr-positive-her2-negative#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-camizestrant-cdk46-inhibitor-esr1-mutated-hr-positive-her2-negative", "title": "FDA grants accelerated approval to camizestrant with a CDK4/6 inhibitor for ESR1-Mutated HR-positive, HER2-negative locally advanced or metastatic breast cancer", "content_text": "On September 4, 2026, the Food and Drug Administration granted accelerated approval to camizestrant (Etcamah, AstraZeneca), an estrogen receptor antagonist, in combination with a CDK4/6 inhibitor (abemaciclib, palbociclib, or ribociclib) for adults with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer upon detection of estrogen receptor-1 (ESR1) mutation during aromatase inhibitor and CDK4/6 inhibitor therapy, based on an FDA-authorized test.", "date_published": "2026-09-04T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-09-04", "precision": "day", "venue": "FDA", "records": [ { "id": "camizestrant", "kind": "drug", "name": "Camizestrant", "url": "https://onco.cc/drugs/camizestrant/" }, { "id": "palbociclib", "kind": "drug", "name": "Palbociclib", "url": "https://onco.cc/drugs/palbociclib/" }, { "id": "abemaciclib", "kind": "drug", "name": "Abemaciclib", "url": "https://onco.cc/drugs/abemaciclib/" }, { "id": "ribociclib", "kind": "drug", "name": "Ribociclib", "url": "https://onco.cc/drugs/ribociclib/" }, { "id": "breast-cancer", "kind": "cancer", "name": "Breast cancer", "url": "https://onco.cc/cancers/breast-cancer/" }, { "id": "breast-hr-positive", "kind": "cancer", "name": "HR-positive / HER2-negative breast cancer", "url": "https://onco.cc/cancers/breast-hr-positive/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-adagrasib-cetuximab-kras-g12c-mutated-colorectal-cancer#onco-edge-withdrawal", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-adagrasib-cetuximab-kras-g12c-mutated-colorectal-cancer", "title": "Withdrawal: Adagrasib (US)", "content_text": "Withdrawn: the indication came off the label 2.3 years after its accelerated approval.", "date_published": "2026-09-01T00:00:00Z", "tags": [ "withdrawal" ], "_onco": { "kind": "withdrawal", "date": "2026-09-01", "precision": "day", "venue": "FDA", "records": [ { "id": "adagrasib", "kind": "drug", "name": "Adagrasib", "url": "https://onco.cc/drugs/adagrasib/" }, { "id": "nsclc", "kind": "cancer", "name": "Non-small-cell lung cancer", "url": "https://onco.cc/cancers/nsclc/" }, { "id": "colorectal", "kind": "cancer", "name": "Colorectal cancer", "url": "https://onco.cc/cancers/colorectal/" }, { "id": "pancreatic", "kind": "cancer", "name": "Pancreatic ductal adenocarcinoma", "url": "https://onco.cc/cancers/pancreatic/" }, { "id": "kras-g12c-colorectal", "kind": "cancer", "name": "KRAS G12C-mutant colorectal cancer", "url": "https://onco.cc/cancers/kras-g12c-colorectal/" }, { "id": "kras-g12c-nsclc", "kind": "cancer", "name": "KRAS G12C-mutant non-small-cell lung cancer", "url": "https://onco.cc/cancers/kras-g12c-nsclc/" } ] } }, { "id": "https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2026/220910Orig1s000ltr.pdf#onco-edge-approval", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2026/220910Orig1s000ltr.pdf", "title": "Approval: Daraxonrasib (US)", "content_text": "NDA 220910 approved as Rasonque: adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or who are not candidates for multiagent systemic therapy.", "date_published": "2026-08-26T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-08-26", "precision": "day", "venue": "FDA", "records": [ { "id": "daraxonrasib", "kind": "drug", "name": "Daraxonrasib", "url": "https://onco.cc/drugs/daraxonrasib/" }, { "id": "pancreatic", "kind": "cancer", "name": "Pancreatic ductal adenocarcinoma", "url": "https://onco.cc/cancers/pancreatic/" }, { "id": "metastatic-pdac", "kind": "cancer", "name": "Metastatic pancreatic ductal adenocarcinoma", "url": "https://onco.cc/cancers/metastatic-pdac/" }, { "id": "kras-g12c-pdac", "kind": "cancer", "name": "KRAS G12C-mutant pancreatic ductal adenocarcinoma", "url": "https://onco.cc/cancers/kras-g12c-pdac/" }, { "id": "nsclc", "kind": "cancer", "name": "Non-small-cell lung cancer", "url": "https://onco.cc/cancers/nsclc/" }, { "id": "colorectal", "kind": "cancer", "name": "Colorectal cancer", "url": "https://onco.cc/cancers/colorectal/" } ] } }, { "id": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-daraxonrasib-metastatic-pancreatic-adenocarcinoma#onco-edge-approval", "url": "https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-daraxonrasib-metastatic-pancreatic-adenocarcinoma", "title": "FDA approves daraxonrasib for metastatic pancreatic adenocarcinoma", "content_text": "On August 26, 2026, the Food and Drug Administration approved daraxonrasib (RASONQUE, Revolution Medicines, Inc.), an inhibitor of the RAS GTPase family, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or who are not candidates for multiagent systemic therapy.", "date_published": "2026-08-26T00:00:00Z", "tags": [ "approval" ], "_onco": { "kind": "approval", "date": "2026-08-26", "precision": "day", "venue": "FDA", "records": [ { "id": "daraxonrasib", "kind": "drug", "name": "Daraxonrasib", "url": "https://onco.cc/drugs/daraxonrasib/" }, { "id": "pancreatic", "kind": "cancer", "name": "Pancreatic ductal adenocarcinoma", "url": "https://onco.cc/cancers/pancreatic/" }, { "id": "urethral-adenocarcinoma", "kind": "cancer", "name": "Adenocarcinoma of the urethra", "url": "https://onco.cc/cancers/urethral-adenocarcinoma/" }, { "id": "lung-adenocarcinoma", "kind": "cancer", "name": "Adenocarcinoma of the lung", "url": "https://onco.cc/cancers/lung-adenocarcinoma/" } ] } }, { "id": "https://wayback.archive-it.org/7993/20201222063544/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tazemetostat-advanced-epithelioid-sarcoma#onco-edge-withdrawal", "url": "https://wayback.archive-it.org/7993/20201222063544/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-tazemetostat-advanced-epithelioid-sarcoma", "title": "Withdrawal: Tazemetostat (US)", "content_text": "Withdrawn: the indication came off the label 6.4 years after its accelerated approval.", "date_published": "2026-06-22T00:00:00Z", "tags": [ "withdrawal" ], "_onco": { "kind": "withdrawal", "date": "2026-06-22", "precision": "day", "venue": "FDA", "records": [ { "id": "tazemetostat", "kind": "drug", "name": "Tazemetostat", "url": "https://onco.cc/drugs/tazemetostat/" }, { "id": "follicular-lymphoma", "kind": "cancer", "name": "Follicular lymphoma", "url": "https://onco.cc/cancers/follicular-lymphoma/" }, { "id": "sarcoma", "kind": "cancer", "name": "Sarcomas", "url": "https://onco.cc/cancers/sarcoma/" }, { "id": "ezh2", "kind": "target", "name": "EZH2", "url": "https://onco.cc/targets/ezh2/" } ] } }, { "id": "https://wayback.archive-it.org/7993/20201222062826/https:/www.fda.gov/drugs/fda-granted-accelerated-approval-tazemetostat-follicular-lymphoma#onco-edge-withdrawal", "url": "https://wayback.archive-it.org/7993/20201222062826/https:/www.fda.gov/drugs/fda-granted-accelerated-approval-tazemetostat-follicular-lymphoma", "title": "Withdrawal: Tazemetostat (US)", "content_text": "Withdrawn: the indication came off the label 6.0 years after its accelerated approval.", "date_published": "2026-06-22T00:00:00Z", "tags": [ "withdrawal" ], "_onco": { "kind": "withdrawal", "date": "2026-06-22", "precision": "day", "venue": "FDA", "records": [ { "id": "tazemetostat", "kind": "drug", "name": "Tazemetostat", "url": "https://onco.cc/drugs/tazemetostat/" }, { "id": "follicular-lymphoma", "kind": "cancer", "name": "Follicular lymphoma", "url": "https://onco.cc/cancers/follicular-lymphoma/" }, { "id": "sarcoma", "kind": "cancer", "name": "Sarcomas", "url": "https://onco.cc/cancers/sarcoma/" }, { "id": "ezh2", "kind": "target", "name": "EZH2", "url": "https://onco.cc/targets/ezh2/" } ] } }, { "id": "https://wayback.archive-it.org/7993/20201222062817/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma#onco-edge-withdrawal", "url": "https://wayback.archive-it.org/7993/20201222062817/https:/www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-selinexor-relapsedrefractory-diffuse-large-b-cell-lymphoma", "title": "Withdrawal: Selinexor (US)", "content_text": "Withdrawn: the indication came off the label 5.9 years after its accelerated approval.", "date_published": "2026-04-30T00:00:00Z", "tags": [ "withdrawal" ], "_onco": { "kind": "withdrawal", "date": "2026-04-30", "precision": "day", "venue": "FDA", "records": [ { "id": "selinexor", "kind": "drug", "name": "Selinexor", "url": "https://onco.cc/drugs/selinexor/" }, { "id": "endometrial", "kind": "cancer", "name": "Endometrial cancer", "url": "https://onco.cc/cancers/endometrial/" }, { "id": "multiple-myeloma", "kind": "cancer", "name": "Multiple myeloma", "url": "https://onco.cc/cancers/multiple-myeloma/" }, { "id": "dlbcl", "kind": "cancer", "name": "Diffuse large B-cell lymphoma", "url": "https://onco.cc/cancers/dlbcl/" }, { "id": "myeloma-relapsed-refractory", "kind": "cancer", "name": "Relapsed or refractory multiple myeloma", "url": "https://onco.cc/cancers/myeloma-relapsed-refractory/" }, { "id": "tp53", "kind": "target", "name": "TP53", "url": "https://onco.cc/targets/tp53/" } ] } }, { "id": "https://www.oncologypipeline.com/apexonco/bicycle-finally-falls#onco-edge-withdrawal", "url": "https://www.oncologypipeline.com/apexonco/bicycle-finally-falls", "title": "Withdrawal: Zelenectide pevedotin (US)", "content_text": "Programme deprioritised after regulatory feedback on Duravelo-2 design.", "date_published": "2026-03-01T00:00:00Z", "tags": [ "withdrawal" ], "_onco": { "kind": "withdrawal", "date": "2026-03", "precision": "month", "venue": "FDA", "records": [ { "id": "zelenectide-pevedotin", "kind": "drug", "name": "Zelenectide pevedotin", "url": "https://onco.cc/drugs/zelenectide-pevedotin/" }, { "id": "urothelial", "kind": "cancer", "name": "Bladder & urothelial cancer", "url": "https://onco.cc/cancers/urothelial/" }, { "id": "nectin4", "kind": "target", "name": "Nectin-4", "url": "https://onco.cc/targets/nectin4/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT05388669?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT05388669?tab=results", "title": "A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor: Phase 3 result", "content_text": "For All Regions Other Than the European Union (EU) and Others Accepting Cycle 2 Day 1: Observed Serum Concentration (Ctrough) of Amivantamab at Steady State: Arm A: Lazertinib With Amivantamab SC-CF 206 micrograms per milliliters (mcg/ml) versus Arm B: Lazertinib With Amivantamab Intravenous (IV) Infusion 144 micrograms per milliliters (mcg/ml).", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct05388669", "kind": "trial", "name": "A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor", "url": "https://onco.cc/trials/nct05388669/" }, { "id": "lazertinib", "kind": "drug", "name": "Lazertinib", "url": "https://onco.cc/drugs/lazertinib/" }, { "id": "nsclc", "kind": "cancer", "name": "Non-small-cell lung cancer", "url": "https://onco.cc/cancers/nsclc/" }, { "id": "egfr-mutant-nsclc", "kind": "cancer", "name": "EGFR-mutated non-small-cell lung cancer", "url": "https://onco.cc/cancers/egfr-mutant-nsclc/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT04497844?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT04497844?tab=results", "title": "A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair: Phase 3 result", "content_text": "Breast Cancer Gene (BRCA) Subgroup: Radiographic Progression-free Survival (rPFS) Assessed by Investigator: BRCA Subgroup: Placebo With Abiraterone Acetate Plus Prednisone 25.99 months, hazard ratio 0.515.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct04497844", "kind": "trial", "name": "A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair", "url": "https://onco.cc/trials/nct04497844/" }, { "id": "abiraterone", "kind": "drug", "name": "Abiraterone acetate", "url": "https://onco.cc/drugs/abiraterone/" }, { "id": "niraparib", "kind": "drug", "name": "Niraparib", "url": "https://onco.cc/drugs/niraparib/" }, { "id": "prednisone", "kind": "drug", "name": "Prednisone", "url": "https://onco.cc/drugs/prednisone/" }, { "id": "prostate", "kind": "cancer", "name": "Prostate cancer", "url": "https://onco.cc/cancers/prostate/" }, { "id": "prostate-mhspc", "kind": "cancer", "name": "Metastatic hormone-sensitive prostate cancer", "url": "https://onco.cc/cancers/prostate-mhspc/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT04194775?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT04194775?tab=results", "title": "A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma: Phase 3 result", "content_text": "Overall Survival (OS): Nofazinlimab + Lenvatinib 21.6 months versus Placebo + Lenvatinib 18.5 months.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct04194775", "kind": "trial", "name": "A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma", "url": "https://onco.cc/trials/nct04194775/" }, { "id": "lenvatinib", "kind": "drug", "name": "Lenvatinib", "url": "https://onco.cc/drugs/lenvatinib/" }, { "id": "hcc", "kind": "cancer", "name": "Hepatocellular carcinoma", "url": "https://onco.cc/cancers/hcc/" }, { "id": "hcc-advanced", "kind": "cancer", "name": "Advanced hepatocellular carcinoma", "url": "https://onco.cc/cancers/hcc-advanced/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT04351555?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT04351555?tab=results", "title": "A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-S: Phase 3 result", "content_text": "Major Pathological Response (MPR) - IASLC Method: Osimertinib + Chemo 25.6 % versus Osimertinib 24.8 % versus Placebo + Chemo 1.7 %.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct04351555", "kind": "trial", "name": "A Study of Osimertinib With or Without Chemotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for Patients With EGFRm Positive Resectable Non-S", "url": "https://onco.cc/trials/nct04351555/" }, { "id": "osimertinib", "kind": "drug", "name": "Osimertinib", "url": "https://onco.cc/drugs/osimertinib/" }, { "id": "cisplatin", "kind": "drug", "name": "Cisplatin", "url": "https://onco.cc/drugs/cisplatin/" }, { "id": "carboplatin", "kind": "drug", "name": "Carboplatin", "url": "https://onco.cc/drugs/carboplatin/" }, { "id": "pemetrexed", "kind": "drug", "name": "Pemetrexed", "url": "https://onco.cc/drugs/pemetrexed/" }, { "id": "nsclc", "kind": "cancer", "name": "Non-small-cell lung cancer", "url": "https://onco.cc/cancers/nsclc/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT05625399?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT05625399?tab=results", "title": "A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma: Phase 3 result", "content_text": "Adjusted Time-Averaged Nivolumab Serum Concentration Over the First 28 Days (Cavgd28-Nivo) on Natural Logarithmic Scale: Nivo + Rela FDC SC 4.141 ug/ml versus Nivo + Rela FDC IV 3.901 ug/ml.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct05625399", "kind": "trial", "name": "A Study of Subcutaneous Nivolumab + Relatlimab Fixed-dose Combination (FDC) in Previously Untreated Metastatic or Unresectable Melanoma", "url": "https://onco.cc/trials/nct05625399/" }, { "id": "nivolumab", "kind": "drug", "name": "Nivolumab", "url": "https://onco.cc/drugs/nivolumab/" }, { "id": "relatlimab-nivolumab", "kind": "drug", "name": "Relatlimab + nivolumab", "url": "https://onco.cc/drugs/relatlimab-nivolumab/" }, { "id": "melanoma", "kind": "cancer", "name": "Melanoma", "url": "https://onco.cc/cancers/melanoma/" }, { "id": "advanced-melanoma", "kind": "cancer", "name": "Advanced melanoma", "url": "https://onco.cc/cancers/advanced-melanoma/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT04810078?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT04810078?tab=results", "title": "A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advance: Phase 3 result", "content_text": "Adjusted Geometric Mean Serum Concentration of Nivolumab Over 28 Days (Cavgd28) on Original Scale: Nivolumab SC 77.373 μg/ml versus Nivolumab IV 36.875 μg/ml versus Nivo SC Process C 75.504 μg/ml versus Nivo SC Process D 75.596 μg/ml.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct04810078", "kind": "trial", "name": "A Study of Subcutaneous Nivolumab Versus Intravenous Nivolumab in Participants With Previously Treated Clear Cell Renal Cell Carcinoma That is Advance", "url": "https://onco.cc/trials/nct04810078/" }, { "id": "nivolumab", "kind": "drug", "name": "Nivolumab", "url": "https://onco.cc/drugs/nivolumab/" }, { "id": "rcc", "kind": "cancer", "name": "Renal cell carcinoma", "url": "https://onco.cc/cancers/rcc/" }, { "id": "clear-cell-rcc", "kind": "cancer", "name": "Clear cell renal cell carcinoma", "url": "https://onco.cc/cancers/clear-cell-rcc/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT04765059?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT04765059?tab=results", "title": "A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer: Phase 3 result", "content_text": "Progression Free Survival (PFS): Treatment Arm A: Osimertinib (AZD9291), Pemetrexed, Cisplatin or Carboplatin 8.4 months versus Treatment Arm B: Placebo for Osimertinib (AZD9291), Pemetrexed, Cisplatin or Carboplatin 4.4 months, hazard ratio 0.43.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct04765059", "kind": "trial", "name": "A Study to Evaluate Chemotherapy Plus Osimertinib Against Chemotherapy Plus Placebo in Patients With Non-small Cell Lung Cancer", "url": "https://onco.cc/trials/nct04765059/" }, { "id": "osimertinib", "kind": "drug", "name": "Osimertinib", "url": "https://onco.cc/drugs/osimertinib/" }, { "id": "nsclc", "kind": "cancer", "name": "Non-small-cell lung cancer", "url": "https://onco.cc/cancers/nsclc/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT05456191?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT05456191?tab=results", "title": "A Study to Investigate Tolerability and Efficacy of Asciminib: Phase 3 result", "content_text": "Time to Discontinuation of Study Treatment Due to Adverse Event (TTDAE) (From Interim Analysis): Asciminib 16 participants versus Nilotinib 34 participants, hazard ratio 0.45.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct05456191", "kind": "trial", "name": "A Study to Investigate Tolerability and Efficacy of Asciminib", "url": "https://onco.cc/trials/nct05456191/" }, { "id": "asciminib", "kind": "drug", "name": "Asciminib", "url": "https://onco.cc/drugs/asciminib/" }, { "id": "nilotinib", "kind": "drug", "name": "Nilotinib", "url": "https://onco.cc/drugs/nilotinib/" }, { "id": "cml", "kind": "cancer", "name": "Chronic myeloid leukaemia", "url": "https://onco.cc/cancers/cml/" }, { "id": "cml-chronic-phase", "kind": "cancer", "name": "Chronic myeloid leukaemia, chronic phase", "url": "https://onco.cc/cancers/cml-chronic-phase/" } ] } }, { "id": "https://doi.org/10.1038/s41591-026-04428-0#onco-edge-result", "url": "https://doi.org/10.1038/s41591-026-04428-0", "title": "ALTAIR: Phase 3 result", "content_text": "Median disease-free survival 9.30 against 5.55 months (hazard ratio 0.79, p=0.107): primary endpoint not met.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "DOI", "records": [ { "id": "altair", "kind": "trial", "name": "ALTAIR", "url": "https://onco.cc/trials/altair/" }, { "id": "trifluridine-tipiracil", "kind": "drug", "name": "Trifluridine/tipiracil", "url": "https://onco.cc/drugs/trifluridine-tipiracil/" }, { "id": "signatera", "kind": "drug", "name": "Signatera", "url": "https://onco.cc/drugs/signatera/" }, { "id": "colorectal", "kind": "cancer", "name": "Colorectal cancer", "url": "https://onco.cc/cancers/colorectal/" } ] } }, { "id": "https://clinicaltrials.gov/study/NCT04717414?tab=results#onco-edge-result", "url": "https://clinicaltrials.gov/study/NCT04717414?tab=results", "title": "An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomi: Phase 3 result", "content_text": "Red Blood Cell-transfusion Independence (RBC-TI) ≥ 12 Weeks (RBC-TI 12): Treatment 23.08 % versus Control 13.33 %.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "ClinicalTrials.gov", "records": [ { "id": "nct04717414", "kind": "trial", "name": "An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Subjects With Myeloproliferative Neoplasm-Associated Myelofibrosis on Concomi", "url": "https://onco.cc/trials/nct04717414/" }, { "id": "luspatercept", "kind": "drug", "name": "Luspatercept", "url": "https://onco.cc/drugs/luspatercept/" }, { "id": "myeloproliferative-neoplasms", "kind": "cancer", "name": "Myeloproliferative neoplasms", "url": "https://onco.cc/cancers/myeloproliferative-neoplasms/" }, { "id": "primary-myelofibrosis", "kind": "cancer", "name": "Primary myelofibrosis", "url": "https://onco.cc/cancers/primary-myelofibrosis/" } ] } }, { "id": "https://www.onclive.com/view/iza-bren-yields-pfs-and-os-benefits-vs-chemo-in-previously-treated-advanced-tnbc#onco-edge-result", "url": "https://www.onclive.com/view/iza-bren-yields-pfs-and-os-benefits-vs-chemo-in-previously-treated-advanced-tnbc", "title": "BL-B01D1-307: Phase 3 result", "content_text": "PFS and OS significantly improved at interim analysis (numbers presented ASCO 2026).", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "onclive.com", "records": [ { "id": "bl-b01d1-307", "kind": 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including OS met (July 2026); numbers pending.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "cancernetwork.com", "records": [ { "id": "clarity-gastric01", "kind": "trial", "name": "CLARITY-Gastric 01", "url": "https://onco.cc/trials/clarity-gastric01/" }, { "id": "cmg901", "kind": "drug", "name": "Sonesitatug vedotin", "url": "https://onco.cc/drugs/cmg901/" }, { "id": "ramucirumab", "kind": "drug", "name": "Ramucirumab", "url": "https://onco.cc/drugs/ramucirumab/" }, { "id": "gastric", "kind": "cancer", "name": "Gastric & gastro-oesophageal junction cancer", "url": "https://onco.cc/cancers/gastric/" }, { "id": "cldn18-2", "kind": "target", "name": "Claudin 18.2", "url": "https://onco.cc/targets/cldn18-2/" } ] } }, { "id": "https://www.amgen.com/newsroom/press-releases/2026/09/imdelltra-in-combination-with-imfinzi-demonstrated-landmark-improvement-in-overall-survival-in-first-line-extensive-stage-small-cell-lung-cancer#onco-edge-result", "url": "https://www.amgen.com/newsroom/press-releases/2026/09/imdelltra-in-combination-with-imfinzi-demonstrated-landmark-improvement-in-overall-survival-in-first-line-extensive-stage-small-cell-lung-cancer", "title": "DeLLphi-305: Phase 3 result", "content_text": "Met the primary overall survival endpoint at the pre-specified interim analysis (Amgen, 8 September 2026); progression-free survival and response rate also improved; figures not yet disclosed.", "date_published": "2026-01-01T00:00:00Z", "tags": [ "result" ], "_onco": { "kind": "result", "date": "2026", "precision": "year", "venue": "amgen.com", "records": [ { "id": "dellphi-305", "kind": "trial", "name": "DeLLphi-305", "url": "https://onco.cc/trials/dellphi-305/" }, { "id": "tarlatamab", "kind": "drug", 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