# THUNDER (blinded validation of Burning Rock's methylation test)

Source: https://onco.cc/trials/thunder-overc/  
OnCo record `thunder-overc` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The Chinese validation study behind Burning Rock's OverC multi-cancer blood test, published in Annals of Oncology in 2023.

## Summary

THUNDER (NCT04820868) is an observational study sponsored by Shanghai Zhongshan Hospital with Guangzhou Burning Rock Dx Co., Ltd. It validated the cell-free DNA methylation model for early cancer detection, with blood RNA markers also evaluated.

The registry record, read on 29 October 2026, gives its status as completed, with 2,508 participants enrolled, a start on 23 April 2021 and primary completion on 30 November 2021.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-10-29
- Also known as: THUNDER; The Unintrusive Detection of EaRly-stage Cancers
- Registry id: NCT04820868
- Phase: observational
- Setting: People with cancer and people without cancer in China, in a blinded prospective validation of a cell-free DNA methylation model
- Sponsor: Shanghai Zhongshan Hospital with Guangzhou Burning Rock Dx Co., Ltd.
- Enrolled: 2508

## Sources

- ClinicalTrials.gov NCT04820868: https://clinicaltrials.gov/study/NCT04820868

## Connected records

- fronts: [Early Detection & Screening](https://onco.cc/fronts/early-detection/)
- technologies: [Liquid biopsy (ctDNA)](https://onco.cc/technologies/liquid-biopsy/), [Multi-cancer early detection (MCED)](https://onco.cc/technologies/mced/)
- drugs: [OverC Multi-Cancer Detection Blood Test](https://onco.cc/drugs/overc-mcdbt/)
- companies: [Burning Rock Biotech](https://onco.cc/companies/burning-rock/)
- key papers: [Unintrusive multi-cancer detection by circulating cell-free DNA methylation sequencing (THUNDER): development and independent validation studies](https://onco.cc/key-papers/paper-gao-thunder-ann-oncol-2023/)

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