# OnCo record mced (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/mced/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "mced" ;
  schema:name "Multi-cancer early detection (MCED)"@en ;
  schema:alternateName "Multi-cancer detection (MCD)"@en, "Multi-cancer early detection blood test"@en, "Pan-cancer screening blood test"@en ;
  schema:description "A single blood (or urine) test meant to look for many cancers at once, including ones with no screening today. About 27 such tests are sold or in study worldwide; none has yet been shown in a randomised trial to reduce cancer deaths, and the one randomised result so far did not reduce late-stage diagnoses."@en ;
  schema:url <https://onco.cc/technologies/mced/> ;
  schema:dateModified "2026-10-29"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa2505723>, <https://doi.org/10.1038/s41591-026-04618-w>, <https://prevention.cancer.gov/news-and-events/news/nci-selects-two-assays-vanguard-study-multi-cancer-detection-tests>, <https://doi.org/10.1126/science.abb9601>, <https://doi.org/10.3390/cancers14194818>, <https://doi.org/10.1038/s41591-026-04652-8> ;
  onco:status "phase-3" ;
  onco:tag "precision", "evidence:insufficient" ;
  onco:related <https://onco.cc/roadmaps/ctdna-tests/> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/> ;
  onco:sections <https://onco.cc/fronts/early-detection/>, <https://onco.cc/fronts/diagnostics/> ;
  onco:drugs <https://onco.cc/drugs/galleri/>, <https://onco.cc/drugs/cancerguard/>, <https://onco.cc/drugs/shield-mcd/>, <https://onco.cc/drugs/avantect-mcd/>, <https://onco.cc/drugs/harbinger-resolve/>, <https://onco.cc/drugs/cancerseek/>, <https://onco.cc/drugs/onetest/>, <https://onco.cc/drugs/novelna-protein-test/>, <https://onco.cc/drugs/adela-mced/>, <https://onco.cc/drugs/gagome-mced-test/>, <https://onco.cc/drugs/carcimun-test/>, <https://onco.cc/drugs/dxcover-cancer-liquid-biopsy/>, <https://onco.cc/drugs/pantum-detect/>, <https://onco.cc/drugs/nu-q-cancer/>, <https://onco.cc/drugs/thromboseq/>, <https://onco.cc/drugs/epipangi-dx/>, <https://onco.cc/drugs/overc-mcdbt/>, <https://onco.cc/drugs/panseer/>, <https://onco.cc/drugs/oncoseek/>, <https://onco.cc/drugs/seekincare/>, <https://onco.cc/drugs/spot-mas/>, <https://onco.cc/drugs/trucheck-intelli/>, <https://onco.cc/drugs/anpac-cda/>, <https://onco.cc/drugs/n-nose/>, <https://onco.cc/drugs/cancerfind/>, <https://onco.cc/drugs/ai-cancerch/>, <https://onco.cc/drugs/aminoindex-cancer-screening/>, <https://onco.cc/drugs/shield/> ;
  onco:companies <https://onco.cc/companies/grail/>, <https://onco.cc/companies/exact-sciences/>, <https://onco.cc/companies/guardant-health/>, <https://onco.cc/companies/clearnote-health/>, <https://onco.cc/companies/harbinger-health/>, <https://onco.cc/companies/adela/>, <https://onco.cc/companies/elypta/>, <https://onco.cc/companies/exai-bio/>, <https://onco.cc/companies/numen/>, <https://onco.cc/companies/owlstone-medical/>, <https://onco.cc/companies/volitionrx/>, <https://onco.cc/companies/carrum-health/>, <https://onco.cc/companies/delfi-diagnostics/>, <https://onco.cc/companies/freenome/>, <https://onco.cc/companies/burning-rock/>, <https://onco.cc/companies/singlera/>, <https://onco.cc/companies/seekin/>, <https://onco.cc/companies/gene-solutions/>, <https://onco.cc/companies/datar-cancer-genetics/>, <https://onco.cc/companies/hirotsu-bio-science/>, <https://onco.cc/companies/imbdx/>, <https://onco.cc/companies/gc-genome/>, <https://onco.cc/companies/mirxes/>, <https://onco.cc/companies/novelna/>, <https://onco.cc/companies/dxcover/>, <https://onco.cc/companies/zyagnum/>, <https://onco.cc/companies/2020-biolabs/> ;
  onco:terms <https://onco.cc/terms/ppv/>, <https://onco.cc/terms/stage-shift/>, <https://onco.cc/terms/screening/>, <https://onco.cc/terms/cfdna/> ;
  onco:trials <https://onco.cc/trials/nhs-galleri/>, <https://onco.cc/trials/pathfinder-2/>, <https://onco.cc/trials/vanguard-study/>, <https://onco.cc/trials/pathfinder/>, <https://onco.cc/trials/ccga/>, <https://onco.cc/trials/strive-grail/>, <https://onco.cc/trials/reflection-galleri/>, <https://onco.cc/trials/reach-galleri-medicare/>, <https://onco.cc/trials/galleri-community-research-program/>, <https://onco.cc/trials/galleri-unintentional-weight-loss/>, <https://onco.cc/trials/inform-galleri/>, <https://onco.cc/trials/sentinel-galleri-veterans/>, <https://onco.cc/trials/discover-galleri-symptomatic/>, <https://onco.cc/trials/oc-lead/>, <https://onco.cc/trials/ascend-cancerseek/>, <https://onco.cc/trials/falcon-registry/>, <https://onco.cc/trials/regenerate-pancreatic-genetics-mced/>, <https://onco.cc/trials/alliance-a212102-mced-reference-set/>, <https://onco.cc/trials/mayo-mcd-cohort/>, <https://onco.cc/trials/clearnote-multi-cancer-epigenomics/>, <https://onco.cc/trials/inova-burn-pit-screening/>, <https://onco.cc/trials/inova-firefighter-screening/>, <https://onco.cc/trials/mdacc-mced-decision-aid/>, <https://onco.cc/trials/dartmouth-mced-information-trial/>, <https://onco.cc/trials/predict-overc/>, <https://onco.cc/trials/thunder-overc/>, <https://onco.cc/trials/prevent-overc/>, <https://onco.cc/trials/promise-cams/>, <https://onco.cc/trials/prescient-cams/>, <https://onco.cc/trials/perceive-1/>, <https://onco.cc/trials/perceive-2/>, <https://onco.cc/trials/fusion-singlera/>, <https://onco.cc/trials/inspire-singlera/>, <https://onco.cc/trials/lev87a/>, <https://onco.cc/trials/lev93a/>, <https://onco.cc/trials/vincere-firefighters-mced/>, <https://onco.cc/trials/core-hh/>, <https://onco.cc/trials/procares/>, <https://onco.cc/trials/camperr/>, <https://onco.cc/trials/cadence-mirxes/>, <https://onco.cc/trials/pan-owlstone/>, <https://onco.cc/trials/k-detek/>, <https://onco.cc/trials/k-accelerate/>, <https://onco.cc/trials/profound-mced/>, <https://onco.cc/trials/prosight-mced/>, <https://onco.cc/trials/profuture-mced/>, <https://onco.cc/trials/nqmd-cs/>, <https://onco.cc/trials/jinling-cohort/>, <https://onco.cc/trials/wuhan-pan-cancer-methylation-pcr/>, <https://onco.cc/trials/beijing-metabolomics-multi-cancer/>, <https://onco.cc/trials/decipher-gastro/>, <https://onco.cc/trials/yonsei-mced-wgs/>, <https://onco.cc/trials/yonsei-mced-wgs-2/>, <https://onco.cc/trials/yonsei-multi-cancer-mrd/>, <https://onco.cc/trials/methylscape-co/>, <https://onco.cc/trials/exopert-emerald/>, <https://onco.cc/trials/pantum-detect-max-healthcare/>, <https://onco.cc/trials/pantumpet/>, <https://onco.cc/trials/xijing-cfdna-seven-cancers/>, <https://onco.cc/trials/exai-oncrna-prospective/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-nhs-galleri-primary-nejm-2026/>, <https://onco.cc/key-papers/paper-nhs-galleri-performance-nat-med-2026/>, <https://onco.cc/key-papers/paper-pathfinder-2-nat-med-2026/>, <https://onco.cc/key-papers/paper-nhs-galleri-design-cancers-2022/>, <https://onco.cc/key-papers/paper-pathfinder-lancet-2023/>, <https://onco.cc/key-papers/paper-klein-ccga3-mced-validation-ann-oncol-2021/>, <https://onco.cc/key-papers/paper-liu-ccga2-methylation-ann-oncol-2020/>, <https://onco.cc/key-papers/paper-symplify-lancet-oncol-2023/>, <https://onco.cc/key-papers/paper-detect-a-science-2020/>, <https://onco.cc/key-papers/paper-cohen-cancerseek-multi-analyte-blood-test-science-2018/>, <https://onco.cc/key-papers/paper-cancerguard-mp-classifier-cebp-2026/>, <https://onco.cc/key-papers/paper-cristiano-delfi-fragmentomes-nature-2019/>, <https://onco.cc/key-papers/paper-gao-thunder-ann-oncol-2023/>, <https://onco.cc/key-papers/paper-spot-mas-k-detek-bmc-med-2025/>, <https://onco.cc/key-papers/paper-bao-fragmentomics-nat-med-2025/>, <https://onco.cc/key-papers/paper-bratulic-gagome-pnas-2022/>, <https://onco.cc/key-papers/paper-thromboseq-cancer-cell-2022/>, <https://onco.cc/key-papers/paper-hinestrosa-ev-protein-commun-med-2022/>, <https://onco.cc/key-papers/paper-fahrmann-ca19-9-lead-time-gastroenterology-2021/> ;
  onco:dependsOn <https://onco.cc/technologies/liquid-biopsy/> .