# PREDICT (Burning Rock pan-cancer early detection project)

Source: https://onco.cc/trials/predict-overc/  
OnCo record `predict-overc` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A Chinese study of about 14,000 people used to develop and validate Burning Rock's methylation blood test for several cancers.

## Summary

PREDICT (NCT04383353) is an observational study sponsored by Guangzhou Burning Rock Dx Co., Ltd. It develops and validates a cell-free DNA methylation model, assessing sensitivity, specificity and tissue-of-origin accuracy. The same study has a second registry entry, NCT04817306, sponsored by Shanghai Zhongshan Hospital with Burning Rock.

The registry record, read on 29 October 2026, gives its status as unknown (the sponsor last updated it on 22 July 2020), with an estimated 14,026 participants, a planned start in 21 July 2020 and primary completion expected in October 2022.

## Fields

- Kind: Trial
- Last checked: 2026-10-29
- Also known as: PREDICT; Pan-canceR Early DetectIon projeCT; NCT04817306
- Registry id: NCT04383353
- Phase: observational
- Setting: People with early-stage cancers or benign disease and people without cancer at Chinese hospitals, in a two-stage development and validation of a cell-free DNA methylation model
- Sponsor: Guangzhou Burning Rock Dx Co., Ltd.
- Enrolled: 14026

## Sources

- ClinicalTrials.gov NCT04383353: https://clinicaltrials.gov/study/NCT04383353
- ClinicalTrials.gov NCT04817306: https://clinicaltrials.gov/study/NCT04817306

## Connected records

- fronts: [Early Detection & Screening](https://onco.cc/fronts/early-detection/)
- technologies: [Liquid biopsy (ctDNA)](https://onco.cc/technologies/liquid-biopsy/), [Multi-cancer early detection (MCED)](https://onco.cc/technologies/mced/)
- drugs: [OverC Multi-Cancer Detection Blood Test](https://onco.cc/drugs/overc-mcdbt/)
- companies: [Burning Rock Biotech](https://onco.cc/companies/burning-rock/)

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