# MabQuest

Source: https://onco.cc/companies/mabquest/  
OnCo record `mabquest` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

MabQuest is a Swiss company developing a new kind of anti-PD-1 antibody, a checkpoint inhibitor that releases a brake on the immune system, which binds PD-1 at a different site from current drugs. It is in an early trial in advanced solid tumours.

## Summary

MabQuest SA (MabQuest Therapeutics) was founded in Lausanne, Switzerland, by Giuseppe Pantaleo and Craig Fenwick of Lausanne University Hospital, according to the company, and develops allosteric anti-PD-1 antibodies intended to work alongside conventional orthosteric anti-PD-1 therapies and other checkpoint inhibitors; it also lists interests in infectious disease and allergy. Its lead candidate is MAQ-001. Its first registered cancer trial, NCT06514651, a phase 1a/1b study of intravenous MAQ-001 alone and in combination immunotherapy, including with ipilimumab, in advanced solid tumours at French sites, was posted on ClinicalTrials.gov in July 2024.

## Fields

- Kind: Company
- Last checked: 2026-10-29
- Also known as: MabQuest SA; MabQuest Therapeutics
- HQ: Lausanne
- Type: biotech
- Website: https://mabquest.co/

## Notes

- Founding year and financing not stated on the pages read. That MAQ-001 is the allosteric anti-PD-1 antibody is inferred from the company's single described programme and the registry record. Read on 29 October 2026.

## Sources

- Official website: https://mabquest.co/
- About MabQuest: https://mabquest.co/about-us
- ClinicalTrials.gov: phase 1a/1b trial of MAQ-001 (NCT06514651): https://clinicaltrials.gov/study/NCT06514651

## Connected records

- fronts: [Immunotherapy](https://onco.cc/fronts/immunotherapy/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Monoclonal antibodies](https://onco.cc/technologies/monoclonal-antibody/)
- targets: [PD-1](https://onco.cc/targets/pd1/)

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JSON: https://onco.cc/api/v1/entities/mabquest.json